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Protein
Submitted name:

RAS guanyl-releasing protein 2

Gene

RASGRP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
RAS guanyl-releasing protein 2Imported
Gene namesi
Name:RASGRP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000068831.18
HGNCiHGNC:9879 RASGRP2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000068831

PTM / Processingi

Proteomic databases

PeptideAtlasiC9JZ82
PRIDEiC9JZ82

Expressioni

Gene expression databases

BgeeiENSG00000068831 Expressed in 208 organ(s), highest expression level in blood
ExpressionAtlasiC9JZ82 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliC9JZ82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 83N-terminal Ras-GEFInterPro annotationAdd BLAST80

Phylogenomic databases

eggNOGiKOG3417 Eukaryota
ENOG410XR96 LUCA
GeneTreeiENSGT00880000137870

Family and domain databases

CDDicd06224 REM, 1 hit
InterProiView protein in InterPro
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
PANTHERiPTHR23113 PTHR23113, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50212 RASGEF_NTER, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

C9JZ82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS
60 70 80
QLAAKLLHIY QQSRKDNSNS LQVKTCHLVR YWI
Length:83
Mass (Da):9,611
Last modified:October 5, 2016 - v8
Checksum:i822D5FBC4A90B1DC
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7LDG7GRP2_HUMAN
RAS guanyl-releasing protein 2
RASGRP2 CDC25L, MCG7
609Annotation score:
E7EM78E7EM78_HUMAN
RAS guanyl-releasing protein 2
RASGRP2
232Annotation score:
E7EWQ7E7EWQ7_HUMAN
RAS guanyl-releasing protein 2
RASGRP2
126Annotation score:
E7EMB4E7EMB4_HUMAN
RAS guanyl-releasing protein 2
RASGRP2
125Annotation score:
A6NJ28A6NJ28_HUMAN
RAS guanyl-releasing protein 2
RASGRP2
148Annotation score:
A6NHE2A6NHE2_HUMAN
RAS guanyl-releasing protein 2
RASGRP2
97Annotation score:
A8MVK8A8MVK8_HUMAN
RAS guanyl-releasing protein 2
RASGRP2
63Annotation score:
A8MTF9A8MTF9_HUMAN
RAS guanyl-releasing protein 2
RASGRP2
66Annotation score:
C9JKH6C9JKH6_HUMAN
RAS guanyl-releasing protein 2
RASGRP2
13Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei83Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001462 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000430645; ENSP00000401314; ENSG00000068831
UCSCiuc058czc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001462 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9JZ82
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiC9JZ82
PRIDEiC9JZ82

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000430645; ENSP00000401314; ENSG00000068831
UCSCiuc058czc.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000068831.18
HGNCiHGNC:9879 RASGRP2
OpenTargetsiENSG00000068831
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3417 Eukaryota
ENOG410XR96 LUCA
GeneTreeiENSGT00880000137870

Gene expression databases

BgeeiENSG00000068831 Expressed in 208 organ(s), highest expression level in blood
ExpressionAtlasiC9JZ82 baseline and differential

Family and domain databases

CDDicd06224 REM, 1 hit
InterProiView protein in InterPro
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
PANTHERiPTHR23113 PTHR23113, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50212 RASGEF_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JZ82_HUMAN
AccessioniPrimary (citable) accession number: C9JZ82
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 5, 2016
Last modified: November 7, 2018
This is version 75 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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