Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spectrin beta chain

Gene

SPTBN4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin cappingUniRule annotation, Actin-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Spectrin beta chainUniRule annotation
Gene namesi
Name:SPTBN4Imported
Synonyms:SPNB4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160460.15
HGNCiHGNC:14896 SPTBN4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160460

PTM / Processingi

Proteomic databases

EPDiC9JY79
PeptideAtlasiC9JY79
PRIDEiC9JY79

Expressioni

Gene expression databases

BgeeiENSG00000160460 Expressed in 178 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiC9JY79 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiC9JY79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 165Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini180 – 285Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini2418 – 2527PHInterPro annotationAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili120 – 140Sequence analysisAdd BLAST21
Coiled coili464 – 498Sequence analysisAdd BLAST35
Coiled coili626 – 646Sequence analysisAdd BLAST21
Coiled coili755 – 775Sequence analysisAdd BLAST21
Coiled coili1125 – 1145Sequence analysisAdd BLAST21
Coiled coili1445 – 1472Sequence analysisAdd BLAST28
Coiled coili1663 – 1690Sequence analysisAdd BLAST28
Coiled coili2016 – 2036Sequence analysisAdd BLAST21
Coiled coili2083 – 2103Sequence analysisAdd BLAST21
Coiled coili2286 – 2306Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the spectrin family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813
HOGENOMiHOG000170092
HOVERGENiHBG057912
OrthoDBiEOG091G003V

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 14 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 16 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

C9JY79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQVPGEVDN MEGLPAPNNN PAARWESPDR GWEREQPAAS TAAASLFECS
60 70 80 90 100
RIKALADERE AVQKKTFTKW VNSHLARVGC HIGDLYVDLR DGFVLTRLLE
110 120 130 140 150
VLSGEQLPRP TRGRMRIHSL ENVDKALQFL KEQRVHLENV GSHDIVDGNH
160 170 180 190 200
RLTLGLVWTI ILRFQIQVIK IETEDNRETR SAKDALLLWC QMKTAGYPEV
210 220 230 240 250
NIQNFTTSWR DGLAFNALIH RHRPDLVDFS KLTKSNANYN LQRAFRTAEQ
260 270 280 290 300
HLGLARLLDP EDVNMEAPDE KSIITYVVSF YHYFSKMKAL AVEGKRIGKV
310 320 330 340 350
LDQVLEVGKI IERYEELAAE LLAWIHRTVG LISNQKFANS LSGVQQQLQA
360 370 380 390 400
FTAYCTLEKP VKFQEKGNLE VLLFSIQSKL RACNRRLFVP REGCGIWDID
410 420 430 440 450
KAWGELEKAE HEREAALRAE LIRQEKLELL AQRFDHKVAM RESWLNENQR
460 470 480 490 500
LVSQDNFGYE LPAVEAAMKK HEAIEADIAA YEERVQGVAE LAQALAAEGY
510 520 530 540 550
YDIRRVAAQR DSVLRQWALL TGLVGARRTR LEQNLALQKV FQEMVYMVDW
560 570 580 590 600
MEEMQAQLLS RECGQHLVEA DDLLQKHGLL EGDIAAQSER VEALNAAALR
610 620 630 640 650
FSQLQGYQPC DPQVICNRVN HVHGCLAELQ EQAARRRAEL EASRSLWALL
660 670 680 690 700
QELEEAESWA RDKERLLEAA GGGGAAGAAG AAGTAGGAHD LSSTARLLAQ
710 720 730 740 750
HKILQGELGG RRALLQQALR CGEELVAAGG AVGPGADTVH LVGLAERAAS
760 770 780 790 800
ARRRWQRLEE AAARRERRLQ EARALHQFGA DLDGLLDWLR DAYRLAAAGD
810 820 830 840 850
FGHDEASSRR LARQHRALTG EVEAHRGPVS GLRRQLATLG GASGAGPLVV
860 870 880 890 900
ALQVRVVEAE QLFAEVTEVA ALRRQWLRDA LAVYRMFGEV HACELWIGEK
910 920 930 940 950
EQWLLSMRVP DSLDDVEVVQ HRFESLDQEM NSLMGRVLDV NHTVQELVEG
960 970 980 990 1000
GHPSSDEVRS CQDHLNSRWN RIVELVEQRK EEMSAVLLVE NHVLEVAEVR
1010 1020 1030 1040 1050
AQVREKRRAV ESAPRAGGAL QWRLSGLEAA LQALEPRQAA LLEEAALLAE
1060 1070 1080 1090 1100
RFPAQAARLH QGAEELGAEW GALASAAQAC GEAVAAAGRL QRFLHDLDAF
1110 1120 1130 1140 1150
LDWLVRAQEA AGGSEGPLPN SLEEADALLA RHAALKEEVD QREEDYARIV
1160 1170 1180 1190 1200
AASEALLAAD GAELGPGLAL DEWLPHLELG WHKLLGLWEA RREALVQAHI
1210 1220 1230 1240 1250
YQLFLRDLRQ ALVVLRNQEM ALSGAELPGT VESVEEALKQ HRDFLTTMEL
1260 1270 1280 1290 1300
SQQKMQVAVQ AAEGLLRQGN IYGEQAQEAV TRLLEKNQEN QLRAQQWMQK
1310 1320 1330 1340 1350
LHDQLELQHF LRDCHELDGW IHEKMLMARD GTREDNHKLH KRWLRHQAFM
1360 1370 1380 1390 1400
AELAQNKEWL EKIEREGQQL MQEKPELAAS VRKKLGEIRQ CWAELESTTQ
1410 1420 1430 1440 1450
AKARQLFEAS KADQLVQSFA ELDKKLLHME SQLQDVDPGG DLATVNSQLK
1460 1470 1480 1490 1500
KLQSMESQVE EWYREVGELQ AQTAALPLEP ASKELVGERQ NAVGERLVRL
1510 1520 1530 1540 1550
LEPLQERRRL LLASKELHQV AHDWTTSWAW VQERLPLAMQ TERGNGLQAV
1560 1570 1580 1590 1600
QQHIKKNQGL RREIQAHGPR LEEVLERAGA LASLRSPEAE AVRRGLEQLQ
1610 1620 1630 1640 1650
SAWAGLREAA ERRQQVLDAA FQVEQYYFDV AEVEAWLGEQ ELLMMSEDKG
1660 1670 1680 1690 1700
KDEQSTLQLL KKHLQLEQGV ENYEESIAQL SRQCRALLEM GHPDSEQISR
1710 1720 1730 1740 1750
RQSQVDRLYV ALKELGEERR VALEQQYWLY QLSRQVSELE HWIAEKEVVA
1760 1770 1780 1790 1800
GSPELGQDFE HVSVLQEKFS EFASETGMAG RERLAAVNQM VDELIECGHT
1810 1820 1830 1840 1850
AAATMAEWKD GLNEAWAELL ELMGTRAQLL AASRELHKFF SDARELQGQI
1860 1870 1880 1890 1900
EEKRRRLPRL TTPPEPRPSA SSMQRTLRAF EHDLQLLVSQ VRQLQEGAAQ
1910 1920 1930 1940 1950
LRTVYAGEHA EAIASREQEV LQGWKELLSA CEDARLHVSS TADALRFHSQ
1960 1970 1980 1990 2000
VRDLLSWMDG IASQIGAADK PRDVSSVEVL MNYHQGLKTE LEARVPELTT
2010 2020 2030 2040 2050
CQELGRSLLL NKSAMADEIQ AQLDKLGTRK EEVSEKWDRH WEWLQQMLEV
2060 2070 2080 2090 2100
HQFAQEAVVA DAWLTAQEPL LQSRELGSSV DEVEQLIRRH EAFRKAAAAW
2110 2120 2130 2140 2150
EERFSSLRRL TTIEKIKAEQ SKQPPTPLLG RKFFGDPTEL AAKAAPLLRP
2160 2170 2180 2190 2200
GGYERGLEPL ARRASDTLSA EVRTRVGYVR QELKPERLQP RIDRLPEIPG
2210 2220 2230 2240 2250
RVEPAALPAA PEDAAETPAT PAAAEQVRPR PERQESADRA EELPRRRRPE
2260 2270 2280 2290 2300
RQESVDQSEE AARRRRPERQ ESAEHEAAHS LTLGRYEQME RRRERRERRL
2310 2320 2330 2340 2350
ERQESSEQEM PIRGDLVKGK ATLADIVEQL QEKEAGPGLP AGPSLPQPRE
2360 2370 2380 2390 2400
LPPGRLPNGL ELPERTPRPD RPRARDRPKP RRRPRPREGG EGGGSRRSRS
2410 2420 2430 2440 2450
APAQGGSAPA PPPPPTHTVQ HEGFLLRKRE LDANRKSSNR SWVSLYCVLS
2460 2470 2480 2490 2500
KGELGFYKDS KGPASGSTHG GEPLLSLHKA TSEVASDYKK KKHVFKLQTQ
2510 2520 2530 2540 2550
DGSEFLLQAK DEEEMNGWLE AVASSVAEHA EIARWGQTLP TTSSTDEGNP
2560
KREGGDRRAS GRRK
Length:2,564
Mass (Da):289,061
Last modified:October 29, 2014 - v2
Checksum:iCB1CACB2FF977776
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9H254SPTN4_HUMAN
Spectrin beta chain, non-erythrocyt...
SPTBN4 KIAA1642, SPTBN3
2,564Annotation score:
M0QZQ3M0QZQ3_HUMAN
Spectrin beta chain
SPTBN4
2,002Annotation score:
M0R1V6M0R1V6_HUMAN
Spectrin beta chain, non-erythrocyt...
SPTBN4
701Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020929 Genomic DNA No translation available.
KF511269 Genomic DNA No translation available.
AF324063 mRNA Translation: AAQ14860.1
UniGeneiHs.32706

Genome annotation databases

EnsembliENST00000338932; ENSP00000340345; ENSG00000160460
ENST00000392025; ENSP00000375879; ENSG00000160460
UCSCiuc060ysp.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020929 Genomic DNA No translation available.
KF511269 Genomic DNA No translation available.
AF324063 mRNA Translation: AAQ14860.1
UniGeneiHs.32706

3D structure databases

SMRiC9JY79
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiC9JY79
PeptideAtlasiC9JY79
PRIDEiC9JY79

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338932; ENSP00000340345; ENSG00000160460
ENST00000392025; ENSP00000375879; ENSG00000160460
UCSCiuc060ysp.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000160460.15
HGNCiHGNC:14896 SPTBN4
OpenTargetsiENSG00000160460
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813
HOGENOMiHOG000170092
HOVERGENiHBG057912
OrthoDBiEOG091G003V

Gene expression databases

BgeeiENSG00000160460 Expressed in 178 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiC9JY79 baseline and differential

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 14 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 16 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JY79_HUMAN
AccessioniPrimary (citable) accession number: C9JY79
Secondary accession number(s): E9PDB1, Q71S07
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again