Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

DHTKD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialImported
Gene namesi
Name:DHTKD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000181192.11
HGNCiHGNC:23537 DHTKD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181192

PTM / Processingi

Proteomic databases

EPDiC9JWN1
PeptideAtlasiC9JWN1
PRIDEiC9JWN1

Expressioni

Gene expression databases

BgeeiENSG00000181192 Expressed in 219 organ(s), highest expression level in liver
ExpressionAtlasiC9JWN1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9JWN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 307E1_dhInterPro annotationAdd BLAST111

Phylogenomic databases

eggNOGiKOG0450 Eukaryota
COG0567 LUCA
GeneTreeiENSGT00530000063092

Family and domain databases

InterProiView protein in InterPro
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR029061 THDP-binding
PANTHERiPTHR23152 PTHR23152, 2 hits
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

C9JWN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASATAAAAR RGLGRALPLF WRGYQTERGV YGYRPRKPES REPQGALERP
60 70 80 90 100
PVDHGLARLV TVYCEHGHKA AKINPLFTGQ ALLENVPEIQ ALVQTLQGPF
110 120 130 140 150
HTAGLLNMGK EEASLEEVLV YLNQIYCGQI SIETSQLQSQ DEKDWFAKRF
160 170 180 190 200
EELQKETFTT EERKHLSKLM LESQLMFRKM RGLSEFPENF SATGDVLSHL
210 220 230 240 250
TSSVDLYFGA HHPLHVTMLP NPSHLEAVNP VAVGKTRGRQ QSRQDGDYSP
260 270 280 290 300
DNSAQPGDRV ICLQVHGDAS FCGQGIVPET FTLSNLPHFR IGGSVHLIVN

NQLGYTT
Length:307
Mass (Da):34,177
Last modified:October 5, 2016 - v8
Checksum:iA32046278B66D6D3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96HY7DHTK1_HUMAN
Probable 2-oxoglutarate dehydrogena...
DHTKD1 KIAA1630
919Annotation score:
H7C149H7C149_HUMAN
Probable 2-oxoglutarate dehydrogena...
DHTKD1
214Annotation score:
H7C1J3H7C1J3_HUMAN
Probable 2-oxoglutarate dehydrogena...
DHTKD1
160Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei307Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073160 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000437298; ENSP00000388163; ENSG00000181192
UCSCiuc057rrs.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073160 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9JWN1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiC9JWN1
PeptideAtlasiC9JWN1
PRIDEiC9JWN1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437298; ENSP00000388163; ENSG00000181192
UCSCiuc057rrs.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000181192.11
HGNCiHGNC:23537 DHTKD1
OpenTargetsiENSG00000181192
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0450 Eukaryota
COG0567 LUCA
GeneTreeiENSGT00530000063092

Miscellaneous databases

ChiTaRSiDHTKD1 human

Gene expression databases

BgeeiENSG00000181192 Expressed in 219 organ(s), highest expression level in liver
ExpressionAtlasiC9JWN1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR029061 THDP-binding
PANTHERiPTHR23152 PTHR23152, 2 hits
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JWN1_HUMAN
AccessioniPrimary (citable) accession number: C9JWN1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 60 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again