UniProtKB - C9JVS8 (C9JVS8_HUMAN)
Protein
E3 ubiquitin-protein ligase RNF182
Gene
RNF182
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase RNF182ARBA annotation (EC:2.3.2.27ARBA annotation)Alternative name(s): RING finger protein 182ARBA annotation RING-type E3 ubiquitin transferase RNF182ARBA annotation |
Gene namesi | Name:RNF182Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28522, RNF182 |
VEuPathDBi | HostDB:ENSG00000180537.12 |
Subcellular locationi
Other locations
- Cytoplasm ARBA annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000180537, Expressed in neocortex and 155 other tissues |
ExpressionAtlasi | C9JVS8, baseline and differential |
Interactioni
Subunit structurei
Interacts with ATP6V0C.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 68 | RING-typeInterPro annotationAdd BLAST | 49 |
Keywords - Domaini
Transmembrane, Transmembrane helixARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00730000111020 |
HOGENOMi | CLU_138894_0_0_1 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR042285, RNF182 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR46675, PTHR46675, 1 hit |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
C9JVS8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASQPPEDTA ESQASDELEC KICYNRYNLK QRKPKVLECC HRVCAKCLYK
60 70 80 90 100
IIDFGDSPQG VIVCPFCRFE TCLPDDEVSS LPDDNNILVN LTCGGKGKKC
110 120 130 140 150
LPENPTELLL TPKRLASLVS PSHTSSNCLV ITIMEVQRES SPSLSSTPVV
160
EFYRPASFDS VT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8N6D2 | RN182_HUMAN | E3 ubiquitin-protein ligase RNF182 | RNF182 | 247 | Annotation score: | ||
C9IZ30 | C9IZ30_HUMAN | E3 ubiquitin-protein ligase RNF182 | RNF182 | 82 | Annotation score: | ||
C9JAK6 | C9JAK6_HUMAN | RING-type E3 ubiquitin transferase | RNF182 | 51 | Annotation score: | ||
C9JAJ3 | C9JAJ3_HUMAN | E3 ubiquitin-protein ligase RNF182 | RNF182 | 13 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 162 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL138718 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000420478; ENSP00000419329; ENSG00000180537 |
UCSCi | uc063lyz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL138718 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | C9JVS8 |
ProteomicsDBi | 11899 |
Protocols and materials databases
Antibodypediai | 1547, 128 antibodies |
Genome annotation databases
Ensembli | ENST00000420478; ENSP00000419329; ENSG00000180537 |
UCSCi | uc063lyz.1, human |
Organism-specific databases
HGNCi | HGNC:28522, RNF182 |
OpenTargetsi | ENSG00000180537 |
VEuPathDBi | HostDB:ENSG00000180537.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00730000111020 |
HOGENOMi | CLU_138894_0_0_1 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Miscellaneous databases
ChiTaRSi | RNF182, human |
Gene expression databases
Bgeei | ENSG00000180537, Expressed in neocortex and 155 other tissues |
ExpressionAtlasi | C9JVS8, baseline and differential |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR042285, RNF182 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR46675, PTHR46675, 1 hit |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C9JVS8_HUMAN | |
Accessioni | C9JVS8Primary (citable) accession number: C9JVS8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |