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Protein
Submitted name:

EGF-containing fibulin-like extracellular matrix protein 1

Gene

EFEMP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 1Imported
Gene namesi
Name:EFEMP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115380.19
HGNCiHGNC:3218 EFEMP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115380

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500841294618 – 61Sequence analysisAdd BLAST44

Proteomic databases

PeptideAtlasiC9JUM4
PRIDEiC9JUM4

Expressioni

Gene expression databases

BgeeiENSG00000115380 Expressed in 226 organ(s), highest expression level in thoracic aorta
ExpressionAtlasiC9JUM4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9JUM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR77 Eukaryota
ENOG410YCRW LUCA
GeneTreeiENSGT00760000118806

Family and domain databases

InterProiView protein in InterPro
IPR032973 EFEMP1
IPR037287 Fibulin_3/4/5
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF2 PTHR44074:SF2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

C9JUM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKALFLTML TLALVKSQDT EETITYTQCT DGYEWDPVRQ QCKDIDECDI
60
VPDACKGGMK C
Length:61
Mass (Da):6,908
Last modified:October 5, 2016 - v8
Checksum:i8B28AB75D9D01874
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q12805FBLN3_HUMAN
EGF-containing fibulin-like extrace...
EFEMP1 FBLN3, FBNL
493Annotation score:
Q580Q6Q580Q6_HUMAN
EGF-containing fibulin-like extrace...
EFEMP1
172Annotation score:
C9JQX7C9JQX7_HUMAN
EGF-containing fibulin-like extrace...
EFEMP1
87Annotation score:
C9JPZ9C9JPZ9_HUMAN
EGF-containing fibulin-like extrace...
EFEMP1
119Annotation score:
C9J4J8C9J4J8_HUMAN
EGF-containing fibulin-like extrace...
EFEMP1
106Annotation score:
A0A0U1RQV3A0A0U1RQV3_HUMAN
EGF-containing fibulin-like extrace...
EFEMP1
280Annotation score:
C9J8S9C9J8S9_HUMAN
EGF-containing fibulin-like extrace...
EFEMP1
51Annotation score:
A0A0U1RRL0A0A0U1RRL0_HUMAN
EGF-containing fibulin-like extrace...
EFEMP1
46Annotation score:
C9J4H7C9J4H7_HUMAN
EGF-containing fibulin-like extrace...
EFEMP1
27Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei61Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010895 Genomic DNA No translation available.
AC096549 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000452337; ENSP00000399480; ENSG00000115380
UCSCiuc061jiy.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010895 Genomic DNA No translation available.
AC096549 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9JUM4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiC9JUM4
PRIDEiC9JUM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452337; ENSP00000399480; ENSG00000115380
UCSCiuc061jiy.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000115380.19
HGNCiHGNC:3218 EFEMP1
OpenTargetsiENSG00000115380
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR77 Eukaryota
ENOG410YCRW LUCA
GeneTreeiENSGT00760000118806

Miscellaneous databases

ChiTaRSiEFEMP1 human

Gene expression databases

BgeeiENSG00000115380 Expressed in 226 organ(s), highest expression level in thoracic aorta
ExpressionAtlasiC9JUM4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR032973 EFEMP1
IPR037287 Fibulin_3/4/5
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF2 PTHR44074:SF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JUM4_HUMAN
AccessioniPrimary (citable) accession number: C9JUM4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 59 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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