UniProtKB - C9JUK9 (C9JUK9_HUMAN)
Protein
Mitogen-activated protein kinase
Gene
MAPK7
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.11.24ARBA annotation
- ATP + L-threonyl-[protein] = ADP + H+ + O-phospho-L-threonyl-[protein]UniRule annotationARBA annotationEC:2.7.11.24UniRule annotationARBA annotation
Cofactori
Mg2+UniRule annotation
Activity regulationi
Activated by threonine and tyrosine phosphorylation.UniRule annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- MAP kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | C9JUK9 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinaseUniRule annotationARBA annotation (EC:2.7.11.24UniRule annotationARBA annotation) |
Gene namesi | Name:MAPK7Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166484.19 |
HGNCi | HGNC:6880, MAPK7 |
PTM / Processingi
Proteomic databases
MaxQBi | C9JUK9 |
PeptideAtlasi | C9JUK9 |
PRIDEi | C9JUK9 |
ProteomicsDBi | 11744 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166484, Expressed in subventricular zone (inner) (primate) and 174 other tissues |
ExpressionAtlasi | C9JUK9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 241 | Protein kinaseInterPro annotationAdd BLAST | 187 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000160215 |
HOGENOMi | CLU_000288_181_1_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
C9JUK9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEPLKEEDG EDGSAEPPGP VKAEPAHTAA SVAAKNLALL KARSFDVTFD
60 70 80 90 100
VGDEYEIIET IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL
110 120 130 140 150
RELKILKHFK HDNIIAIKDI LRPTVPYGEF KSVYVVLDLM ESDLHQIIHS
160 170 180 190 200
SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH RDLKPSNLLV NENCELKIGD
210 220 230 240
FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT Q
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13164 | MK07_HUMAN | Mitogen-activated protein kinase 7 | MAPK7 BMK1, ERK5, PRKM7 | 816 | Annotation score: | ||
J3KT61 | J3KT61_HUMAN | Mitogen-activated protein kinase 7 | MAPK7 | 157 | Annotation score: | ||
S4R3I1 | S4R3I1_HUMAN | Mitogen-activated protein kinase 7 | MAPK7 | 144 | Annotation score: | ||
J3KT50 | J3KT50_HUMAN | Mitogen-activated protein kinase 7 | MAPK7 | 80 | Annotation score: | ||
I3L0J8 | I3L0J8_HUMAN | Mitogen-activated protein kinase 7 | MAPK7 | 195 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 241 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124066 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000443215; ENSP00000412902; ENSG00000166484 |
UCSCi | uc060ckp.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124066 Genomic DNA No translation available. |
3D structure databases
SMRi | C9JUK9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | C9JUK9 |
PeptideAtlasi | C9JUK9 |
PRIDEi | C9JUK9 |
ProteomicsDBi | 11744 |
Protocols and materials databases
Antibodypediai | 4345, 618 antibodies |
Genome annotation databases
Ensembli | ENST00000443215; ENSP00000412902; ENSG00000166484 |
UCSCi | uc060ckp.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166484.19 |
HGNCi | HGNC:6880, MAPK7 |
OpenTargetsi | ENSG00000166484 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160215 |
HOGENOMi | CLU_000288_181_1_1 |
Enzyme and pathway databases
SignaLinki | C9JUK9 |
Miscellaneous databases
ChiTaRSi | MAPK7, human |
Gene expression databases
Bgeei | ENSG00000166484, Expressed in subventricular zone (inner) (primate) and 174 other tissues |
ExpressionAtlasi | C9JUK9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C9JUK9_HUMAN | |
Accessioni | C9JUK9Primary (citable) accession number: C9JUK9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | August 12, 2020 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |