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Protein

Interleukin-1

Gene

IL36RN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1UniRule annotation
Gene namesi
Name:IL36RNImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136695.14
HGNCiHGNC:15561 IL36RN

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136695

PTM / Processingi

Proteomic databases

PRIDEiC9JTH1

Expressioni

Gene expression databases

BgeeiENSG00000136695 Expressed in 105 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiC9JTH1 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliC9JTH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IZIW Eukaryota
ENOG41116AA LUCA
GeneTreeiENSGT00900000141028
HOGENOMiHOG000231506

Family and domain databases

InterProiView protein in InterPro
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR027171 IL-36RA
IPR008996 IL1/FGF
PANTHERiPTHR45145 PTHR45145, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

C9JTH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL
60 70 80 90 100
DASLSPVILG VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF
110
YRRDMGLTSS FESAAYP
Length:117
Mass (Da):12,623
Last modified:November 3, 2009 - v1
Checksum:i0BF67F8440C8F433
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UBH0I36RA_HUMAN
Interleukin-36 receptor antagonist ...
IL36RN FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3 IL36RN FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, UNQ1896/PRO4342
155Annotation score:
U3KPW9U3KPW9_HUMAN
Interleukin-36 receptor antagonist ...
IL36RN
52Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei117Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016724 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000437409; ENSP00000409262; ENSG00000136695
UCSCiuc061nbp.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016724 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9JTH1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiC9JTH1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437409; ENSP00000409262; ENSG00000136695
UCSCiuc061nbp.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000136695.14
HGNCiHGNC:15561 IL36RN
OpenTargetsiENSG00000136695
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZIW Eukaryota
ENOG41116AA LUCA
GeneTreeiENSGT00900000141028
HOGENOMiHOG000231506

Gene expression databases

BgeeiENSG00000136695 Expressed in 105 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiC9JTH1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR027171 IL-36RA
IPR008996 IL1/FGF
PANTHERiPTHR45145 PTHR45145, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JTH1_HUMAN
AccessioniPrimary (citable) accession number: C9JTH1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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