UniProtKB - C9JQI7 (TM232_HUMAN)
Protein
Transmembrane protein 232
Gene
TMEM232
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 232 |
Gene namesi | Name:TMEM232 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:37270, TMEM232 |
neXtProti | NX_C9JQI7 |
VEuPathDBi | HostDB:ENSG00000186952.14 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 168 – 188 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 353 – 373 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 642987 |
OpenTargetsi | ENSG00000186952 |
PharmGKBi | PA165660571 |
Miscellaneous databases
Pharosi | C9JQI7, Tdark |
Genetic variation databases
BioMutai | TMEM232 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395035 | 1 – 657 | Transmembrane protein 232Add BLAST | 657 |
Proteomic databases
MassIVEi | C9JQI7 |
PaxDbi | C9JQI7 |
PeptideAtlasi | C9JQI7 |
PRIDEi | C9JQI7 |
ProteomicsDBi | 11246 [C9JQI7-1] 11247 [C9JQI7-2] |
PTM databases
iPTMneti | C9JQI7 |
PhosphoSitePlusi | C9JQI7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000186952, Expressed in testis and 136 other tissues |
ExpressionAtlasi | C9JQI7, baseline and differential |
Genevisiblei | C9JQI7, HS |
Organism-specific databases
HPAi | ENSG00000186952, Tissue enhanced (fallopian tube, pituitary gland, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 568408, 2 interactors |
IntActi | C9JQI7, 2 interactors |
STRINGi | 9606.ENSP00000401477 |
Miscellaneous databases
RNActi | C9JQI7, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVVE, Eukaryota |
GeneTreei | ENSGT00390000014003 |
HOGENOMi | CLU_015366_1_0_1 |
InParanoidi | C9JQI7 |
OMAi | QEVMKKR |
OrthoDBi | 679293at2759 |
PhylomeDBi | C9JQI7 |
TreeFami | TF336968 |
Family and domain databases
InterProi | View protein in InterPro IPR031747, TMEM232 |
PANTHERi | PTHR28651, PTHR28651, 1 hit |
Pfami | View protein in Pfam PF15877, TMEM232, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: C9JQI7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNMPVNKSPM INTCGGISSP YHEELWKLNF QHLSGERGHK SRPTFSITKE
60 70 80 90 100
FILRFNQTQN SKEKEELLEL ARKIILRCKR KLGLKTLGSG RHVHLPAAWT
110 120 130 140 150
EVIYLAQCKG EIQDESLNML YASLDHASFD YDHLPALFFV AESVLYRLCC
160 170 180 190 200
DASLKTYLYS VEIKLAKIGY LVFLRLFIFF LHGHLESFKQ HLLRLQPYLY
210 220 230 240 250
ALSFSGASYH KYPNIFSNVQ FILKASEIIG KRELRSESIF RPVEDKKRYE
260 270 280 290 300
NTDSDMGGYE INHLLWHCVA AWSCVQNNSP QLNNVLEHLV FHKTQLQKKC
310 320 330 340 350
WLDSVLALLV LGEAAKLNMA CLKALMDVVR DFVSSIMSVQ NQEESCKVDD
360 370 380 390 400
FSWAWNVVYI YTVILAEICL YAATSDLRKT ALIGFCHCKS SQKNILYLDK
410 420 430 440 450
SVPPELKETS ILSLLEYFSS KMSENCDQVV WTGYYGLVYN LVKISWELQG
460 470 480 490 500
DEEQDGLRNM IWQTLQKTKD YEEDVRIQNA INIAQAELND PTDPFTRYST
510 520 530 540 550
NISSNVGEEV FSKYIGWRIA NTLSKLFFPP IEAHFLPLKK PSIKKDQTKY
560 570 580 590 600
PNKKLESVKK QVLHFTVREH PSVSEIPMFP YPDFFTKADK ELAKIIDHHW
610 620 630 640 650
QEELKIREKE DAICKAQELK DKKLAEKNHF QEVMKKREEK LHKQTKPYEL
PYRKEVI
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6REY3 | D6REY3_HUMAN | Transmembrane protein 232 | TMEM232 | 164 | Annotation score: | ||
D6RF96 | D6RF96_HUMAN | Transmembrane protein 232 | TMEM232 | 119 | Annotation score: | ||
D6RC30 | D6RC30_HUMAN | Transmembrane protein 232 | TMEM232 | 247 | Annotation score: | ||
E5RG73 | E5RG73_HUMAN | Transmembrane protein 232 | TMEM232 | 59 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039352 | 486 – 657 | AELND…RKEVI → GTSFCIRNSHVSISRFLHQG R in isoform 1. CuratedAdd BLAST | 172 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK296542 mRNA Translation: BAG59166.1 AC008650 Genomic DNA No translation available. AC010349 Genomic DNA No translation available. AC012622 Genomic DNA No translation available. AC114290 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49042.1 |
CCDSi | CCDS47253.2 [C9JQI7-1] |
RefSeqi | NP_001034852.3, NM_001039763.3 [C9JQI7-1] XP_006714733.1, XM_006714670.3 [C9JQI7-1] XP_011541854.1, XM_011543552.2 [C9JQI7-1] XP_011541855.1, XM_011543553.2 [C9JQI7-1] XP_011541866.1, XM_011543564.2 [C9JQI7-2] XP_016865193.1, XM_017009704.1 |
Genome annotation databases
Ensembli | ENST00000455884; ENSP00000401477; ENSG00000186952 [C9JQI7-1] |
GeneIDi | 642987 |
KEGGi | hsa:642987 |
UCSCi | uc011cvh.4, human [C9JQI7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK296542 mRNA Translation: BAG59166.1 AC008650 Genomic DNA No translation available. AC010349 Genomic DNA No translation available. AC012622 Genomic DNA No translation available. AC114290 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49042.1 |
CCDSi | CCDS47253.2 [C9JQI7-1] |
RefSeqi | NP_001034852.3, NM_001039763.3 [C9JQI7-1] XP_006714733.1, XM_006714670.3 [C9JQI7-1] XP_011541854.1, XM_011543552.2 [C9JQI7-1] XP_011541855.1, XM_011543553.2 [C9JQI7-1] XP_011541866.1, XM_011543564.2 [C9JQI7-2] XP_016865193.1, XM_017009704.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 568408, 2 interactors |
IntActi | C9JQI7, 2 interactors |
STRINGi | 9606.ENSP00000401477 |
PTM databases
iPTMneti | C9JQI7 |
PhosphoSitePlusi | C9JQI7 |
Genetic variation databases
BioMutai | TMEM232 |
Proteomic databases
MassIVEi | C9JQI7 |
PaxDbi | C9JQI7 |
PeptideAtlasi | C9JQI7 |
PRIDEi | C9JQI7 |
ProteomicsDBi | 11246 [C9JQI7-1] 11247 [C9JQI7-2] |
Protocols and materials databases
Antibodypediai | 57493, 16 antibodies |
Genome annotation databases
Ensembli | ENST00000455884; ENSP00000401477; ENSG00000186952 [C9JQI7-1] |
GeneIDi | 642987 |
KEGGi | hsa:642987 |
UCSCi | uc011cvh.4, human [C9JQI7-1] |
Organism-specific databases
CTDi | 642987 |
DisGeNETi | 642987 |
GeneCardsi | TMEM232 |
HGNCi | HGNC:37270, TMEM232 |
HPAi | ENSG00000186952, Tissue enhanced (fallopian tube, pituitary gland, testis) |
neXtProti | NX_C9JQI7 |
OpenTargetsi | ENSG00000186952 |
PharmGKBi | PA165660571 |
VEuPathDBi | HostDB:ENSG00000186952.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVVE, Eukaryota |
GeneTreei | ENSGT00390000014003 |
HOGENOMi | CLU_015366_1_0_1 |
InParanoidi | C9JQI7 |
OMAi | QEVMKKR |
OrthoDBi | 679293at2759 |
PhylomeDBi | C9JQI7 |
TreeFami | TF336968 |
Enzyme and pathway databases
PathwayCommonsi | C9JQI7 |
Miscellaneous databases
BioGRID-ORCSi | 642987, 3 hits in 871 CRISPR screens |
ChiTaRSi | TMEM232, human |
GenomeRNAii | 642987 |
Pharosi | C9JQI7, Tdark |
PROi | PR:C9JQI7 |
RNActi | C9JQI7, protein |
Gene expression databases
Bgeei | ENSG00000186952, Expressed in testis and 136 other tissues |
ExpressionAtlasi | C9JQI7, baseline and differential |
Genevisiblei | C9JQI7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031747, TMEM232 |
PANTHERi | PTHR28651, PTHR28651, 1 hit |
Pfami | View protein in Pfam PF15877, TMEM232, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM232_HUMAN | |
Accessioni | C9JQI7Primary (citable) accession number: C9JQI7 Secondary accession number(s): B4DKF4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 15, 2010 |
Last sequence update: | June 15, 2010 | |
Last modified: | February 10, 2021 | |
This is version 78 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM