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Entry version 68 (08 May 2019)
Sequence version 2 (15 Jun 2010)
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Protein

Transmembrane protein 232

Gene

TMEM232

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 232
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM232
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:37270 TMEM232

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_C9JQI7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
642987

Open Targets

More...
OpenTargetsi
ENSG00000186952

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165660571

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM232

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003950351 – 657Transmembrane protein 232Add BLAST657

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
C9JQI7

PRoteomics IDEntifications database

More...
PRIDEi
C9JQI7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
11246
11247 [C9JQI7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
C9JQI7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
C9JQI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186952 Expressed in 114 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
C9JQI7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
C9JQI7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049386

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
C9JQI7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000401477

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG5N Eukaryota
ENOG4111R3E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014003

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000054199

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C9JQI7

Identification of Orthologs from Complete Genome Data

More...
OMAi
LNMLYAS

Database of Orthologous Groups

More...
OrthoDBi
679293at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
C9JQI7

TreeFam database of animal gene trees

More...
TreeFami
TF336968

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031747 TMEM232

The PANTHER Classification System

More...
PANTHERi
PTHR28651 PTHR28651, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15877 TMEM232, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: C9JQI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNMPVNKSPM INTCGGISSP YHEELWKLNF QHLSGERGHK SRPTFSITKE
60 70 80 90 100
FILRFNQTQN SKEKEELLEL ARKIILRCKR KLGLKTLGSG RHVHLPAAWT
110 120 130 140 150
EVIYLAQCKG EIQDESLNML YASLDHASFD YDHLPALFFV AESVLYRLCC
160 170 180 190 200
DASLKTYLYS VEIKLAKIGY LVFLRLFIFF LHGHLESFKQ HLLRLQPYLY
210 220 230 240 250
ALSFSGASYH KYPNIFSNVQ FILKASEIIG KRELRSESIF RPVEDKKRYE
260 270 280 290 300
NTDSDMGGYE INHLLWHCVA AWSCVQNNSP QLNNVLEHLV FHKTQLQKKC
310 320 330 340 350
WLDSVLALLV LGEAAKLNMA CLKALMDVVR DFVSSIMSVQ NQEESCKVDD
360 370 380 390 400
FSWAWNVVYI YTVILAEICL YAATSDLRKT ALIGFCHCKS SQKNILYLDK
410 420 430 440 450
SVPPELKETS ILSLLEYFSS KMSENCDQVV WTGYYGLVYN LVKISWELQG
460 470 480 490 500
DEEQDGLRNM IWQTLQKTKD YEEDVRIQNA INIAQAELND PTDPFTRYST
510 520 530 540 550
NISSNVGEEV FSKYIGWRIA NTLSKLFFPP IEAHFLPLKK PSIKKDQTKY
560 570 580 590 600
PNKKLESVKK QVLHFTVREH PSVSEIPMFP YPDFFTKADK ELAKIIDHHW
610 620 630 640 650
QEELKIREKE DAICKAQELK DKKLAEKNHF QEVMKKREEK LHKQTKPYEL

PYRKEVI
Length:657
Mass (Da):76,453
Last modified:June 15, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E6D0910A3422E1E
GO
Isoform 1 (identifier: C9JQI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     486-657: AELNDPTDPF...YELPYRKEVI → GTSFCIRNSHVSISRFLHQGR

Note: No experimental confirmation available.
Show »
Length:506
Mass (Da):58,417
Checksum:i164810E637D8D474
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RC30D6RC30_HUMAN
Transmembrane protein 232
TMEM232
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REY3D6REY3_HUMAN
Transmembrane protein 232
TMEM232
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF96D6RF96_HUMAN
Transmembrane protein 232
TMEM232
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG73E5RG73_HUMAN
Transmembrane protein 232
TMEM232
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039352486 – 657AELND…RKEVI → GTSFCIRNSHVSISRFLHQG R in isoform 1. CuratedAdd BLAST172

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK296542 mRNA Translation: BAG59166.1
AC008650 Genomic DNA No translation available.
AC010349 Genomic DNA No translation available.
AC012622 Genomic DNA No translation available.
AC114290 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49042.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47253.2 [C9JQI7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001034852.3, NM_001039763.3 [C9JQI7-1]
XP_006714733.1, XM_006714670.3 [C9JQI7-1]
XP_011541854.1, XM_011543552.2 [C9JQI7-1]
XP_011541855.1, XM_011543553.2 [C9JQI7-1]
XP_011541866.1, XM_011543564.2 [C9JQI7-2]
XP_016865193.1, XM_017009704.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000455884; ENSP00000401477; ENSG00000186952 [C9JQI7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
642987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:642987

UCSC genome browser

More...
UCSCi
uc011cvh.4 human [C9JQI7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296542 mRNA Translation: BAG59166.1
AC008650 Genomic DNA No translation available.
AC010349 Genomic DNA No translation available.
AC012622 Genomic DNA No translation available.
AC114290 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49042.1
CCDSiCCDS47253.2 [C9JQI7-1]
RefSeqiNP_001034852.3, NM_001039763.3 [C9JQI7-1]
XP_006714733.1, XM_006714670.3 [C9JQI7-1]
XP_011541854.1, XM_011543552.2 [C9JQI7-1]
XP_011541855.1, XM_011543553.2 [C9JQI7-1]
XP_011541866.1, XM_011543564.2 [C9JQI7-2]
XP_016865193.1, XM_017009704.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiC9JQI7, 1 interactor
STRINGi9606.ENSP00000401477

PTM databases

iPTMnetiC9JQI7
PhosphoSitePlusiC9JQI7

Polymorphism and mutation databases

BioMutaiTMEM232

Proteomic databases

PaxDbiC9JQI7
PRIDEiC9JQI7
ProteomicsDBi11246
11247 [C9JQI7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000455884; ENSP00000401477; ENSG00000186952 [C9JQI7-1]
GeneIDi642987
KEGGihsa:642987
UCSCiuc011cvh.4 human [C9JQI7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
642987
DisGeNETi642987

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM232
HGNCiHGNC:37270 TMEM232
HPAiHPA049386
neXtProtiNX_C9JQI7
OpenTargetsiENSG00000186952
PharmGKBiPA165660571

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG5N Eukaryota
ENOG4111R3E LUCA
GeneTreeiENSGT00390000014003
HOGENOMiHOG000054199
InParanoidiC9JQI7
OMAiLNMLYAS
OrthoDBi679293at2759
PhylomeDBiC9JQI7
TreeFamiTF336968

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM232 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
642987

Protein Ontology

More...
PROi
PR:C9JQI7

Gene expression databases

BgeeiENSG00000186952 Expressed in 114 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiC9JQI7 baseline and differential
GenevisibleiC9JQI7 HS

Family and domain databases

InterProiView protein in InterPro
IPR031747 TMEM232
PANTHERiPTHR28651 PTHR28651, 1 hit
PfamiView protein in Pfam
PF15877 TMEM232, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM232_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C9JQI7
Secondary accession number(s): B4DKF4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: May 8, 2019
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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