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Protein
Submitted name:

Insulin

Gene

INS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneSAAS annotation
Biological processCarbohydrate metabolism, Glucose metabolismSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
InsulinImported
Gene namesi
Name:INSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000254647.6
HGNCiHGNC:6081 INS

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000254647

Protein family/group databases

Allergomei2121 Hom s Insulin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500299726425 – 92Sequence analysisAdd BLAST68

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiC9JNR5
PRIDEiC9JNR5

Expressioni

Gene expression databases

BgeeiENSG00000254647 Expressed in 72 organ(s), highest expression level in type B pancreatic cell
ExpressionAtlasiC9JNR5 baseline and differential

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliC9JNR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 86IlGFInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the insulin family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

C9JNR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY
60 70 80 90
TPKTRREAED LQAGELLQLD AARRQPHTRR LLHRERWNKA LE
Length:92
Mass (Da):10,631
Last modified:November 3, 2009 - v1
Checksum:i4E099F7685F10D39
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P01308INS_HUMAN
Insulin
INS
110Annotation score:
A6XGL2A6XGL2_HUMAN
Insulin
INS
98Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei92Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132217 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000421783; ENSP00000408400; ENSG00000254647
UCSCiuc057xwk.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132217 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9JNR5
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei2121 Hom s Insulin

Proteomic databases

PeptideAtlasiC9JNR5
PRIDEiC9JNR5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421783; ENSP00000408400; ENSG00000254647
UCSCiuc057xwk.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000254647.6
HGNCiHGNC:6081 INS
OpenTargetsiENSG00000254647
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440

Miscellaneous databases

ChiTaRSiINS human

Gene expression databases

BgeeiENSG00000254647 Expressed in 72 organ(s), highest expression level in type B pancreatic cell
ExpressionAtlasiC9JNR5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JNR5_HUMAN
AccessioniPrimary (citable) accession number: C9JNR5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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