ZNF878

Functionⁱ

May be involved in transcriptional regulation.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	122 – 137	C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST	16
Zinc fingerⁱ	143 – 165	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	171 – 193	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	199 – 221	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	227 – 249	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	255 – 277	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	283 – 305	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	311 – 333	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	339 – 361	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	367 – 389	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	395 – 417	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	423 – 445	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	451 – 473	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	479 – 501	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	507 – 529	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 878
Gene namesⁱ	Name:ZNF878
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000257446.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:37246 ZNF878
neXtProtⁱ	NX_C9JN71

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000257446
PharmGKBⁱ	PA165395055

Polymorphism and mutation databases

BioMutaⁱ	ZNF878

BioMutaⁱ

ZNF878

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000393952	1 – 531	Zinc finger protein 878Add BLAST		531

Proteomic databases

EPDⁱ	C9JN71
PaxDbⁱ	C9JN71
PRIDEⁱ	C9JN71
ProteomicsDBⁱ	10937

PTM databases

iPTMnetⁱ	C9JN71
PhosphoSitePlusⁱ	C9JN71

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer

Bgeeⁱ

ENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052735

HPAⁱ

HPA052735

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000447931

STRINGⁱ

9606.ENSP00000447931

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	C9JN71
SMRⁱ	C9JN71
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 90	KRABPROSITE-ProRule annotationAdd BLAST		87

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	122 – 137	C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST	16
Zinc fingerⁱ	143 – 165	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	171 – 193	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	199 – 221	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	227 – 249	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	255 – 277	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	283 – 305	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	311 – 333	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	339 – 361	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	367 – 389	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	395 – 417	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	423 – 445	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	451 – 473	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	479 – 501	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	507 – 529	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119089
HOGENOMⁱ	HOG000234617
InParanoidⁱ	C9JN71
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	QLKMHER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	C9JN71
TreeFamⁱ	TF338854

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 14 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 8 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 14 hits PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

C9JN71-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSVAFEDVA VNFTQEEWAL LDPSQKNLYR EVMQETLRNL TSIGKKWNNQ 
        60         70         80         90        100
YIEDEHQNPR RNLRRLIGER LSESKESHQH GEVLTQVPDD TLKKKTPGVQ 
       110        120        130        140        150
SYESSVCGEI GIGLSSLNRH LRAFSYSSSL AIHGRTHTGE KPYECKECGK 
       160        170        180        190        200
AFRFPSSVRR HERIHSAKKP YECKQCGKAF SFPSSVRRHE RIHSAKKPYE 
       210        220        230        240        250
CKQCGKALSY LVSFQTHMRM HTGERPHKCN ICGKAFFSPS SLKRHEKSHT 
       260        270        280        290        300
GEKRYKCKQC DKAFNCPSSF QYHERTHSGE KPYECTQCRK AFRSVKYLRV 
       310        320        330        340        350
HERKHTGEKP YECKLCGKGF ISSTSFRYHE KTHTGEKPYE CKKCVKAFSF 
       360        370        380        390        400
VKDLRIHERT HTGEKPFECK QCGKTFTSSN SFHYHERTHT GEKPYECKQC 
       410        420        430        440        450
GKAFRSASVL QKHIRTHTGE KPYGCKQCGK VFRVASQLKM HERTHTGEKP 
       460        470        480        490        500
YECKQCGKAF ISSNSIRYHK RTHTGEKPYK CKQCGKAFIS SNSFLYHERI 
       510        520        530 
HTGEKPYECK QCGKAFRSAS ILQKHVRTHA G

Length:531

Mass (Da):61,540

Last modified:March 8, 2011 - v2

Checksum:ⁱ5E11E87B22256BF5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC022415 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45984.2
NCBI Reference Sequences More...RefSeqⁱ	NP_001073873.2, NM_001080404.2
UniGeneⁱ	Hs.704229

Genome annotation databases

Ensemblⁱ	ENST00000547628; ENSP00000447931; ENSG00000257446
GeneIDⁱ	729747
KEGGⁱ	hsa:729747
UCSC genome browser More...UCSCⁱ	uc021upl.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
C9JN71	Uncharacterized protein		MACMU		578	UniRef90_C9JN71
ZNF878 isoform 1		PONAB		531
Uncharacterized protein		PANPA		531
Zinc finger protein 878		GORGO		531
UPI0007DC6652		HUMAN		567
+3

Protein	Similar proteins		Species	Score	Length	Source
C9JN71	Zinc finger protein 431		MOUSE		526	UniRef50_E9QAG8
Uncharacterized protein		MACFA		503
Zinc finger protein 878		PANTR		503
Zinc finger protein 878		MACNE		503
Uncharacterized protein		MACMU		503
+90

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC022415 Genomic DNA No translation available.
CCDSⁱ	CCDS45984.2
RefSeqⁱ	NP_001073873.2, NM_001080404.2
UniGeneⁱ	Hs.704229

3D structure databases

ProteinModelPortalⁱ	C9JN71
SMRⁱ	C9JN71
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000447931

STRINGⁱ

9606.ENSP00000447931

PTM databases

iPTMnetⁱ	C9JN71
PhosphoSitePlusⁱ	C9JN71

Polymorphism and mutation databases

BioMutaⁱ	ZNF878

BioMutaⁱ

ZNF878

Proteomic databases

EPDⁱ	C9JN71
PaxDbⁱ	C9JN71
PRIDEⁱ	C9JN71
ProteomicsDBⁱ	10937

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000547628; ENSP00000447931; ENSG00000257446
GeneIDⁱ	729747
KEGGⁱ	hsa:729747
UCSCⁱ	uc021upl.2 human

Organism-specific databases

CTDⁱ	729747
EuPathDBⁱ	HostDB:ENSG00000257446.3
GeneCardsⁱ	ZNF878
HGNCⁱ	HGNC:37246 ZNF878
HPAⁱ	HPA052735
neXtProtⁱ	NX_C9JN71
OpenTargetsⁱ	ENSG00000257446
PharmGKBⁱ	PA165395055
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000119089
HOGENOMⁱ	HOG000234617
InParanoidⁱ	C9JN71
KOⁱ	K09228
OMAⁱ	QLKMHER
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	C9JN71
TreeFamⁱ	TF338854

Miscellaneous databases

GenomeRNAiⁱ	729747
Protein Ontology More...PROⁱ	PR:C9JN71

Gene expression databases

Bgeeⁱ	ENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer

Bgeeⁱ

ENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 14 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 8 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 14 hits PS50157 ZINC_FINGER_C2H2_2, 15 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN878_HUMAN
Accessionⁱ	C9JN71Primary (citable) accession number: C9JN71
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 18, 2010
	Last sequence update:	March 8, 2011
	Last modified:	November 7, 2018
	This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - C9JN71 (ZN878_HUMAN)

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Zinc finger protein 878

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ