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Protein

Zinc finger protein 878

Gene

ZNF878

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri122 – 137C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST16
Zinc fingeri143 – 165C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 878
Gene namesi
Name:ZNF878
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000257446.3
HGNCiHGNC:37246 ZNF878
neXtProtiNX_C9JN71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000257446
PharmGKBiPA165395055

Polymorphism and mutation databases

BioMutaiZNF878

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939521 – 531Zinc finger protein 878Add BLAST531

Proteomic databases

EPDiC9JN71
PaxDbiC9JN71
PRIDEiC9JN71
ProteomicsDBi10937

PTM databases

iPTMnetiC9JN71
PhosphoSitePlusiC9JN71

Expressioni

Gene expression databases

BgeeiENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer

Organism-specific databases

HPAiHPA052735

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000447931

Structurei

3D structure databases

ProteinModelPortaliC9JN71
SMRiC9JN71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 90KRABPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri122 – 137C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST16
Zinc fingeri143 – 165C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
InParanoidiC9JN71
KOiK09228
OMAiQLKMHER
OrthoDBiEOG091G02KC
PhylomeDBiC9JN71
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequencei

Sequence statusi: Complete.

C9JN71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSVAFEDVA VNFTQEEWAL LDPSQKNLYR EVMQETLRNL TSIGKKWNNQ
60 70 80 90 100
YIEDEHQNPR RNLRRLIGER LSESKESHQH GEVLTQVPDD TLKKKTPGVQ
110 120 130 140 150
SYESSVCGEI GIGLSSLNRH LRAFSYSSSL AIHGRTHTGE KPYECKECGK
160 170 180 190 200
AFRFPSSVRR HERIHSAKKP YECKQCGKAF SFPSSVRRHE RIHSAKKPYE
210 220 230 240 250
CKQCGKALSY LVSFQTHMRM HTGERPHKCN ICGKAFFSPS SLKRHEKSHT
260 270 280 290 300
GEKRYKCKQC DKAFNCPSSF QYHERTHSGE KPYECTQCRK AFRSVKYLRV
310 320 330 340 350
HERKHTGEKP YECKLCGKGF ISSTSFRYHE KTHTGEKPYE CKKCVKAFSF
360 370 380 390 400
VKDLRIHERT HTGEKPFECK QCGKTFTSSN SFHYHERTHT GEKPYECKQC
410 420 430 440 450
GKAFRSASVL QKHIRTHTGE KPYGCKQCGK VFRVASQLKM HERTHTGEKP
460 470 480 490 500
YECKQCGKAF ISSNSIRYHK RTHTGEKPYK CKQCGKAFIS SNSFLYHERI
510 520 530
HTGEKPYECK QCGKAFRSAS ILQKHVRTHA G
Length:531
Mass (Da):61,540
Last modified:March 8, 2011 - v2
Checksum:i5E11E87B22256BF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022415 Genomic DNA No translation available.
CCDSiCCDS45984.2
RefSeqiNP_001073873.2, NM_001080404.2
UniGeneiHs.704229

Genome annotation databases

EnsembliENST00000547628; ENSP00000447931; ENSG00000257446
GeneIDi729747
KEGGihsa:729747
UCSCiuc021upl.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022415 Genomic DNA No translation available.
CCDSiCCDS45984.2
RefSeqiNP_001073873.2, NM_001080404.2
UniGeneiHs.704229

3D structure databases

ProteinModelPortaliC9JN71
SMRiC9JN71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000447931

PTM databases

iPTMnetiC9JN71
PhosphoSitePlusiC9JN71

Polymorphism and mutation databases

BioMutaiZNF878

Proteomic databases

EPDiC9JN71
PaxDbiC9JN71
PRIDEiC9JN71
ProteomicsDBi10937

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000547628; ENSP00000447931; ENSG00000257446
GeneIDi729747
KEGGihsa:729747
UCSCiuc021upl.2 human

Organism-specific databases

CTDi729747
EuPathDBiHostDB:ENSG00000257446.3
GeneCardsiZNF878
HGNCiHGNC:37246 ZNF878
HPAiHPA052735
neXtProtiNX_C9JN71
OpenTargetsiENSG00000257446
PharmGKBiPA165395055
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
InParanoidiC9JN71
KOiK09228
OMAiQLKMHER
OrthoDBiEOG091G02KC
PhylomeDBiC9JN71
TreeFamiTF338854

Miscellaneous databases

GenomeRNAii729747
PROiPR:C9JN71

Gene expression databases

BgeeiENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN878_HUMAN
AccessioniPrimary (citable) accession number: C9JN71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: March 8, 2011
Last modified: November 7, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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