UniProtKB - C9JN71 (ZN878_HUMAN)
Protein
Zinc finger protein 878
Gene
ZNF878
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 122 – 137 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 16 | |
Zinc fingeri | 143 – 165 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 171 – 193 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 199 – 221 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 227 – 249 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 277 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 283 – 305 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 311 – 333 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 339 – 361 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 395 – 417 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 423 – 445 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 451 – 473 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 479 – 501 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 507 – 529 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 878 |
Gene namesi | Name:ZNF878 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000257446.3 |
HGNCi | HGNC:37246 ZNF878 |
neXtProti | NX_C9JN71 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000257446 |
PharmGKBi | PA165395055 |
Polymorphism and mutation databases
BioMutai | ZNF878 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000393952 | 1 – 531 | Zinc finger protein 878Add BLAST | 531 |
Proteomic databases
EPDi | C9JN71 |
jPOSTi | C9JN71 |
PaxDbi | C9JN71 |
PRIDEi | C9JN71 |
ProteomicsDBi | 10937 |
PTM databases
iPTMneti | C9JN71 |
PhosphoSitePlusi | C9JN71 |
Expressioni
Gene expression databases
Bgeei | ENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer |
Organism-specific databases
HPAi | HPA052735 |
Interactioni
Protein-protein interaction databases
IntActi | C9JN71, 1 interactor |
STRINGi | 9606.ENSP00000447931 |
Structurei
3D structure databases
ProteinModelPortali | C9JN71 |
SMRi | C9JN71 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 90 | KRABPROSITE-ProRule annotationAdd BLAST | 87 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 122 – 137 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 16 | |
Zinc fingeri | 143 – 165 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 171 – 193 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 199 – 221 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 227 – 249 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 277 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 283 – 305 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 311 – 333 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 339 – 361 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 395 – 417 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 423 – 445 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 451 – 473 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 479 – 501 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 507 – 529 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000153317 |
HOGENOMi | HOG000234617 |
InParanoidi | C9JN71 |
KOi | K09228 |
OMAi | QLKMHER |
OrthoDBi | 1318335at2759 |
PhylomeDBi | C9JN71 |
TreeFami | TF338854 |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 14 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 14 hits PS50157 ZINC_FINGER_C2H2_2, 15 hits |
i Sequence
Sequence statusi: Complete.
C9JN71-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSVAFEDVA VNFTQEEWAL LDPSQKNLYR EVMQETLRNL TSIGKKWNNQ
60 70 80 90 100
YIEDEHQNPR RNLRRLIGER LSESKESHQH GEVLTQVPDD TLKKKTPGVQ
110 120 130 140 150
SYESSVCGEI GIGLSSLNRH LRAFSYSSSL AIHGRTHTGE KPYECKECGK
160 170 180 190 200
AFRFPSSVRR HERIHSAKKP YECKQCGKAF SFPSSVRRHE RIHSAKKPYE
210 220 230 240 250
CKQCGKALSY LVSFQTHMRM HTGERPHKCN ICGKAFFSPS SLKRHEKSHT
260 270 280 290 300
GEKRYKCKQC DKAFNCPSSF QYHERTHSGE KPYECTQCRK AFRSVKYLRV
310 320 330 340 350
HERKHTGEKP YECKLCGKGF ISSTSFRYHE KTHTGEKPYE CKKCVKAFSF
360 370 380 390 400
VKDLRIHERT HTGEKPFECK QCGKTFTSSN SFHYHERTHT GEKPYECKQC
410 420 430 440 450
GKAFRSASVL QKHIRTHTGE KPYGCKQCGK VFRVASQLKM HERTHTGEKP
460 470 480 490 500
YECKQCGKAF ISSNSIRYHK RTHTGEKPYK CKQCGKAFIS SNSFLYHERI
510 520 530
HTGEKPYECK QCGKAFRSAS ILQKHVRTHA G
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022415 Genomic DNA No translation available. |
CCDSi | CCDS45984.2 |
RefSeqi | NP_001073873.2, NM_001080404.2 |
UniGenei | Hs.704229 |
Genome annotation databases
Ensembli | ENST00000547628; ENSP00000447931; ENSG00000257446 |
GeneIDi | 729747 |
KEGGi | hsa:729747 |
UCSCi | uc021upl.2 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022415 Genomic DNA No translation available. |
CCDSi | CCDS45984.2 |
RefSeqi | NP_001073873.2, NM_001080404.2 |
UniGenei | Hs.704229 |
3D structure databases
ProteinModelPortali | C9JN71 |
SMRi | C9JN71 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | C9JN71, 1 interactor |
STRINGi | 9606.ENSP00000447931 |
PTM databases
iPTMneti | C9JN71 |
PhosphoSitePlusi | C9JN71 |
Polymorphism and mutation databases
BioMutai | ZNF878 |
Proteomic databases
EPDi | C9JN71 |
jPOSTi | C9JN71 |
PaxDbi | C9JN71 |
PRIDEi | C9JN71 |
ProteomicsDBi | 10937 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000547628; ENSP00000447931; ENSG00000257446 |
GeneIDi | 729747 |
KEGGi | hsa:729747 |
UCSCi | uc021upl.2 human |
Organism-specific databases
CTDi | 729747 |
EuPathDBi | HostDB:ENSG00000257446.3 |
GeneCardsi | ZNF878 |
HGNCi | HGNC:37246 ZNF878 |
HPAi | HPA052735 |
neXtProti | NX_C9JN71 |
OpenTargetsi | ENSG00000257446 |
PharmGKBi | PA165395055 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000153317 |
HOGENOMi | HOG000234617 |
InParanoidi | C9JN71 |
KOi | K09228 |
OMAi | QLKMHER |
OrthoDBi | 1318335at2759 |
PhylomeDBi | C9JN71 |
TreeFami | TF338854 |
Miscellaneous databases
GenomeRNAii | 729747 |
PROi | PR:C9JN71 |
Gene expression databases
Bgeei | ENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 14 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 14 hits PS50157 ZINC_FINGER_C2H2_2, 15 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | ZN878_HUMAN | |
Accessioni | C9JN71Primary (citable) accession number: C9JN71 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 18, 2010 |
Last sequence update: | March 8, 2011 | |
Last modified: | February 13, 2019 | |
This is version 84 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM