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UniProtKB - C9JN71 (ZN878_HUMAN)

Protein

Zinc finger protein 878

Gene

ZNF878

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri122 – 137C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST16
Zinc fingeri143 – 165C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 878
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF878
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000257446.3

Human Gene Nomenclature Database

More...HGNCi		HGNC:37246 ZNF878

neXtProt; the human protein knowledge platform

More...neXtProti		NX_C9JN71

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000257446

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165395055

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF878

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003939521 – 531Zinc finger protein 878Add BLAST531

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		C9JN71

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		C9JN71

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		C9JN71

PRoteomics IDEntifications database

More...PRIDEi		C9JN71

ProteomicsDB human proteome resource

More...ProteomicsDBi		10937

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		C9JN71

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		C9JN71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA052735

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000447931

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		C9JN71

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		C9JN71

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 90KRABPROSITE-ProRule annotationAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri122 – 137C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST16
Zinc fingeri143 – 165C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153317

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		C9JN71

KEGG Orthology (KO)

More...KOi		K09228

Identification of Orthologs from Complete Genome Data

More...OMAi		QLKMHER

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		C9JN71

TreeFam database of animal gene trees

More...TreeFami		TF338854

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C9JN71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSVAFEDVA VNFTQEEWAL LDPSQKNLYR EVMQETLRNL TSIGKKWNNQ 
        60         70         80         90        100
YIEDEHQNPR RNLRRLIGER LSESKESHQH GEVLTQVPDD TLKKKTPGVQ 
       110        120        130        140        150
SYESSVCGEI GIGLSSLNRH LRAFSYSSSL AIHGRTHTGE KPYECKECGK 
       160        170        180        190        200
AFRFPSSVRR HERIHSAKKP YECKQCGKAF SFPSSVRRHE RIHSAKKPYE 
       210        220        230        240        250
CKQCGKALSY LVSFQTHMRM HTGERPHKCN ICGKAFFSPS SLKRHEKSHT 
       260        270        280        290        300
GEKRYKCKQC DKAFNCPSSF QYHERTHSGE KPYECTQCRK AFRSVKYLRV 
       310        320        330        340        350
HERKHTGEKP YECKLCGKGF ISSTSFRYHE KTHTGEKPYE CKKCVKAFSF 
       360        370        380        390        400
VKDLRIHERT HTGEKPFECK QCGKTFTSSN SFHYHERTHT GEKPYECKQC 
       410        420        430        440        450
GKAFRSASVL QKHIRTHTGE KPYGCKQCGK VFRVASQLKM HERTHTGEKP 
       460        470        480        490        500
YECKQCGKAF ISSNSIRYHK RTHTGEKPYK CKQCGKAFIS SNSFLYHERI 
       510        520        530 
HTGEKPYECK QCGKAFRSAS ILQKHVRTHA G
Length:531
Mass (Da):61,540
Last modified:March 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E11E87B22256BF5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC022415 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45984.2

NCBI Reference Sequences

More...RefSeqi		NP_001073873.2, NM_001080404.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.704229

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000547628; ENSP00000447931; ENSG00000257446

Database of genes from NCBI RefSeq genomes

More...GeneIDi		729747

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:729747

UCSC genome browser

More...UCSCi		uc021upl.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022415 Genomic DNA No translation available.
CCDSiCCDS45984.2
RefSeqiNP_001073873.2, NM_001080404.2
UniGeneiHs.704229

3D structure databases

ProteinModelPortaliC9JN71
SMRiC9JN71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000447931

PTM databases

iPTMnetiC9JN71
PhosphoSitePlusiC9JN71

Polymorphism and mutation databases

BioMutaiZNF878

Proteomic databases

EPDiC9JN71
jPOSTiC9JN71
PaxDbiC9JN71
PRIDEiC9JN71
ProteomicsDBi10937

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000547628; ENSP00000447931; ENSG00000257446
GeneIDi729747
KEGGihsa:729747
UCSCiuc021upl.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		729747
EuPathDBiHostDB:ENSG00000257446.3

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF878
HGNCiHGNC:37246 ZNF878
HPAiHPA052735
neXtProtiNX_C9JN71
OpenTargetsiENSG00000257446
PharmGKBiPA165395055

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000153317
HOGENOMiHOG000234617
InParanoidiC9JN71
KOiK09228
OMAiQLKMHER
OrthoDBi1318335at2759
PhylomeDBiC9JN71
TreeFamiTF338854

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		729747

Protein Ontology

More...PROi		PR:C9JN71

Gene expression databases

BgeeiENSG00000257446 Expressed in 76 organ(s), highest expression level in lower esophagus muscularis layer

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN878_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C9JN71
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: March 8, 2011
Last modified: January 16, 2019
This is version 83 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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