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Entry version 78 (02 Jun 2021)
Sequence version 3 (29 Oct 2014)
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Protein
Submitted name:

Thrombospondin type-1 domain-containing protein 7B

Gene

THSD7B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Thrombospondin type-1 domain-containing protein 7BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THSD7BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29348, THSD7B

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000144229.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1527 – 1551HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000144229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
C9JKN6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
10599

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144229, Expressed in pigmented layer of retina and 130 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
C9JKN6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
C9JKN6, 24 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 198TSP1_spondinInterPro annotationAdd BLAST50
Domaini306 – 358TSP1_spondinInterPro annotationAdd BLAST53
Domaini571 – 629TSP1_spondinInterPro annotationAdd BLAST59
Domaini707 – 764TSP1_spondinInterPro annotationAdd BLAST58
Domaini1219 – 1272TSP1_spondinInterPro annotationAdd BLAST54
Domaini1342 – 1401TSP1_spondinInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1554 – 1577DisorderedSequence analysisAdd BLAST24

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159262

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCKINNE

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR044004, TSP1_spondin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19028, TSP1_spondin, 6 hits
PF00090, TSP_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50092, TSP1, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

C9JKN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHNTADEVVL YHKLAGPWGR CTGDCGPGGV QSRAVWCFHV DGWTSHLSNC
60 70 80 90 100
GESNRPPKER SCFRVCDWHS DLFQWEVSDW HHCVLVPYAR GEVKPRTAEC
110 120 130 140 150
VTAQHGLQHR MVRCIQKLNR TVVANEICEH FALQPPTEQA CLIPCPRDCV
160 170 180 190 200
VSEFLPWSNC SKGCGKKLQH RTRAVIAPPL FGGLQCPNLT ESRACDAPIS
210 220 230 240 250
CPLGEEEYTF SLKVGPWSKC RLPHLKEINP SGRTVLDFNS DSNERVTFKH
260 270 280 290 300
QSYKAHHHSK SWAIEIGYQT RQVSCTRSDG QNAMLSLCLQ DSFPLTVQSC
310 320 330 340 350
IMPKDCETSQ WSSWSPCSKT CRSGSLLPGF RSRSRNVKHM AIGGGKECPE
360 370 380 390 400
LLEKEACIVE GELLQQCPRY SWRTSEWKEC QVSLLLEQQD PHWHVTGPVC
410 420 430 440 450
GGGIQTREVY CAQSVPAAAA LRAKEVSRPV EKALCVGPAP LPSQLCNIPC
460 470 480 490 500
STDCIVSSWS AWGLCIHENC HDPQGKKGFR TRQRHVLMES TGPAGHCPHL
510 520 530 540 550
VESVPCEDPM CYRWLASEGI CFPDHGKCGL GHRILKAVCQ NDRGEDVSGS
560 570 580 590 600
LCPVPPPPER KSCEIPCRMD CVLSEWTEWS SCSQSCSNKN SDGKQTRSRT
610 620 630 640 650
ILALAGEGGK PCPPSQALQE HRLCNDHSCM QLHWETSPWG PCSEDTLVTA
660 670 680 690 700
LNATIGWNGE ATCGVGIQTR RVFCVKSHVG QVMTKRCPDS TRPETVRPCF
710 720 730 740 750
LPCKKDCIVT AFSEWTPCPR MCQAGNATVK QSRYRIIIQE AANGGQECPD
760 770 780 790 800
TLYEERECED VSLCPVYRWK PQKWSPCILV PESVWQGITG SSEACGKGLQ
810 820 830 840 850
TRAVSCISDD NRSAEMMECL KQTNGMPLLV QECTVPCRED CTFTAWSKFT
860 870 880 890 900
PCSTNCEATK SRRRQLTGKS RKKEKCQDSD LYPLVETELC PCDEFISQPY
910 920 930 940 950
GNWSDCILPE GRREPHRGLR VQADSKECGE GLRFRAVACS DKNGRPVDPS
960 970 980 990 1000
FCSSSGYIQE KCVIPCPFDC KLSDWSSWGS CSSSCGIGVR IRSKWLKEKP
1010 1020 1030 1040 1050
YNGGRPCPKL DLKNQAQVHE AVPCYSECNQ YSWVVEHWSS CKINNELRSL
1060 1070 1080 1090 1100
RCGGGTQSRK IRCVNTADGE GGAVDSNLCN QDEIPPETQS CSLMCPNECV
1110 1120 1130 1140 1150
MSEWGLWSKC PQSCDPHTMQ RRTRHLLRPS LNSRTCAEDS QVQPCLLNEN
1160 1170 1180 1190 1200
CFQFQYNLTE WSTCQLSENA PCGQGVRTRL LSCVCSDGKP VSMDQCEQHN
1210 1220 1230 1240 1250
LEKPQRMSIP CLVECVVNCQ LSGWTAWTEC SQTCGHGGRM SRTRFIIMPT
1260 1270 1280 1290 1300
QGEGRPCPTE LTQEKTCPVT PCYSWVLGNW SACKLEGGDC GEGVQIRSLS
1310 1320 1330 1340 1350
CMVHSGSISH AAGRVEDALC GEMPFQDSIL KQLCSVPCPG DCHLTEWSEW
1360 1370 1380 1390 1400
STCELTCIDG RSFETVGRQS RSRTFIIQSF ENQDSCPQQV LETRPCTGGK
1410 1420 1430 1440 1450
CYHYTWKASL WNNNERTVWC QRSDGVNVTG GCSPQARPAA IRQCIPACRK
1460 1470 1480 1490 1500
PFSYCTQGGV CGCEKGYTEI MKSNGFLDYC MKVPGSEDKK ADVKNLSGKN
1510 1520 1530 1540 1550
RPVNSKIHDI FKGWSLQPLD PDGRVKIWVY GVSGGAFLIM IFLIFTSYLV
1560 1570
CKKPKPHQST PPQQKPLTLA YDGDLDM
Length:1,577
Mass (Da):175,654
Last modified:October 29, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB19E3373AF8ABB84
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9C0I4THS7B_HUMAN
Thrombospondin type-1 domain-contai...
THSD7B KIAA1679
1,606Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5K1VW52A0A5K1VW52_HUMAN
Thrombospondin type-1 domain-contai...
THSD7B
1,608Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMU2R4GMU2_HUMAN
Thrombospondin type-1 domain-contai...
THSD7B
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010100 Genomic DNA No translation available.
AC010873 Genomic DNA No translation available.
AC011231 Genomic DNA No translation available.
AC012000 Genomic DNA No translation available.
AC016679 Genomic DNA No translation available.
AC017082 Genomic DNA No translation available.
AC019067 Genomic DNA No translation available.
KF456714 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000413152; ENSP00000413841; ENSG00000144229

UCSC genome browser

More...
UCSCi
uc061ocm.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010100 Genomic DNA No translation available.
AC010873 Genomic DNA No translation available.
AC011231 Genomic DNA No translation available.
AC012000 Genomic DNA No translation available.
AC016679 Genomic DNA No translation available.
AC017082 Genomic DNA No translation available.
AC019067 Genomic DNA No translation available.
KF456714 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiC9JKN6, 24 interactors

Proteomic databases

PRIDEiC9JKN6
ProteomicsDBi10599

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62318, 9 antibodies

Genome annotation databases

EnsembliENST00000413152; ENSP00000413841; ENSG00000144229
UCSCiuc061ocm.1, human

Organism-specific databases

HGNCiHGNC:29348, THSD7B
OpenTargetsiENSG00000144229
VEuPathDBiHostDB:ENSG00000144229.11

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000159262
OMAiPCKINNE

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
THSD7B, human

Gene expression databases

BgeeiENSG00000144229, Expressed in pigmented layer of retina and 130 other tissues
ExpressionAtlasiC9JKN6, baseline and differential

Family and domain databases

Gene3Di2.20.100.10, 11 hits
InterProiView protein in InterPro
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR044004, TSP1_spondin_dom
PfamiView protein in Pfam
PF19028, TSP1_spondin, 6 hits
PF00090, TSP_1, 2 hits
SMARTiView protein in SMART
SM00209, TSP1, 16 hits
SUPFAMiSSF82895, SSF82895, 12 hits
PROSITEiView protein in PROSITE
PS50092, TSP1, 13 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC9JKN6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C9JKN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 29, 2014
Last modified: June 2, 2021
This is version 78 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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