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Protein
Submitted name:

Hepatocyte growth factor receptor

Gene

MET

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte growth factor receptorImported
Gene namesi
Name:METImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105976.14
HGNCiHGNC:7029 MET

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105976

PTM / Processingi

Proteomic databases

MaxQBiC9JKM5
PeptideAtlasiC9JKM5
PRIDEiC9JKM5

Expressioni

Gene expression databases

BgeeiENSG00000105976 Expressed in 207 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiC9JKM5 baseline and differential

Structurei

3D structure databases

SMRiC9JKM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 190SemaInterPro annotationAdd BLAST145

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
KOG3610 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00810000125384

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF01403 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

C9JKM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSKSKSLAE CFPYDKPLIM KAPAVLAPGI LVLLFTLVQR SNGECKEALA
60 70 80 90 100
KSEMNVNMKY QLPNFTAETP IQNVILHEHH IFLGATNYIY VLNEEDLQKV
110 120 130 140 150
AEYKTGPVLE HPDCFPCQDC SSKANLSGGV WKDNINMALV VDTYYDDQLI
160 170 180 190
SCGSVNRGTC QRHVFPHNHT ADIQSEVHCI FSPQIEEPSQ
Length:190
Mass (Da):21,298
Last modified:November 3, 2009 - v1
Checksum:iA2AC24F36908545F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P08581MET_HUMAN
Hepatocyte growth factor receptor
MET
1,390Annotation score:
H7C130H7C130_HUMAN
Hepatocyte growth factor receptor
MET
158Annotation score:
H7C174H7C174_HUMAN
Hepatocyte growth factor receptor
MET
214Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei190Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002080 Genomic DNA No translation available.
AC002543 Genomic DNA No translation available.
AC004416 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000456159; ENSP00000413857; ENSG00000105976
UCSCiuc064hhk.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002080 Genomic DNA No translation available.
AC002543 Genomic DNA No translation available.
AC004416 Genomic DNA No translation available.

3D structure databases

SMRiC9JKM5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiC9JKM5
PeptideAtlasiC9JKM5
PRIDEiC9JKM5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456159; ENSP00000413857; ENSG00000105976
UCSCiuc064hhk.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000105976.14
HGNCiHGNC:7029 MET
OpenTargetsiENSG00000105976
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
KOG3610 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00810000125384

Miscellaneous databases

ChiTaRSiMET human

Gene expression databases

BgeeiENSG00000105976 Expressed in 207 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiC9JKM5 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF01403 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JKM5_HUMAN
AccessioniPrimary (citable) accession number: C9JKM5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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