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Protein
Submitted name:

Voltage-dependent anion-selective channel protein 1

Gene

VDAC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent anion-selective channel protein 1Imported
Gene namesi
Name:VDAC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000213585.10
HGNCiHGNC:12669 VDAC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213585

PTM / Processingi

Proteomic databases

EPDiC9JI87
PeptideAtlasiC9JI87
PRIDEiC9JI87

Expressioni

Gene expression databases

BgeeiENSG00000213585 Expressed in 226 organ(s), highest expression level in biceps brachii
ExpressionAtlasiC9JI87 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9JI87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3126 Eukaryota
ENOG410ZBK1 LUCA
GeneTreeiENSGT00390000011336
HOGENOMiHOG000188277

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
IPR030270 VDAC1
PANTHERiPTHR11743 PTHR11743, 1 hit
PTHR11743:SF13 PTHR11743:SF13, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
PRINTSiPR00185 EUKARYTPORIN

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

C9JI87-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE
60 70 80 90 100
TTKVTGSLET KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD
110 120 130 140 150
SSFSPNTGKK NAKIKTGYKR EHINLGCDMD FDIAGPSIRG ALVLGYEGWL
160 170 180
AGYQMNFETA KSRVTQSNFA VGYKTDEFQL HTN
Length:183
Mass (Da):20,275
Last modified:October 5, 2016 - v6
Checksum:i777260496C84E04C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P21796VDAC1_HUMAN
Voltage-dependent anion-selective c...
VDAC1 VDAC
283Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei183Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008608 Genomic DNA No translation available.
AC025177 Genomic DNA No translation available.
KC877121 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000425992; ENSP00000390129; ENSG00000213585
UCSCiuc063gzf.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008608 Genomic DNA No translation available.
AC025177 Genomic DNA No translation available.
KC877121 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9JI87
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiC9JI87
PeptideAtlasiC9JI87
PRIDEiC9JI87

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000425992; ENSP00000390129; ENSG00000213585
UCSCiuc063gzf.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000213585.10
HGNCiHGNC:12669 VDAC1
OpenTargetsiENSG00000213585
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3126 Eukaryota
ENOG410ZBK1 LUCA
GeneTreeiENSGT00390000011336
HOGENOMiHOG000188277

Miscellaneous databases

ChiTaRSiVDAC1 human

Gene expression databases

BgeeiENSG00000213585 Expressed in 226 organ(s), highest expression level in biceps brachii
ExpressionAtlasiC9JI87 baseline and differential

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
IPR030270 VDAC1
PANTHERiPTHR11743 PTHR11743, 1 hit
PTHR11743:SF13 PTHR11743:SF13, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
PRINTSiPR00185 EUKARYTPORIN
ProtoNetiSearch...

Entry informationi

Entry nameiC9JI87_HUMAN
AccessioniPrimary (citable) accession number: C9JI87
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 5, 2016
Last modified: October 10, 2018
This is version 76 of the entry and version 6 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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