UniProtKB - C9JH25 (PRRT4_HUMAN)
Protein
Proline-rich transmembrane protein 4
Gene
PRRT4
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Proline-rich transmembrane protein 4 |
Gene namesi | Name:PRRT4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:37280, PRRT4 |
neXtProti | NX_C9JH25 |
VEuPathDBi | HostDB:ENSG00000224940.8 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 370 – 390 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 392 – 412 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 430 – 450 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 467 – 487 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 500 – 520 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000224940 |
PharmGKBi | PA165618245 |
Miscellaneous databases
Pharosi | C9JH25, Tdark |
Genetic variation databases
BioMutai | PRRT4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000394498 | 24 – 899 | Proline-rich transmembrane protein 4Add BLAST | 876 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 641 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | C9JH25 |
MassIVEi | C9JH25 |
PaxDbi | C9JH25 |
PeptideAtlasi | C9JH25 |
PRIDEi | C9JH25 |
ProteomicsDBi | 10169 [C9JH25-1] 10170 [C9JH25-2] 10171 [C9JH25-3] |
PTM databases
GlyGeni | C9JH25, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | C9JH25 |
PhosphoSitePlusi | C9JH25 |
Expressioni
Gene expression databases
Bgeei | ENSG00000224940, Expressed in bone marrow and 103 other tissues |
ExpressionAtlasi | C9JH25, baseline and differential |
Organism-specific databases
HPAi | ENSG00000224940, Tissue enriched (bone) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 135071, 6 interactors |
STRINGi | 9606.ENSP00000415026 |
Miscellaneous databases
RNActi | C9JH25, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 373 – 516 | Leu-richAdd BLAST | 144 | |
Compositional biasi | 522 – 525 | Poly-Arg | 4 | |
Compositional biasi | 799 – 862 | Ser-richAdd BLAST | 64 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QU49, Eukaryota |
GeneTreei | ENSGT00730000111591 |
HOGENOMi | CLU_351937_0_0_1 |
InParanoidi | C9JH25 |
OMAi | CALAEPG |
OrthoDBi | 921831at2759 |
PhylomeDBi | C9JH25 |
Family and domain databases
InterProi | View protein in InterPro IPR043542, Prrt4-like |
PANTHERi | PTHR35578:SF1, PTHR35578:SF1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: C9JH25-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARHGCLGLG LFCCVLFAAT VGPQPTPSIP GAPATTLTPV PQSEASMLSL
60 70 80 90 100
NLGLNFKFHL RGPAAVWGSP VTETQPLSLG PGQEPGEEVA SGLRTDPLWE
110 120 130 140 150
LLVGSSGNSL TEWGSTEGGS KPRASSLLPE STSRRSGPSD GPTAPYQPRR
160 170 180 190 200
STVTWDTALM VTALPSSAPR PHQSELELKF DMALRAGAAP TLGHRTLPLL
210 220 230 240 250
PSLRASLAEI AGRLGPFGFF GTTLSPLRNF SGLSPPGETT STSSASGVSG
260 270 280 290 300
SLGFLGTTLS LPPYSLERKL SSPSPLDPAA SLSFASIATT SLDPTVPISG
310 320 330 340 350
PDDLSPPASL GNPSGQPECG PGSCSVGELP EREGQPPEAP RPLFFLTLEA
360 370 380 390 400
DWAEARARWG LAWEAHVYGV GALFGLVALL ALLALALLPW RCPPGAPCLA
410 420 430 440 450
LLDLLLLSAG TTRAFPLFYD AYGHRDRLPA LAWLLLQDLP LPCLAAGLGL
460 470 480 490 500
ACLLLARPRP PRCPTGLAAL LLLGLGLAAA AALGSAAHRP LRPLRLASRG
510 520 530 540 550
LHAFLAAFLS GLLLALSCWG GRRRRAGAPL GGSGFKGATP LPQGRSPFAP
560 570 580 590 600
RESWRRAART APVAGTFGLL SGALQGYEVL HALGYGGQSG LEGPWPWWAF
610 620 630 640 650
QLGLRLGEVG VALPLALLGL YPALCSPRVP PRCWAKLFRL SPGHAAPLLP
660 670 680 690 700
GGWVTGPPDK EPLGSAIARG DAELLQLCAL AGPGPDLLLQ GGGCRGFEGA
710 720 730 740 750
AANPAPSPAS SPCSDYTVDF RPPSPINLRR SIEEALCSEA LLAPGLFQGP
760 770 780 790 800
AFEDALPGLG LYRTASLGTG GRASERSGEA SGPAAPPELP SPGAWPAGSS
810 820 830 840 850
VSSGSFCGLS RDSSSMLLCS SPDRPPRCPL VCVLSPPRPS GSSPSLPASG
860 870 880 890
SYQALSPPSR DSPEPASELQ AEEALLQEQF LDACRQIDEL SVGSDTIDL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JVX5 | C9JVX5_HUMAN | HCG1651889, isoform CRA_d | PRRT4 hCG_1651889 | 479 | Annotation score: | ||
C9JQT1 | C9JQT1_HUMAN | Proline-rich transmembrane protein ... | PRRT4 | 208 | Annotation score: | ||
C9JWH6 | C9JWH6_HUMAN | Proline-rich transmembrane protein ... | PRRT4 | 205 | Annotation score: | ||
H7C4Q3 | H7C4Q3_HUMAN | Proline-rich transmembrane protein ... | PRRT4 | 419 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039274 | 370 – 575 | Missing in isoform 3. CuratedAdd BLAST | 206 | |
Alternative sequenceiVSP_039273 | 370 – 429 | VGALF…RDRLP → RLHRGLPPALPNQPATQHRG GPLQRGPACAWPLPGPCLRG RSAWARTLPHRLAGDRGQGQ in isoform 2. 1 PublicationAdd BLAST | 60 | |
Alternative sequenceiVSP_039275 | 430 – 899 | Missing in isoform 2. 1 PublicationAdd BLAST | 470 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010655 Genomic DNA No translation available. CH236947 Genomic DNA Translation: EAL24313.1 CH471070 Genomic DNA Translation: EAW83645.1 BC063892 mRNA No translation available. |
CCDSi | CCDS47698.2 [C9JH25-2] CCDS55160.1 [C9JH25-1] |
RefSeqi | NP_001108198.2, NM_001114726.2 [C9JH25-2] NP_001167635.1, NM_001174164.1 [C9JH25-1] XP_005250399.1, XM_005250342.3 [C9JH25-1] XP_005250400.1, XM_005250343.3 [C9JH25-1] XP_006716048.1, XM_006715985.3 [C9JH25-1] XP_016867694.1, XM_017012205.1 [C9JH25-1] XP_016867695.1, XM_017012206.1 [C9JH25-2] |
Genome annotation databases
Ensembli | ENST00000446477; ENSP00000415026; ENSG00000224940 [C9JH25-1] ENST00000489835; ENSP00000419296; ENSG00000224940 [C9JH25-2] ENST00000535159; ENSP00000445239; ENSG00000224940 [C9JH25-1] |
GeneIDi | 401399 |
KEGGi | hsa:401399 |
UCSCi | uc022akx.2, human [C9JH25-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010655 Genomic DNA No translation available. CH236947 Genomic DNA Translation: EAL24313.1 CH471070 Genomic DNA Translation: EAW83645.1 BC063892 mRNA No translation available. |
CCDSi | CCDS47698.2 [C9JH25-2] CCDS55160.1 [C9JH25-1] |
RefSeqi | NP_001108198.2, NM_001114726.2 [C9JH25-2] NP_001167635.1, NM_001174164.1 [C9JH25-1] XP_005250399.1, XM_005250342.3 [C9JH25-1] XP_005250400.1, XM_005250343.3 [C9JH25-1] XP_006716048.1, XM_006715985.3 [C9JH25-1] XP_016867694.1, XM_017012205.1 [C9JH25-1] XP_016867695.1, XM_017012206.1 [C9JH25-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 135071, 6 interactors |
STRINGi | 9606.ENSP00000415026 |
PTM databases
GlyGeni | C9JH25, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | C9JH25 |
PhosphoSitePlusi | C9JH25 |
Genetic variation databases
BioMutai | PRRT4 |
Proteomic databases
jPOSTi | C9JH25 |
MassIVEi | C9JH25 |
PaxDbi | C9JH25 |
PeptideAtlasi | C9JH25 |
PRIDEi | C9JH25 |
ProteomicsDBi | 10169 [C9JH25-1] 10170 [C9JH25-2] 10171 [C9JH25-3] |
Protocols and materials databases
Antibodypediai | 67265, 69 antibodies |
Genome annotation databases
Ensembli | ENST00000446477; ENSP00000415026; ENSG00000224940 [C9JH25-1] ENST00000489835; ENSP00000419296; ENSG00000224940 [C9JH25-2] ENST00000535159; ENSP00000445239; ENSG00000224940 [C9JH25-1] |
GeneIDi | 401399 |
KEGGi | hsa:401399 |
UCSCi | uc022akx.2, human [C9JH25-1] |
Organism-specific databases
CTDi | 401399 |
GeneCardsi | PRRT4 |
HGNCi | HGNC:37280, PRRT4 |
HPAi | ENSG00000224940, Tissue enriched (bone) |
neXtProti | NX_C9JH25 |
OpenTargetsi | ENSG00000224940 |
PharmGKBi | PA165618245 |
VEuPathDBi | HostDB:ENSG00000224940.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU49, Eukaryota |
GeneTreei | ENSGT00730000111591 |
HOGENOMi | CLU_351937_0_0_1 |
InParanoidi | C9JH25 |
OMAi | CALAEPG |
OrthoDBi | 921831at2759 |
PhylomeDBi | C9JH25 |
Enzyme and pathway databases
PathwayCommonsi | C9JH25 |
Miscellaneous databases
BioGRID-ORCSi | 401399, 12 hits in 874 CRISPR screens |
ChiTaRSi | PRRT4, human |
GenomeRNAii | 401399 |
Pharosi | C9JH25, Tdark |
PROi | PR:C9JH25 |
RNActi | C9JH25, protein |
Gene expression databases
Bgeei | ENSG00000224940, Expressed in bone marrow and 103 other tissues |
ExpressionAtlasi | C9JH25, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR043542, Prrt4-like |
PANTHERi | PTHR35578:SF1, PTHR35578:SF1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRRT4_HUMAN | |
Accessioni | C9JH25Primary (citable) accession number: C9JH25 Secondary accession number(s): A4D0Z9, C9JVW7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 15, 2010 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM