Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 83 (02 Jun 2021)
Sequence version 1 (03 Nov 2009)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Histone-lysine N-methyltransferase SETD2

Gene

SETD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Histone-lysine N-methyltransferase SETD2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SETD2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18420, SETD2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000181555.19

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000181555

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
C9JG86

PeptideAtlas

More...
PeptideAtlasi
C9JG86

PRoteomics IDEntifications database

More...
PRIDEi
C9JG86

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
10074

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000181555, Expressed in oviduct epithelium and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
C9JG86, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 68DisorderedSequence analysisAdd BLAST23
Regioni136 – 167DisorderedSequence analysisAdd BLAST32
Regioni228 – 517DisorderedSequence analysisAdd BLAST290
Regioni563 – 582DisorderedSequence analysisAdd BLAST20
Regioni920 – 951DisorderedSequence analysisAdd BLAST32
Regioni992 – 1056DisorderedSequence analysisAdd BLAST65
Regioni1097 – 1169DisorderedSequence analysisAdd BLAST73
Regioni1260 – 1340DisorderedSequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 62Polar residuesSequence analysisAdd BLAST17
Compositional biasi141 – 157Pro residuesSequence analysisAdd BLAST17
Compositional biasi232 – 253Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi254 – 283Polar residuesSequence analysisAdd BLAST30
Compositional biasi296 – 367Basic and acidic residuesSequence analysisAdd BLAST72
Compositional biasi380 – 427Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi442 – 482Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi500 – 516Polar residuesSequence analysisAdd BLAST17
Compositional biasi923 – 949Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1017 – 1050Polar residuesSequence analysisAdd BLAST34
Compositional biasi1120 – 1135Polar residuesSequence analysisAdd BLAST16
Compositional biasi1322 – 1340Polar residuesSequence analysisAdd BLAST19

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160086

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009078, Ferritin-like_SF
IPR042294, SETD2_animal

The PANTHER Classification System

More...
PANTHERi
PTHR46711, PTHR46711, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47240, SSF47240, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

C9JG86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKGVASSRF LPKGTKTKVN LEEQGRQKVS FSFSLTKKTL QNRFLTALGN
60 70 80 90 100
EKQSDTPNPP AVPLQVDSTP KMKMEIGDTL STAEESSPPK SRVELGKIHF
110 120 130 140 150
KKHLLHVTSR PLLATTTAVA SPPTHAAPLP AVIAESTTVD SPPSSPPPPP
160 170 180 190 200
PPAQATTLSS PAPVTEPVAL PHTPITVLMA APVPLPVDVA VRSLKEPPII
210 220 230 240 250
IVPESLEADT KQDTISNSLE EHVTQILNEQ ADISSKKEDS HIGKDEEIPD
260 270 280 290 300
SSKISLSCKK TGSKKKSSQS EGIFLGSESD EDSVRTSSSQ RSHDLKFSAS
310 320 330 340 350
IEKERDFKKS SAPLKSEDLG KPSRSKTDRD DKYFSYSKLE RDTRYVSSRC
360 370 380 390 400
RSERERRRSR SHSRSERGSR TNLSYSRSER SHYYDSDRRY HRSSPYRERT
410 420 430 440 450
RYSRPYTDNR ARESSDSEEE YKKTYSRRTS SHSSSYRDLR TSSYSKSDRD
460 470 480 490 500
CKTETSYLEM ERRGKYSSKL ERESKRTSEN EAIKRCCSPP NELGFRRGSS
510 520 530 540 550
YSKHDSSASR YKSTLSKPIP KSDKFKNSFC CTELNEEIKQ SHSFSLQTPC
560 570 580 590 600
SKGSELRMIN KNPEREKAGS PAPSNRLNDS PTLKKLDELP IFKSEFITHD
610 620 630 640 650
SHDSIKELDS LSKVKNDQLR SFCPIELNIN GSPGAESDLA TFCTSKTDAV
660 670 680 690 700
LMTSDDSVTG SELSPLVKAC MLSSNGFQNI SRCKEKDLDD TCMLHKKSES
710 720 730 740 750
PFRETEPLVS PHQDKLMSMP VMTVDYSKTV VKEPVDTRVS CCKTKDSDIY
760 770 780 790 800
CTLNDSNPSL CNSEAENIEP SVMKISSNSF MNVHLESKPV ICDSRNLTDH
810 820 830 840 850
SKFACEEYKQ SIGSTSSASV NHFDDLYQPI GSSGIASSLQ SLPPGIKVDS
860 870 880 890 900
LTLLKCGENT SPVLDAVLKS KKSSEFLKHA GKETIVEVGS DLPDSGKGFA
910 920 930 940 950
SRENRRNNGL SGKCLQEAQE EGNSILPERR GRPEISLDER GEGGHVHTSD
960 970 980 990 1000
DSEVVFSSCD LNLTMEDSDG VTYALKCDSS GHAPEIVSTV HEDYSGSSES
1010 1020 1030 1040 1050
SNDESDSEDT DSDDSSIPRN RLQSVVVVPK NSTLPMEETS PCSSRSSQSY
1060 1070 1080 1090 1100
RHYSDHWEDE RLESRRHLYE EKFESIASKA CPQTDKFFLH KGTEKNPEIS
1110 1120 1130 1140 1150
FTQSSRKQID NRLPELSHPQ SDGVDSTSHT DVKSDPLGHP NSEETVKAKI
1160 1170 1180 1190 1200
PSRQQEELPI YSSDFEDVPN KSWQQTTFQN RPDSRLGKTE LSFSSSCEIP
1210 1220 1230 1240 1250
HVDGLHSSEE LRNLGWDFSQ EKPSTTYQQP DSSYGACGGH KYQQNAEQYG
1260 1270 1280 1290 1300
GTRDYWQGNG YWDPRSGRPP GTGVVYDRTQ GQVPDSLTDD REEEENWDQQ
1310 1320 1330 1340
DGSHFSDQSD KFLLSLQKDK GSVQAPEISS NSIKDTLAVN
Length:1,340
Mass (Da):149,254
Last modified:November 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A5EBADB6655ABC2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BYW2SETD2_HUMAN
Histone-lysine N-methyltransferase ...
SETD2 HIF1, HYPB, KIAA1732, KMT3A, SET2
2,564Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3H4H7C3H4_HUMAN
Histone-lysine N-methyltransferase ...
SETD2
1,675Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPX9A0A1W2PPX9_HUMAN
Histone-lysine N-methyltransferase ...
SETD2
591Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ93H7BZ93_HUMAN
Histone-lysine N-methyltransferase ...
SETD2
1,290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXT4H7BXT4_HUMAN
Histone-lysine N-methyltransferase ...
SETD2
1,365Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1340Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC094020 Genomic DNA No translation available.
AC127430 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000412450; ENSP00000416401; ENSG00000181555

UCSC genome browser

More...
UCSCi
uc062jcg.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094020 Genomic DNA No translation available.
AC127430 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiC9JG86
PeptideAtlasiC9JG86
PRIDEiC9JG86
ProteomicsDBi10074

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29842, 333 antibodies

Genome annotation databases

EnsembliENST00000412450; ENSP00000416401; ENSG00000181555
UCSCiuc062jcg.1, human

Organism-specific databases

HGNCiHGNC:18420, SETD2
OpenTargetsiENSG00000181555
VEuPathDBiHostDB:ENSG00000181555.19

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000160086

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SETD2, human

Gene expression databases

BgeeiENSG00000181555, Expressed in oviduct epithelium and 241 other tissues
ExpressionAtlasiC9JG86, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009078, Ferritin-like_SF
IPR042294, SETD2_animal
PANTHERiPTHR46711, PTHR46711, 1 hit
SUPFAMiSSF47240, SSF47240, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC9JG86_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C9JG86
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 2, 2021
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again