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Protein
Submitted name:

Sprouty-related, EVH1 domain-containing protein 2

Gene

SPRED2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Sprouty-related, EVH1 domain-containing protein 2Imported
Gene namesi
Name:SPRED2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000198369.9
HGNCiHGNC:17722 SPRED2

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198369

PTM / Processingi

Proteomic databases

PeptideAtlasiC9JG63
PRIDEiC9JG63

Expressioni

Gene expression databases

BgeeiENSG00000198369 Expressed in 208 organ(s), highest expression level in forebrain
ExpressionAtlasiC9JG63 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9JG63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 137WH1InterPro annotationAdd BLAST118
Domaini216 – 272KBDInterPro annotationAdd BLAST57

Phylogenomic databases

eggNOGiENOG410IQ21 Eukaryota
ENOG410Y62R LUCA
GeneTreeiENSGT00730000110272
HOGENOMiHOG000220886
OMAiDHYHLEQ
OrthoDBiEOG091G0OE8

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337 KBD
IPR011993 PH-like_dom_sf
IPR007875 Sprouty
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488 KBD, 1 hit
PS51227 SPR, 1 hit
PS50229 WH1, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

C9JG63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALCSLISSW ASGFRSDDDQ ERRGDSYIVR VKAVVMTRDD SSGGWFPQEG
60 70 80 90 100
GGISRVGVCK VMHPEGNGRS GFLIHGERQK DKLVVLECYV RKDLVYTKAN
110 120 130 140 150
PTFHHWKVDN RKFGLTFQSP ADARAFDRGV RKAIEDLIEG STTSSSTIHN
160 170 180 190 200
EAELGDDDVF TTATDSSSNS SQKREQPTRT ISSPTSCEHR RIYTLGHLHD
210 220 230 240 250
SYPTDHYHLD QPMPRPYRQV SFPDDDEEIV RINPREKIWM TGYEDYRHAP
260 270 280 290 300
VRGKYPDPSE DADSSYVRFA KGEVPKHDYN YPYVDSSDFG LGEDPKGRGG
310 320 330 340 350
SVIKTQPSRG KSRRRKEDGE RSRCVYCRDM FNHEENRRGH CQDAPDSVRT
360 370 380 390 400
CIRRVSCMWC ADSMLYHCMS DPEGDYTDPC SCDTSDEKFC LRWMALIALS
410 420 430
FLAPCMCCYL PLRACYHCGV MCRCCGGKHK AA
Length:432
Mass (Da):49,101
Last modified:October 5, 2016 - v8
Checksum:iA025BE8D8BB5CCBB
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z698SPRE2_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
418Annotation score:
H7C2T4H7C2T4_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
233Annotation score:
C9J623C9J623_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
116Annotation score:
H7C3Y6H7C3Y6_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
103Annotation score:
H7C065H7C065_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei432Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012370 Genomic DNA No translation available.
AC097503 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000452315; ENSP00000390595; ENSG00000198369
UCSCiuc061juv.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012370 Genomic DNA No translation available.
AC097503 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9JG63
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiC9JG63
PRIDEiC9JG63

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452315; ENSP00000390595; ENSG00000198369
UCSCiuc061juv.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000198369.9
HGNCiHGNC:17722 SPRED2
OpenTargetsiENSG00000198369
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ21 Eukaryota
ENOG410Y62R LUCA
GeneTreeiENSGT00730000110272
HOGENOMiHOG000220886
OMAiDHYHLEQ
OrthoDBiEOG091G0OE8

Miscellaneous databases

ChiTaRSiSPRED2 human

Gene expression databases

BgeeiENSG00000198369 Expressed in 208 organ(s), highest expression level in forebrain
ExpressionAtlasiC9JG63 baseline and differential

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337 KBD
IPR011993 PH-like_dom_sf
IPR007875 Sprouty
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488 KBD, 1 hit
PS51227 SPR, 1 hit
PS50229 WH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JG63_HUMAN
AccessioniPrimary (citable) accession number: C9JG63
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 68 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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