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Protein
Submitted name:

Rho-associated protein kinase 2

Gene

ROCK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

SignaLinkiC9JFJ0

Names & Taxonomyi

Protein namesi
Submitted name:
Rho-associated protein kinase 2Imported
Gene namesi
Name:ROCK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000134318.13
HGNCiHGNC:10252 ROCK2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134318

PTM / Processingi

Proteomic databases

MaxQBiC9JFJ0
PeptideAtlasiC9JFJ0
PRIDEiC9JFJ0

Expressioni

Gene expression databases

BgeeiENSG00000134318 Expressed in 226 organ(s), highest expression level in intestine
ExpressionAtlasiC9JFJ0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9JFJ0
SMRiC9JFJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 181Protein kinaseInterPro annotationAdd BLAST181

Phylogenomic databases

eggNOGiKOG0612 Eukaryota
ENOG410XR1Q LUCA
GeneTreeiENSGT00760000118994
HOGENOMiHOG000233033

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR029875 LET-502
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PANTHERiPTHR22988:SF38 PTHR22988:SF38, 2 hits
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

C9JFJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAEDYDVVK VIGRGAFGEV QLVRHKASQK VYAMKLLSKF EMIKRSDSAF
60 70 80 90 100
FWEERDIMAF ANSPWVVQTG MVHCDTAVGT PDYISPEVLK SQGGDGFYGR
110 120 130 140 150
ECDWWSVGVF LYEMLVGDTP FYADSLVGTY SKIMDHKNSL CFPEDAEISK
160 170 180 190 200
HAKNLICAFL TDREVRLGRN GVEEIRQHPF FKNDQWHWDN IRETAAPVVP

ELS
Length:203
Mass (Da):23,212
Last modified:November 3, 2009 - v1
Checksum:i9CED77CC5BD0E353
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O75116ROCK2_HUMAN
Rho-associated protein kinase 2
ROCK2 KIAA0619
1,388Annotation score:
E9PF63E9PF63_HUMAN
Rho-associated protein kinase 2
ROCK2
1,145Annotation score:
D6REE7D6REE7_HUMAN
Rho-associated protein kinase 2
ROCK2
446Annotation score:
Q14DU5Q14DU5_HUMAN
ROCK2 protein
ROCK2
703Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei203Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018463 Genomic DNA No translation available.
AC099344 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000431087; ENSP00000395957; ENSG00000134318
UCSCiuc061grx.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018463 Genomic DNA No translation available.
AC099344 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9JFJ0
SMRiC9JFJ0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiC9JFJ0
PeptideAtlasiC9JFJ0
PRIDEiC9JFJ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431087; ENSP00000395957; ENSG00000134318
UCSCiuc061grx.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000134318.13
HGNCiHGNC:10252 ROCK2
OpenTargetsiENSG00000134318
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0612 Eukaryota
ENOG410XR1Q LUCA
GeneTreeiENSGT00760000118994
HOGENOMiHOG000233033

Enzyme and pathway databases

SignaLinkiC9JFJ0

Miscellaneous databases

ChiTaRSiROCK2 human

Gene expression databases

BgeeiENSG00000134318 Expressed in 226 organ(s), highest expression level in intestine
ExpressionAtlasiC9JFJ0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR029875 LET-502
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PANTHERiPTHR22988:SF38 PTHR22988:SF38, 2 hits
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JFJ0_HUMAN
AccessioniPrimary (citable) accession number: C9JFJ0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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