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Protein
Submitted name:

Cleavage and polyadenylation-specificity factor subunit 4

Gene

CPSF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 59C3H1-typePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri62 – 89C3H1-typePROSITE-ProRule annotationAdd BLAST28
Zinc fingeri111 – 137C3H1-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Cleavage and polyadenylation-specificity factor subunit 4Imported
Gene namesi
Name:CPSF4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000160917.14
HGNCiHGNC:2327 CPSF4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160917

PTM / Processingi

Proteomic databases

EPDiC9JEV9
MaxQBiC9JEV9
PeptideAtlasiC9JEV9
PRIDEiC9JEV9

Expressioni

Gene expression databases

BgeeiENSG00000160917 Expressed in 223 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiC9JEV9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9JEV9
SMRiC9JEV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 59C3H1-typeInterPro annotationAdd BLAST25
Domaini62 – 89C3H1-typeInterPro annotationAdd BLAST28
Domaini111 – 137C3H1-typeInterPro annotationAdd BLAST27
Domaini187 – 202CCHC-typeInterPro annotationAdd BLAST16

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 59C3H1-typePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri62 – 89C3H1-typePROSITE-ProRule annotationAdd BLAST28
Zinc fingeri111 – 137C3H1-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00390000009627
HOGENOMiHOG000212457

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 2 hits
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SM00356 ZnF_C3H1, 4 hits
SUPFAMiSSF57756 SSF57756, 1 hit
SSF90229 SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 3 hits
PS50158 ZF_CCHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

C9JEV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEIIASVDH IKFDLEIAVE QQLGAQPLPF PGMDKSGAAV CEFFLKAACG
60 70 80 90 100
KGGMCPFRHI SGEKTVVCKH WLRGLCKKGD QCEFLHEYDM TKMPECYFYS
110 120 130 140 150
KFGPLCRHRH TRRVICVNYL VGFCPEGPSC KFMHPRFELP MGTTEQPPLP
160 170 180 190 200
QQTQPPAKRT PQVIGVMQSQ NSSAGNRGPR PLEQVTCYKC GEKGHYANRC
210
TKGHLAFLSG Q
Length:211
Mass (Da):23,653
Last modified:November 3, 2009 - v1
Checksum:iF570725BE19E0E26
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95639CPSF4_HUMAN
Cleavage and polyadenylation specif...
CPSF4 CPSF30, NAR, NEB1
269Annotation score:
H7C419H7C419_HUMAN
Cleavage and polyadenylation-specif...
CPSF4
193Annotation score:
B7Z7B0B7Z7B0_HUMAN
Cleavage and polyadenylation-specif...
CPSF4
191Annotation score:
C9K0K2C9K0K2_HUMAN
Cleavage and polyadenylation-specif...
CPSF4
112Annotation score:
H7C016H7C016_HUMAN
Cleavage and polyadenylation-specif...
CPSF4
229Annotation score:
F8WEL7F8WEL7_HUMAN
Cleavage and polyadenylation-specif...
CPSF4
44Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073063 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000451876; ENSP00000396060; ENSG00000160917
UCSCiuc064ftr.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073063 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9JEV9
SMRiC9JEV9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiC9JEV9
MaxQBiC9JEV9
PeptideAtlasiC9JEV9
PRIDEiC9JEV9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000451876; ENSP00000396060; ENSG00000160917
UCSCiuc064ftr.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000160917.14
HGNCiHGNC:2327 CPSF4
OpenTargetsiENSG00000160917
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009627
HOGENOMiHOG000212457

Gene expression databases

BgeeiENSG00000160917 Expressed in 223 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiC9JEV9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 2 hits
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SM00356 ZnF_C3H1, 4 hits
SUPFAMiSSF57756 SSF57756, 1 hit
SSF90229 SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 3 hits
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9JEV9_HUMAN
AccessioniPrimary (citable) accession number: C9JEV9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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