UniProtKB - C9JE06 (C9JE06_HUMAN)
Protein
Phospholipid scramblase
Gene
PLSCR1
Organism
Homo sapiens (Human)
Status
Functioni
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.UniRule annotation
Cofactori
Ca2+UniRule annotation
GO - Molecular functioni
- phospholipid scramblase activity Source: InterPro
Keywordsi
Ligand | CalciumUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipid scramblaseUniRule annotation |
Gene namesi | Name:PLSCR1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9092, PLSCR1 |
VEuPathDBi | HostDB:ENSG00000188313.12 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
PTM / Processingi
Keywords - PTMi
Lipoprotein, PalmitateUniRule annotationProteomic databases
MaxQBi | C9JE06 |
PeptideAtlasi | C9JE06 |
ProteomicsDBi | 9796 |
PTM databases
SwissPalmi | C9JE06 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188313, Expressed in muscle layer of sigmoid colon and 234 other tissues |
ExpressionAtlasi | C9JE06, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 64 | DisorderedSequence analysisAdd BLAST | 64 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 40 – 64 | Pro-richSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000154435 |
HOGENOMi | CLU_053024_1_1_1 |
Family and domain databases
InterProi | View protein in InterPro IPR005552, Scramblase |
PANTHERi | PTHR23248, PTHR23248, 1 hit |
Pfami | View protein in Pfam PF03803, Scramblase, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
C9JE06-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP
60 70 80 90 100
AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE
110 120 130 140 150
YLSQIDQILI HQQIELLEVL TGFETNNKYE IKNSFGQRVY FAAEDTDCCT
160 170 180 190 200
RNCCGPSRPF TLRIIDNMGQ EVITLERPLR CSSCCCPCCL QEIEIQAPPG
210 220 230 240
VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC GDVDFEIKS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO15162 | PLS1_HUMAN | Phospholipid scramblase 1 | PLSCR1 | 318 | Annotation score: | ||
C9J9P4 | C9J9P4_HUMAN | Phospholipid scramblase | PLSCR1 | 248 | Annotation score: | ||
C9J7K9 | C9J7K9_HUMAN | Phospholipid scramblase | PLSCR1 hCG_17108 | 311 | Annotation score: | ||
H7C5I5 | H7C5I5_HUMAN | Phospholipid scramblase | PLSCR1 | 171 | Annotation score: | ||
C9J0H3 | C9J0H3_HUMAN | Phospholipid scramblase | PLSCR1 | 171 | Annotation score: | ||
F2Z3F2 | F2Z3F2_HUMAN | Phospholipid scramblase 1 | PLSCR1 | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 249 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC069528 Genomic DNA No translation available. AC116544 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000472349; ENSP00000420523; ENSG00000188313 |
UCSCi | uc062oth.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC069528 Genomic DNA No translation available. AC116544 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | C9JE06 |
Proteomic databases
MaxQBi | C9JE06 |
PeptideAtlasi | C9JE06 |
ProteomicsDBi | 9796 |
Protocols and materials databases
Antibodypediai | 18144, 255 antibodies |
Genome annotation databases
Ensembli | ENST00000472349; ENSP00000420523; ENSG00000188313 |
UCSCi | uc062oth.1, human |
Organism-specific databases
HGNCi | HGNC:9092, PLSCR1 |
OpenTargetsi | ENSG00000188313 |
VEuPathDBi | HostDB:ENSG00000188313.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154435 |
HOGENOMi | CLU_053024_1_1_1 |
Miscellaneous databases
ChiTaRSi | PLSCR1, human |
Gene expression databases
Bgeei | ENSG00000188313, Expressed in muscle layer of sigmoid colon and 234 other tissues |
ExpressionAtlasi | C9JE06, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR005552, Scramblase |
PANTHERi | PTHR23248, PTHR23248, 1 hit |
Pfami | View protein in Pfam PF03803, Scramblase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C9JE06_HUMAN | |
Accessioni | C9JE06Primary (citable) accession number: C9JE06 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |