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Protein

Putative claudin-25

Gene

CLDN25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Putative claudin-25
Gene namesi
Name:CLDN25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000228607.2
HGNCiHGNC:37218 CLDN25
neXtProtiNX_C9JDP6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 81ExtracellularSequence analysisAdd BLAST50
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 124CytoplasmicSequence analysisAdd BLAST22
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 164ExtracellularSequence analysisAdd BLAST19
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 229CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000228607
PharmGKBiPA165543379

Polymorphism and mutation databases

BioMutaiCLDN25

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003954031 – 229Putative claudin-25Add BLAST229

Proteomic databases

PaxDbiC9JDP6
PRIDEiC9JDP6
ProteomicsDBi9751

Expressioni

Gene expression databases

BgeeiENSG00000228607 Expressed in 6 organ(s), highest expression level in pituitary gland

Organism-specific databases

HPAiHPA053555

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396304

Structurei

3D structure databases

ProteinModelPortaliC9JDP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INS5 Eukaryota
ENOG4111QE3 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
InParanoidiC9JDP6
KOiK06087
OMAiLPQWKTL
OrthoDBiEOG091G0QQ0
PhylomeDBiC9JDP6
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit

Sequencei

Sequence statusi: Complete.

C9JDP6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWSFRAKVQ LGGLLLSLLG WVCSCVTTIL PQWKTLNLEL NEMETWIMGI
60 70 80 90 100
WEVCVDREEV ATVCKAFESF LSLPQELQVA RILMVASHGL GLLGLLLCSF
110 120 130 140 150
GSECFQFHRI RWVFKRRLGL LGRTLEASAS ATTLLPVSWV AHATIQDFWD
160 170 180 190 200
DSIPDIIPRW EFGGALYLGW AAGIFLALGG LLLIFSACLG KEDVPFPLMA
210 220
GPTVPLSCAP VEESDGSFHL MLRPRNLVI
Length:229
Mass (Da):25,394
Last modified:November 3, 2009 - v1
Checksum:i86EC6AEE87BCA151
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063401219H → Y. Corresponds to variant dbSNP:rs35111413Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003170 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67230.1
CCDSiCCDS44736.1
RefSeqiNP_001094859.1, NM_001101389.1
UniGeneiHs.705360

Genome annotation databases

EnsembliENST00000453129; ENSP00000396304; ENSG00000228607
GeneIDi644672
KEGGihsa:644672
UCSCiuc009yyw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003170 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67230.1
CCDSiCCDS44736.1
RefSeqiNP_001094859.1, NM_001101389.1
UniGeneiHs.705360

3D structure databases

ProteinModelPortaliC9JDP6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000396304

Polymorphism and mutation databases

BioMutaiCLDN25

Proteomic databases

PaxDbiC9JDP6
PRIDEiC9JDP6
ProteomicsDBi9751

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000453129; ENSP00000396304; ENSG00000228607
GeneIDi644672
KEGGihsa:644672
UCSCiuc009yyw.2 human

Organism-specific databases

CTDi644672
EuPathDBiHostDB:ENSG00000228607.2
GeneCardsiCLDN25
HGNCiHGNC:37218 CLDN25
HPAiHPA053555
neXtProtiNX_C9JDP6
OpenTargetsiENSG00000228607
PharmGKBiPA165543379
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INS5 Eukaryota
ENOG4111QE3 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
InParanoidiC9JDP6
KOiK06087
OMAiLPQWKTL
OrthoDBiEOG091G0QQ0
PhylomeDBiC9JDP6
TreeFamiTF331936

Miscellaneous databases

GenomeRNAii644672

Gene expression databases

BgeeiENSG00000228607 Expressed in 6 organ(s), highest expression level in pituitary gland

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD25_HUMAN
AccessioniPrimary (citable) accession number: C9JDP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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