UniProtKB - C9JCN9 (HSBPL_HUMAN)
Protein
Heat shock factor-binding protein 1-like protein 1
Gene
HSBP1L1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- transcription corepressor activity Source: InterPro
GO - Biological processi
- cellular heat acclimation Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock factor-binding protein 1-like protein 1 |
Gene namesi | Name:HSBP1L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000226742.3 |
HGNCi | HGNC:37243 HSBP1L1 |
neXtProti | NX_C9JCN9 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000226742 |
PharmGKBi | PA165429036 |
Polymorphism and mutation databases
BioMutai | HSBP1L1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000394662 | 1 – 74 | Heat shock factor-binding protein 1-like protein 1Add BLAST | 74 |
Proteomic databases
PaxDbi | C9JCN9 |
PRIDEi | C9JCN9 |
ProteomicsDBi | 9622 |
TopDownProteomicsi | C9JCN9 |
PTM databases
iPTMneti | C9JCN9 |
PhosphoSitePlusi | C9JCN9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000226742 Expressed in 164 organ(s), highest expression level in right lobe of liver |
ExpressionAtlasi | C9JCN9 baseline and differential |
Genevisiblei | C9JCN9 HS |
Organism-specific databases
HPAi | HPA048273 |
Interactioni
Protein-protein interaction databases
BioGridi | 136630, 1 interactor |
IntActi | C9JCN9, 10 interactors |
Structurei
3D structure databases
ProteinModelPortali | C9JCN9 |
SMRi | C9JCN9 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 12 – 65 | Sequence analysisAdd BLAST | 54 |
Sequence similaritiesi
Belongs to the HSBP1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG410JH4K Eukaryota ENOG4111AKH LUCA |
GeneTreei | ENSGT00550000076117 |
HOGENOMi | HOG000217518 |
HOVERGENi | HBG101197 |
InParanoidi | C9JCN9 |
OMAi | MDARGPE |
OrthoDBi | 1576489at2759 |
PhylomeDBi | C9JCN9 |
Family and domain databases
InterProi | View protein in InterPro IPR009643 HS1-bd |
PANTHERi | PTHR19424 PTHR19424, 1 hit |
Pfami | View protein in Pfam PF06825 HSBP1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
C9JCN9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVRGPEAPG GRALRDAAEN LFQELQEHFQ ALTATLNLRM EEMGNRIEDL
60 70
QKNVKDLMVQ AGIENSIKEQ MLKT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7ENV5 | K7ENV5_HUMAN | Heat shock factor-binding protein 1... | HSBP1L1 | 45 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | K → N in AAI57849 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090360 Genomic DNA No translation available. AC114341 Genomic DNA No translation available. CH471117 Genomic DNA Translation: EAW66638.1 BC157848 mRNA Translation: AAI57849.1 |
CCDSi | CCDS45886.1 |
RefSeqi | NP_001129652.1, NM_001136180.1 |
UniGenei | Hs.191582 |
Genome annotation databases
Ensembli | ENST00000451882; ENSP00000414236; ENSG00000226742 |
GeneIDi | 440498 |
KEGGi | hsa:440498 |
UCSCi | uc002lno.5 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090360 Genomic DNA No translation available. AC114341 Genomic DNA No translation available. CH471117 Genomic DNA Translation: EAW66638.1 BC157848 mRNA Translation: AAI57849.1 |
CCDSi | CCDS45886.1 |
RefSeqi | NP_001129652.1, NM_001136180.1 |
UniGenei | Hs.191582 |
3D structure databases
ProteinModelPortali | C9JCN9 |
SMRi | C9JCN9 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 136630, 1 interactor |
IntActi | C9JCN9, 10 interactors |
PTM databases
iPTMneti | C9JCN9 |
PhosphoSitePlusi | C9JCN9 |
Polymorphism and mutation databases
BioMutai | HSBP1L1 |
Proteomic databases
PaxDbi | C9JCN9 |
PRIDEi | C9JCN9 |
ProteomicsDBi | 9622 |
TopDownProteomicsi | C9JCN9 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000451882; ENSP00000414236; ENSG00000226742 |
GeneIDi | 440498 |
KEGGi | hsa:440498 |
UCSCi | uc002lno.5 human |
Organism-specific databases
CTDi | 440498 |
EuPathDBi | HostDB:ENSG00000226742.3 |
GeneCardsi | HSBP1L1 |
HGNCi | HGNC:37243 HSBP1L1 |
HPAi | HPA048273 |
neXtProti | NX_C9JCN9 |
OpenTargetsi | ENSG00000226742 |
PharmGKBi | PA165429036 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410JH4K Eukaryota ENOG4111AKH LUCA |
GeneTreei | ENSGT00550000076117 |
HOGENOMi | HOG000217518 |
HOVERGENi | HBG101197 |
InParanoidi | C9JCN9 |
OMAi | MDARGPE |
OrthoDBi | 1576489at2759 |
PhylomeDBi | C9JCN9 |
Miscellaneous databases
GenomeRNAii | 440498 |
PROi | PR:C9JCN9 |
Gene expression databases
Bgeei | ENSG00000226742 Expressed in 164 organ(s), highest expression level in right lobe of liver |
ExpressionAtlasi | C9JCN9 baseline and differential |
Genevisiblei | C9JCN9 HS |
Family and domain databases
InterProi | View protein in InterPro IPR009643 HS1-bd |
PANTHERi | PTHR19424 PTHR19424, 1 hit |
Pfami | View protein in Pfam PF06825 HSBP1, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | HSBPL_HUMAN | |
Accessioni | C9JCN9Primary (citable) accession number: C9JCN9 Secondary accession number(s): B2RXG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 15, 2010 |
Last sequence update: | June 15, 2010 | |
Last modified: | February 13, 2019 | |
This is version 60 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM