UniProtKB - C9JC84 (C9JC84_HUMAN)
Protein
Submitted name:
Fibrinogen gamma chain
Gene
FGG
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- signaling receptor binding Source: InterPro
GO - Biological processi
- cellular response to interleukin-1 Source: Ensembl
- cellular response to interleukin-6 Source: Ensembl
- negative regulation of platelet aggregation Source: Ensembl
- platelet activation Source: InterPro
- platelet maturation Source: Ensembl
- protein polymerization Source: InterPro
Keywordsi
Biological process | Blood coagulationARBA annotation, Hemostasis |
Ligand | CalciumARBA annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Fibrinogen gamma chainImported |
Gene namesi | Name:FGGImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3694, FGG |
VEuPathDBi | HostDB:ENSG00000171557.16 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- blood microparticle Source: Ensembl
- fibrinogen complex Source: InterPro
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5002997176 | 27 – 461 | Sequence analysisAdd BLAST | 435 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
MaxQBi | C9JC84 |
PeptideAtlasi | C9JC84 |
PRIDEi | C9JC84 |
ProteomicsDBi | 9561 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171557, Expressed in liver and 118 other tissues |
ExpressionAtlasi | C9JC84, baseline and differential |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- signaling receptor binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 178 – 424 | Fibrinogen C-terminalInterPro annotationAdd BLAST | 247 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 432 – 461 | DisorderedSequence analysisAdd BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 66 – 89 | Sequence analysisAdd BLAST | 24 | |
Coiled coili | 140 – 160 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 439 – 453 | PolyampholyteSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotation, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000158467 |
OMAi | MNRCHAG |
PhylomeDBi | C9JC84 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit 4.10.530.10, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR014715, Fibrinogen_a/b/g_C_2 IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR020837, Fibrinogen_CS IPR037581, Fibrinogen_gamma |
PANTHERi | PTHR19143:SF338, PTHR19143:SF338, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
C9JC84-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSWSLHPRNL ILYFYALLFL SSTCVAYVAT RDNCCILDER FGSYCPTTCG
60 70 80 90 100
IADFLSTYQT KVDKDLQSLE DILHQVENKT SEVKQLIKAI QLTYNPDESS
110 120 130 140 150
KPNMIDAATL KSRKMLEEIM KYEASILTHD SSIRYLQEIY NSNNQKIVNL
160 170 180 190 200
KEKVAQLEAQ CQEPCKDTVQ IHDITGKVKV DSPSLDCQDI ANKGAKQSGL
210 220 230 240 250
YFIKPLKANQ QFLVYCEIDG SGNGWTVFQK RLDGSVDFKK NWIQYKEGFG
260 270 280 290 300
HLSPTGTTEF WLGNEKIHLI STQSAIPYAL RVELEDWNGR TSTADYAMFK
310 320 330 340 350
VGPEADKYRL TYAYFAGGDA GDAFDGFDFG DDPSDKFFTS HNGMQFSTWD
360 370 380 390 400
NDNDKFEGNC AEQDGSGWWM NKCHAGHLNG VYYQGGTYSK ASTPNGYDNG
410 420 430 440 450
IIWATWKTRW YSMKKTTMKI IPFNRLTIGE GQQHHLGGAK QVRPEHPAET
460
EYDSLYPEDD L
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP02679 | FIBG_HUMAN | Fibrinogen gamma chain | FGG PRO2061 | 453 | Annotation score: | ||
C9JEU5 | C9JEU5_HUMAN | Fibrinogen gamma chain | FGG | 445 | Annotation score: | ||
C9JU00 | C9JU00_HUMAN | Fibrinogen gamma chain | FGG | 123 | Annotation score: | ||
C9JPQ9 | C9JPQ9_HUMAN | Fibrinogen gamma chain | FGG | 119 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC107385 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000407946; ENSP00000384552; ENSG00000171557 |
UCSCi | uc063ajy.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC107385 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | C9JC84 |
PeptideAtlasi | C9JC84 |
PRIDEi | C9JC84 |
ProteomicsDBi | 9561 |
Protocols and materials databases
Antibodypediai | 16774, 636 antibodies |
Genome annotation databases
Ensembli | ENST00000407946; ENSP00000384552; ENSG00000171557 |
UCSCi | uc063ajy.1, human |
Organism-specific databases
HGNCi | HGNC:3694, FGG |
OpenTargetsi | ENSG00000171557 |
VEuPathDBi | HostDB:ENSG00000171557.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158467 |
OMAi | MNRCHAG |
PhylomeDBi | C9JC84 |
Miscellaneous databases
ChiTaRSi | FGG, human |
Gene expression databases
Bgeei | ENSG00000171557, Expressed in liver and 118 other tissues |
ExpressionAtlasi | C9JC84, baseline and differential |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit 4.10.530.10, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR014715, Fibrinogen_a/b/g_C_2 IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR020837, Fibrinogen_CS IPR037581, Fibrinogen_gamma |
PANTHERi | PTHR19143:SF338, PTHR19143:SF338, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C9JC84_HUMAN | |
Accessioni | C9JC84Primary (citable) accession number: C9JC84 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |