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Entry version 90 (07 Oct 2020)
Sequence version 2 (05 Apr 2011)
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Protein
Submitted name:

SID1 transmembrane family member 2

Gene

SIDT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SID1 transmembrane family member 2Imported
Submitted name:
SID1 transmembrane family, member 2, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIDT2Imported
ORF Names:hCG_2039721Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149577.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24272, SIDT2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei292 – 317HelicalSequence analysisAdd BLAST26
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Transmembranei524 – 542HelicalSequence analysisAdd BLAST19
Transmembranei570 – 591HelicalSequence analysisAdd BLAST22
Transmembranei628 – 647HelicalSequence analysisAdd BLAST20
Transmembranei653 – 675HelicalSequence analysisAdd BLAST23
Transmembranei710 – 729HelicalSequence analysisAdd BLAST20
Transmembranei735 – 756HelicalSequence analysisAdd BLAST22
Transmembranei768 – 788HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000149577

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501408687819 – 855Sequence analysisAdd BLAST837

Keywords - PTMi

GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
C9JBG5

PRoteomics IDEntifications database

More...
PRIDEi
C9JBG5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
9462

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149577, Expressed in endothelial cell and 237 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SID1 family.ARBA annotation

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010091

Identification of Orthologs from Complete Genome Data

More...
OMAi
GLHQTMT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025958, SID1_TM_fam

The PANTHER Classification System

More...
PANTHERi
PTHR12185, PTHR12185, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13965, SID-1_RNA_chan, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

C9JBG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFALGLPFLV LLVASVESHL GVLGPKNVSQ KDAEFERTYV DEVNSELVNI
60 70 80 90 100
YTFNHTVTRN RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR
110 120 130 140 150
GMFQRKYLYQ KVERTLCQPP TKNESEIQFF YVDVSTLSPV NTTYQLRVSR
160 170 180 190 200
MDDFVLRTGE QFSFNTTAAQ PQYFKYEFPE GVDSVIVKVT SNKAFPCSVI
210 220 230 240 250
SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS NSFYVVVVVK
260 270 280 290 300
TEDQACGGSL PFYPFAEDEP VDQGHRQKTL SVLVSQAVTS EAYVSGMLFC
310 320 330 340 350
LGIFLSFYLL TVLLACWENW RQKKKTLLVA IDRACPESGH PRVLADSFPG
360 370 380 390 400
SSPYEGYNYG SFENVSGSTD GLVDSAGTGD LSYGYQGHDQ FKRRLPSGQM
410 420 430 440 450
RQLCIAMGRS FEPVGTRPRV DSMSSVEEDD YDTLTDIDSD KNVIRTKQYL
460 470 480 490 500
YVADLARKDK RVLRKKYQIY FWNIATIAVF YALPVVQLVI TYQTVVNVTG
510 520 530 540 550
NQDICYYNFL CAHPLGNLSA FNNILSNLGY ILLGLLFLLI ILQREINHNR
560 570 580 590 600
ALLRNDLCAL ECGIPKHFGL FYAMGTALMM EGLLSACYHV CPNYTNFQFD
610 620 630 640 650
TSFMYMIAGL CMLKLYQKRH PDINASAYSA YACLAIVIFF SVLGVVFGKG
660 670 680 690 700
NTAFWIVFSI IHIIATLLLS TQLYYMGRWK LDSGIFRRIL HVLYTDCIRQ
710 720 730 740 750
CSGPLYVDRM VLLVMGNVIN WSLAAYGLIM RPNDFASYLL AIGICNLLLY
760 770 780 790 800
FAFYIIMKLR SGERIKLIPL LCIVCTSVVW GFALFFFFQG LSTWQKTPAE
810 820 830 840 850
SREHNRDCIL LDFFDDHDIW HFLSSIAMFG SFLVSGPPGR AGWVREGSSC

LLLCG
Length:855
Mass (Da):96,729
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D1EDAD826ABEF61
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NBJ9SIDT2_HUMAN
SID1 transmembrane family member 2
SIDT2 CGI-40, PSEC0072, UNQ685/PRO1325
832Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H8L4F5H8L4_HUMAN
SID1 transmembrane family member 2
SIDT2
829Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMC3E9PMC3_HUMAN
SID1 transmembrane family member 2
SIDT2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPN9E9PPN9_HUMAN
SID1 transmembrane family member 2
SIDT2
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEI3H0YEI3_HUMAN
SID1 transmembrane family member 2
SIDT2
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V172G3V172_HUMAN
SID1 transmembrane family member 2
SIDT2 hCG_2039721
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PME7E9PME7_HUMAN
SID1 transmembrane family member 2
SIDT2
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP005018 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67283.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278951; ENSP00000278951; ENSG00000149577
ENST00000628876; ENSP00000486114; ENSG00000149577

UCSC genome browser

More...
UCSCi
uc001pqg.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005018 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67283.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiC9JBG5
PRIDEiC9JBG5
ProteomicsDBi9462

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32315, 97 antibodies

Genome annotation databases

EnsembliENST00000278951; ENSP00000278951; ENSG00000149577
ENST00000628876; ENSP00000486114; ENSG00000149577
UCSCiuc001pqg.3, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000149577.15
HGNCiHGNC:24272, SIDT2
OpenTargetsiENSG00000149577

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000010091
OMAiGLHQTMT

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SIDT2, human

Gene expression databases

BgeeiENSG00000149577, Expressed in endothelial cell and 237 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR025958, SID1_TM_fam
PANTHERiPTHR12185, PTHR12185, 1 hit
PfamiView protein in Pfam
PF13965, SID-1_RNA_chan, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC9JBG5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C9JBG5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: April 5, 2011
Last modified: October 7, 2020
This is version 90 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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