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Protein
Submitted name:

Ras guanyl-releasing protein 3

Gene

RASGRP3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ras guanyl-releasing protein 3Imported
Gene namesi
Name:RASGRP3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000152689.17
HGNCiHGNC:14545 RASGRP3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152689

PTM / Processingi

Proteomic databases

PRIDEiC9J9C9

Expressioni

Gene expression databases

BgeeiENSG00000152689 Expressed in 209 organ(s), highest expression level in corpus callosum
ExpressionAtlasiC9J9C9 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliC9J9C9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 77N-terminal Ras-GEFInterPro annotationAdd BLAST75

Phylogenomic databases

eggNOGiENOG410IQ6M Eukaryota
ENOG410XTGZ LUCA
GeneTreeiENSGT00880000137870

Family and domain databases

InterProiView protein in InterPro
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113 PTHR23113, 1 hit
PTHR23113:SF178 PTHR23113:SF178, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50212 RASGEF_NTER, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

C9J9C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSSGLGKAA TLDELLCTCI EMFDDNGELD NSYLPRIVLL MHRWYLSSTE
60 70
LAEKLLCMYR NATGESCNEF RLKICYF
Length:77
Mass (Da):8,809
Last modified:November 3, 2009 - v1
Checksum:iFA0132A215508D23
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IV61GRP3_HUMAN
Ras guanyl-releasing protein 3
RASGRP3 GRP3, KIAA0846
690Annotation score:
C9K0P4C9K0P4_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
172Annotation score:
C9JWP0C9JWP0_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
113Annotation score:
C9IYA5C9IYA5_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
112Annotation score:
H7C352H7C352_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
138Annotation score:
C9JSS2C9JSS2_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
34Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei77Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020594 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000442390; ENSP00000405648; ENSG00000152689
UCSCiuc061hzl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020594 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9J9C9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiC9J9C9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442390; ENSP00000405648; ENSG00000152689
UCSCiuc061hzl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000152689.17
HGNCiHGNC:14545 RASGRP3
OpenTargetsiENSG00000152689
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ6M Eukaryota
ENOG410XTGZ LUCA
GeneTreeiENSGT00880000137870

Miscellaneous databases

ChiTaRSiRASGRP3 human

Gene expression databases

BgeeiENSG00000152689 Expressed in 209 organ(s), highest expression level in corpus callosum
ExpressionAtlasiC9J9C9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113 PTHR23113, 1 hit
PTHR23113:SF178 PTHR23113:SF178, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50212 RASGEF_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9J9C9_HUMAN
AccessioniPrimary (citable) accession number: C9J9C9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 7, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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