UniProtKB - C9J8Q5 (C9J8Q5_HUMAN)
Protein
Succinate-semialdehyde dehydrogenase
Gene
ALDH5A1
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).ARBA annotation
Catalytic activityi
- EC:1.2.1.24UniRule annotationARBA annotation
: 4-aminobutanoate degradation Pathwayi
This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 278 | PROSITE-ProRule annotation | 1 | |
Active sitei | 312 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- succinate-semialdehyde dehydrogenase (NAD+) activity Source: UniProtKB-UniRule
GO - Biological processi
- gamma-aminobutyric acid catabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | NADUniRule annotation |
Enzyme and pathway databases
UniPathwayi | UPA00733 |
Names & Taxonomyi
Protein namesi | Recommended name: Succinate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.24UniRule annotation) |
Gene namesi | Name:ALDH5A1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:408, ALDH5A1 |
VEuPathDBi | HostDB:ENSG00000112294.12 |
Subcellular locationi
Mitochondrion
- Mitochondrion UniRule annotationARBA annotation
Mitochondrion
- mitochondrion Source: HPA
Keywords - Cellular componenti
MitochondrionUniRule annotationPTM / Processingi
Proteomic databases
MaxQBi | C9J8Q5 |
PeptideAtlasi | C9J8Q5 |
PRIDEi | C9J8Q5 |
ProteomicsDBi | 9083 |
PTM databases
SwissPalmi | C9J8Q5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000112294, Expressed in vastus lateralis and 231 other tissues |
ExpressionAtlasi | C9J8Q5, baseline and differential |
Interactioni
Subunit structurei
Homotetramer.
UniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 116 – 502 | AldedhInterPro annotationAdd BLAST | 387 |
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00930000151038 |
HOGENOMi | CLU_005391_1_0_1 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 2 hits |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010102, Succ_semiAld_DH |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01780, SSADH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
C9J8Q5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGR
60 70 80 90 100
LAGLSAALLR TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA
110 120 130 140 150
AVRAAYEAFC RWREVSAKGK PLKEAHGEIL YSAFFLEWFS EEARRVYGDI
160 170 180 190 200
IHTPAKDRRA LVLKQPIGVA AVITPWNFPS AMITRKVGAA LAAGCTVVVK
210 220 230 240 250
PAEDTPFSAL ALAELASQAG IPSGVYNVIP CSRKNAKEVG EAICTDPLVS
260 270 280 290 300
KISFTGSTTT GKILLHHAAN SVKRVSMELG GLAPFIVFDS ANVDQAVAGA
310 320 330 340 350
MASKFRNTGQ TCVCSNQFLV QRGIHDAFVK AFAEAMKKNL RVGNGFEEGT
360 370 380 390 400
TQGPLINEKA VEKVEKQVND AVSKGATVVT GGKRHQLGKN FFEPTLLCNV
410 420 430 440 450
TQDMLCTHEE TFGPLAPVIK FDTEEEAIAI ANAADVGLAG YFYSQDPAQI
460 470 480 490 500
WRVAEQLEVG MVGVNEGLIS SVECPFGGVK QSGLGREGSK YGIDEYLELK
YVCYGGL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP51649 | SSDH_HUMAN | Succinate-semialdehyde dehydrogenas... | ALDH5A1 SSADH | 535 | Annotation score: | ||
A0A5F9ZI23 | A0A5F9ZI23_HUMAN | Succinate-semialdehyde dehydrogenas... | ALDH5A1 | 408 | Annotation score: | ||
A0A5F9ZH05 | A0A5F9ZH05_HUMAN | Succinate-semialdehyde dehydrogenas... | ALDH5A1 | 99 | Annotation score: | ||
A0A5F9ZH98 | A0A5F9ZH98_HUMAN | Succinate-semialdehyde dehydrogenas... | ALDH5A1 | 229 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031230 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000491546; ENSP00000417687; ENSG00000112294 |
UCSCi | uc063mdx.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031230 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | C9J8Q5 |
Proteomic databases
MaxQBi | C9J8Q5 |
PeptideAtlasi | C9J8Q5 |
PRIDEi | C9J8Q5 |
ProteomicsDBi | 9083 |
Protocols and materials databases
Antibodypediai | 25307, 432 antibodies |
Genome annotation databases
Ensembli | ENST00000491546; ENSP00000417687; ENSG00000112294 |
UCSCi | uc063mdx.1, human |
Organism-specific databases
HGNCi | HGNC:408, ALDH5A1 |
OpenTargetsi | ENSG00000112294 |
VEuPathDBi | HostDB:ENSG00000112294.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00930000151038 |
HOGENOMi | CLU_005391_1_0_1 |
Enzyme and pathway databases
UniPathwayi | UPA00733 |
Miscellaneous databases
ChiTaRSi | ALDH5A1, human |
Gene expression databases
Bgeei | ENSG00000112294, Expressed in vastus lateralis and 231 other tissues |
ExpressionAtlasi | C9J8Q5, baseline and differential |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 2 hits |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010102, Succ_semiAld_DH |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01780, SSADH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C9J8Q5_HUMAN | |
Accessioni | C9J8Q5Primary (citable) accession number: C9J8Q5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |