UniProtKB - C9J7K9 (C9J7K9_HUMAN)
Protein
Phospholipid scramblase
Gene
PLSCR1
Organism
Homo sapiens (Human)
Status
Functioni
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.UniRule annotation
Cofactori
Ca2+UniRule annotation
GO - Molecular functioni
- phospholipid scramblase activity Source: InterPro
Keywordsi
Ligand | CalciumUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipid scramblaseUniRule annotation |
Gene namesi | Name:PLSCR1Imported ORF Names:hCG_17108Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9092, PLSCR1 |
VEuPathDBi | HostDB:ENSG00000188313.12 |
PTM / Processingi
Keywords - PTMi
Lipoprotein, PalmitateUniRule annotationProteomic databases
MaxQBi | C9J7K9 |
PRIDEi | C9J7K9 |
ProteomicsDBi | 8917 |
PTM databases
SwissPalmi | C9J7K9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188313, Expressed in muscle layer of sigmoid colon and 234 other tissues |
ExpressionAtlasi | C9J7K9, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 56 | Pro-richSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000154435 |
HOGENOMi | CLU_053024_2_0_1 |
OrthoDBi | 1015148at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR005552, Scramblase |
PANTHERi | PTHR23248, PTHR23248, 1 hit |
Pfami | View protein in Pfam PF03803, Scramblase, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
C9J7K9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNASHPETNL PVGYPPQYPP TAFQGPPGYS GYPGPQVSYP PPPAGHSGPG
60 70 80 90 100
PAGFPVPNQP VYNQPVYNQP VGAAGVPWMP APQPPLNCPP GLEYLSQIDQ
110 120 130 140 150
ILIHQQIELL EVLTGFETNN KYEIKNSFGQ RVYFAAEDTD CCTRNCCGPS
160 170 180 190 200
RPFTLRIIDN MGQEVITLER PLRCSSCCCP CCLQEIEIQA PPGVPIGYVI
210 220 230 240 250
QTWHPCLPKF TIQNEKREDV LKISGPCVVC SCCGDVDFEI KSLDEQCVVG
260 270 280 290 300
KISKHWTGIL REAFTDADNF GIQFPLDLDV KMKAVMIGAC FLIDFMFFES
310
TGSQEQKSGV W
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO15162 | PLS1_HUMAN | Phospholipid scramblase 1 | PLSCR1 | 318 | Annotation score: | ||
C9J9P4 | C9J9P4_HUMAN | Phospholipid scramblase | PLSCR1 | 248 | Annotation score: | ||
C9JE06 | C9JE06_HUMAN | Phospholipid scramblase | PLSCR1 | 249 | Annotation score: | ||
H7C5I5 | H7C5I5_HUMAN | Phospholipid scramblase | PLSCR1 | 171 | Annotation score: | ||
C9J0H3 | C9J0H3_HUMAN | Phospholipid scramblase | PLSCR1 | 171 | Annotation score: | ||
F2Z3F2 | F2Z3F2_HUMAN | Phospholipid scramblase 1 | PLSCR1 | 41 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC069528 Genomic DNA No translation available. AC116544 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78929.1 |
RefSeqi | XP_011511207.1, XM_011512905.1 |
Genome annotation databases
Ensembli | ENST00000487389; ENSP00000417792; ENSG00000188313 |
UCSCi | uc062osx.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC069528 Genomic DNA No translation available. AC116544 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78929.1 |
RefSeqi | XP_011511207.1, XM_011512905.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | C9J7K9 |
Proteomic databases
MaxQBi | C9J7K9 |
PRIDEi | C9J7K9 |
ProteomicsDBi | 8917 |
Protocols and materials databases
Antibodypediai | 18144, 255 antibodies |
Genome annotation databases
Ensembli | ENST00000487389; ENSP00000417792; ENSG00000188313 |
UCSCi | uc062osx.1, human |
Organism-specific databases
HGNCi | HGNC:9092, PLSCR1 |
OpenTargetsi | ENSG00000188313 |
VEuPathDBi | HostDB:ENSG00000188313.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154435 |
HOGENOMi | CLU_053024_2_0_1 |
OrthoDBi | 1015148at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5359, 6 hits in 879 CRISPR screens |
ChiTaRSi | PLSCR1, human |
GenomeRNAii | 5359 |
Gene expression databases
Bgeei | ENSG00000188313, Expressed in muscle layer of sigmoid colon and 234 other tissues |
ExpressionAtlasi | C9J7K9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR005552, Scramblase |
PANTHERi | PTHR23248, PTHR23248, 1 hit |
Pfami | View protein in Pfam PF03803, Scramblase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C9J7K9_HUMAN | |
Accessioni | C9J7K9Primary (citable) accession number: C9J7K9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |