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Protein

Phospholipid scramblase

Gene

PLSCR4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.UniRule annotation

Cofactori

Ca2+UniRule annotation

Keywordsi

LigandCalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblaseUniRule annotation
Gene namesi
Name:PLSCR4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114698.14
HGNCiHGNC:16497 PLSCR4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114698

PTM / Processingi

Keywords - PTMi

Lipoprotein, PalmitateUniRule annotation

Proteomic databases

PeptideAtlasiC9J6E1
PRIDEiC9J6E1

Expressioni

Gene expression databases

BgeeiENSG00000114698 Expressed in 221 organ(s), highest expression level in germinal epithelium of ovary
ExpressionAtlasiC9J6E1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9J6E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipid scramblase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0621 Eukaryota
ENOG410XSYS LUCA
GeneTreeiENSGT00390000002884
HOGENOMiHOG000237356

Family and domain databases

InterProiView protein in InterPro
IPR005552 Scramblase
PANTHERiPTHR23248 PTHR23248, 1 hit
PfamiView protein in Pfam
PF03803 Scramblase, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

C9J6E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGVVPTAPE QPAGEMENQT KPPDPRPDAP PEYNSHFLPG PPGTAVPPPT
60 70 80 90 100
GYPGGLPMGY YSPQQPSTFP LYQPVGGIHP VRYQPGKYPM PNQSVPITWM
110 120 130 140 150
PGPTPMANCP PGLEYLVQLD NIHVLQHFEP LEMMTCFETN NRYDIKNNSD
160 170 180 190 200
QMVYIVTEDT DDFTRNAYRT LRPFVLRVTD CMGREIMTMQ RPFRCTCCCF
210 220 230 240 250
CCPSARQELE VQCPPGVTIG FVAEHWNLCR AVYSIQNEKK ENVMRVRGPC
260
STYGCGSDSV FE
Length:262
Mass (Da):29,376
Last modified:November 3, 2009 - v1
Checksum:iD9DF1117DD3839EA
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NRQ2PLS4_HUMAN
Phospholipid scramblase 4
PLSCR4 GIG43
329Annotation score:
E9PHR9E9PHR9_HUMAN
Phospholipid scramblase
PLSCR4
239Annotation score:
C9JNW2C9JNW2_HUMAN
Phospholipid scramblase
PLSCR4
147Annotation score:
C9J664C9J664_HUMAN
Phospholipid scramblase
PLSCR4
142Annotation score:
C9J916C9J916_HUMAN
Phospholipid scramblase
PLSCR4
208Annotation score:
C9J3P9C9J3P9_HUMAN
Phospholipid scramblase 4
PLSCR4
97Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei262Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092982 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000460350; ENSP00000417896; ENSG00000114698
UCSCiuc062osl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092982 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9J6E1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiC9J6E1
PRIDEiC9J6E1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000460350; ENSP00000417896; ENSG00000114698
UCSCiuc062osl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000114698.14
HGNCiHGNC:16497 PLSCR4
OpenTargetsiENSG00000114698
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0621 Eukaryota
ENOG410XSYS LUCA
GeneTreeiENSGT00390000002884
HOGENOMiHOG000237356

Gene expression databases

BgeeiENSG00000114698 Expressed in 221 organ(s), highest expression level in germinal epithelium of ovary
ExpressionAtlasiC9J6E1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR005552 Scramblase
PANTHERiPTHR23248 PTHR23248, 1 hit
PfamiView protein in Pfam
PF03803 Scramblase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9J6E1_HUMAN
AccessioniPrimary (citable) accession number: C9J6E1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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