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Protein
Submitted name:

Rho GTPase-activating protein 4

Gene

ARHGAP4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Rho GTPase-activating protein 4Imported
Gene namesi
Name:ARHGAP4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000089820.15
HGNCiHGNC:674 ARHGAP4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089820

PTM / Processingi

Proteomic databases

PeptideAtlasiC9J5M2
PRIDEiC9J5M2

Expressioni

Gene expression databases

BgeeiENSG00000089820 Expressed in 189 organ(s), highest expression level in spleen
ExpressionAtlasiC9J5M2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9J5M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 176F-BARInterPro annotationAdd BLAST176

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili19 – 39Sequence analysisAdd BLAST21
Coiled coili127 – 168Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410INNV Eukaryota
ENOG410YF76 LUCA
GeneTreeiENSGT00760000118863
HOGENOMiHOG000039980

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
PfamiView protein in Pfam
PF00611 FCH, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

C9J5M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWQLSEQLR CLELQGELRR ELLQELAEFM RRRAEVELEY SRGLEKLAER
60 70 80 90 100
FSSRGGRLGS SREHQSFRKE PSLLSPLHCW AVLLQHTRQQ SRESAALSEV
110 120 130 140 150
LAGPLAQRLS HIAEDVGRLV KKSRDLEQQL QDELLEVVSE LQTAKKTYQA
160 170
YHMESVNAEA KLREAERQEE KRAGRS
Length:176
Mass (Da):20,479
Last modified:October 5, 2016 - v8
Checksum:i1CD4862571CB681F
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P98171RHG04_HUMAN
Rho GTPase-activating protein 4
ARHGAP4 KIAA0131, RGC1, RHOGAP4
946Annotation score:
E9PCM6E9PCM6_HUMAN
Rho GTPase-activating protein 4
ARHGAP4
768Annotation score:
E7EQN5E7EQN5_HUMAN
Rho GTPase-activating protein 4
ARHGAP4
925Annotation score:
A0A0B4J1X7A0A0B4J1X7_HUMAN
Rho GTPase activating protein 4, is...
ARHGAP4 hCG_39227
625Annotation score:
F8WAR0F8WAR0_HUMAN
Rho GTPase-activating protein 4
ARHGAP4
217Annotation score:
C9JLA8C9JLA8_HUMAN
Rho GTPase-activating protein 4
ARHGAP4
174Annotation score:
S4R314S4R314_HUMAN
Rho GTPase-activating protein 4
ARHGAP4
317Annotation score:
S4R352S4R352_HUMAN
Rho GTPase-activating protein 4
ARHGAP4
277Annotation score:
H7C3G3H7C3G3_HUMAN
Rho GTPase-activating protein 4
ARHGAP4
196Annotation score:
H7C3K8H7C3K8_HUMAN
Rho GTPase-activating protein 4
ARHGAP4
249Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei176Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF510182 Genomic DNA No translation available.
KF510654 Genomic DNA No translation available.
KF510656 Genomic DNA No translation available.
U52112 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000442262; ENSP00000398259; ENSG00000089820
UCSCiuc065bzb.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF510182 Genomic DNA No translation available.
KF510654 Genomic DNA No translation available.
KF510656 Genomic DNA No translation available.
U52112 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9J5M2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiC9J5M2
PRIDEiC9J5M2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442262; ENSP00000398259; ENSG00000089820
UCSCiuc065bzb.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000089820.15
HGNCiHGNC:674 ARHGAP4
OpenTargetsiENSG00000089820
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INNV Eukaryota
ENOG410YF76 LUCA
GeneTreeiENSGT00760000118863
HOGENOMiHOG000039980

Miscellaneous databases

ChiTaRSiARHGAP4 human

Gene expression databases

BgeeiENSG00000089820 Expressed in 189 organ(s), highest expression level in spleen
ExpressionAtlasiC9J5M2 baseline and differential

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
PfamiView protein in Pfam
PF00611 FCH, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9J5M2_HUMAN
AccessioniPrimary (citable) accession number: C9J5M2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 67 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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