Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Interleukin-6

Gene

IL6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-6Imported
Gene namesi
Name:IL6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000136244.11
HGNCiHGNC:6018 IL6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500299652328 – 152Sequence analysisAdd BLAST125

Proteomic databases

MaxQBiC9J5B0
PeptideAtlasiC9J5B0
PRIDEiC9J5B0

Expressioni

Gene expression databases

BgeeiENSG00000136244 Expressed in 143 organ(s), highest expression level in left coronary artery
ExpressionAtlasiC9J5B0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliC9J5B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
GeneTreeiENSGT00390000000878
HOGENOMiHOG000236330

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

C9J5B0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS
60 70 80 90 100
ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG
110 120 130 140 150
CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL

IQ
Length:152
Mass (Da):16,791
Last modified:November 3, 2009 - v1
Checksum:iEE1562147E15AF4F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P05231IL6_HUMAN
Interleukin-6
IL6 IFNB2
212Annotation score:
B5MC14B5MC14_HUMAN
Interleukin-6
IL6
198Annotation score:
B5MCZ3B5MCZ3_HUMAN
Interleukin-6
IL6
189Annotation score:
B5MC21B5MC21_HUMAN
Interleukin-6
IL6
136Annotation score:
B4DNV3B4DNV3_HUMAN
cDNA FLJ52006, moderately similar t...
IL6
122Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei152Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073072 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000426291; ENSP00000405150; ENSG00000136244
UCSCiuc064bxt.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073072 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9J5B0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiC9J5B0
PeptideAtlasiC9J5B0
PRIDEiC9J5B0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426291; ENSP00000405150; ENSG00000136244
UCSCiuc064bxt.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000136244.11
HGNCiHGNC:6018 IL6
OpenTargetsiENSG00000136244
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
GeneTreeiENSGT00390000000878
HOGENOMiHOG000236330

Miscellaneous databases

ChiTaRSiIL6 human

Gene expression databases

BgeeiENSG00000136244 Expressed in 143 organ(s), highest expression level in left coronary artery
ExpressionAtlasiC9J5B0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9J5B0_HUMAN
AccessioniPrimary (citable) accession number: C9J5B0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again