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UniProtKB - C9J4Z5 (C9J4Z5_HUMAN)
Protein
Submitted name:
Histone-lysine N-methyltransferase 2C
Gene
KMT2C
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- histone methyltransferase activity (H3-K4 specific) Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Histone-lysine N-methyltransferase 2CImported |
Gene namesi | Name:KMT2CImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13726, KMT2C |
VEuPathDBi | HostDB:ENSG00000055609 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- MLL3/4 complex Source: InterPro
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | C9J4Z5 |
PeptideAtlasi | C9J4Z5 |
PRIDEi | C9J4Z5 |
ProteomicsDBi | 8543 |
Expressioni
Gene expression databases
Bgeei | ENSG00000055609, Expressed in placenta and 230 other tissues |
ExpressionAtlasi | C9J4Z5, baseline and differential |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 81 | DisorderedSequence analysisAdd BLAST | 81 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 26 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 34 – 50 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
GeneTreei | ENSGT00940000155281 |
HOGENOMi | CLU_1699537_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR000637, HMGI/Y_DNA-bd_CS IPR037877, KMT2C |
PANTHERi | PTHR45888:SF1, PTHR45888:SF1, 1 hit |
PROSITEi | View protein in PROSITE PS00354, HMGI_Y, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 38 potential isoforms that are computationally mapped.Show allAlign All
C9J4Z5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSEEDKSVE QPQPPPPPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR
60 70 80 90 100
ARKKPRSRGK TAVEDEDSMD GLETTETETI VETAEIKEQS AEEDAEAEVD
110 120 130 140 150
NSKQLIPTLQ RSVSEESANS LVSVGVEAKI SEQLCAFCYC GEKSSLGQGD
LKQFR
Computationally mapped potential isoform sequencesi
There are 38 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8NEZ4 | KMT2C_HUMAN | Histone-lysine N-methyltransferase ... | KMT2C HALR, KIAA1506, MLL3 | 4,911 | Annotation score: | ||
A0A7P0TAI3 | A0A7P0TAI3_HUMAN | [Histone H3]-lysine(4) N-methyltran... | KMT2C | 4,762 | Annotation score: | ||
H7BY37 | H7BY37_HUMAN | [Histone H3]-lysine(4) N-methyltran... | KMT2C | 3,476 | Annotation score: | ||
A0A7P0T8F0 | A0A7P0T8F0_HUMAN | [Histone H3]-lysine(4) N-methyltran... | KMT2C | 3,207 | Annotation score: | ||
A0A7P0T9K8 | A0A7P0T9K8_HUMAN | [Histone H3]-lysine(4) N-methyltran... | KMT2C | 3,211 | Annotation score: | ||
H0Y765 | H0Y765_HUMAN | [Histone H3]-lysine(4) N-methyltran... | KMT2C | 1,766 | Annotation score: | ||
H7C2V8 | H7C2V8_HUMAN | [Histone H3]-lysine(4) N-methyltran... | KMT2C | 1,792 | Annotation score: | ||
A0A804HKS3 | A0A804HKS3_HUMAN | [Histone H3]-lysine(4) N-methyltran... | KMT2C | 4,054 | Annotation score: | ||
A0A804HKW4 | A0A804HKW4_HUMAN | [Histone H3]-lysine(4) N-methyltran... | KMT2C | 3,206 | Annotation score: | ||
A0A804HI08 | A0A804HI08_HUMAN | [Histone H3]-lysine(4) N-methyltran... | KMT2C | 1,789 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 155 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005631 Genomic DNA No translation available. AC006017 Genomic DNA No translation available. AC006474 Genomic DNA No translation available. AC104692 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000452749; ENSP00000410239; ENSG00000055609 |
UCSCi | uc064jmv.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005631 Genomic DNA No translation available. AC006017 Genomic DNA No translation available. AC006474 Genomic DNA No translation available. AC104692 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | C9J4Z5 |
PeptideAtlasi | C9J4Z5 |
PRIDEi | C9J4Z5 |
ProteomicsDBi | 8543 |
Protocols and materials databases
Antibodypediai | 33048, 88 antibodies from 22 providers |
Genome annotation databases
Ensembli | ENST00000452749; ENSP00000410239; ENSG00000055609 |
UCSCi | uc064jmv.1, human |
Organism-specific databases
HGNCi | HGNC:13726, KMT2C |
OpenTargetsi | ENSG00000055609 |
VEuPathDBi | HostDB:ENSG00000055609 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155281 |
HOGENOMi | CLU_1699537_0_0_1 |
Miscellaneous databases
ChiTaRSi | KMT2C, human |
Gene expression databases
Bgeei | ENSG00000055609, Expressed in placenta and 230 other tissues |
ExpressionAtlasi | C9J4Z5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000637, HMGI/Y_DNA-bd_CS IPR037877, KMT2C |
PANTHERi | PTHR45888:SF1, PTHR45888:SF1, 1 hit |
PROSITEi | View protein in PROSITE PS00354, HMGI_Y, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C9J4Z5_HUMAN | |
Accessioni | C9J4Z5Primary (citable) accession number: C9J4Z5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | January 19, 2022 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |