UniProtKB - C9J408 (C9J408_HUMAN)
Protein
Submitted name:
CASP8 and FADD-like apoptosis regulator
Gene
CFLAR
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
GO - Biological processi
- regulation of apoptotic process Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: CASP8 and FADD-like apoptosis regulatorImported |
Gene namesi | Name:CFLARImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000003402.19 |
HGNCi | HGNC:1876, CFLAR |
Expressioni
Gene expression databases
Bgeei | ENSG00000003402, Expressed in lower esophagus muscularis layer and 240 other tissues |
ExpressionAtlasi | C9J408, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 73 | DEDInterPro annotationAdd BLAST | 73 | |
Domaini | 92 – 129 | DEDInterPro annotationAdd BLAST | 38 |
Phylogenomic databases
GeneTreei | ENSGT00530000064199 |
HOGENOMi | CLU_2078351_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 1 hit |
SMARTi | View protein in SMART SM00031, DED, 1 hit |
SUPFAMi | SSF47986, SSF47986, 2 hits |
PROSITEi | View protein in PROSITE PS50168, DED, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
C9J408-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL
60 70 80 90 100
SVGDLAELLY RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI
110 120
GEDLDKSDVS SLIFLMKDYM GRGKISKEK
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO15519 | CFLAR_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR CASH, CASP8AP1, CLARP, MRIT | 480 | Annotation score: | ||
A0A0A0MR92 | A0A0A0MR92_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 321 | Annotation score: | ||
E9PAP3 | E9PAP3_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 250 | Annotation score: | ||
F8WBH9 | F8WBH9_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 243 | Annotation score: | ||
C9J4Q0 | C9J4Q0_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 64 | Annotation score: | ||
C9JV51 | C9JV51_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 118 | Annotation score: | ||
M0QYM0 | M0QYM0_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 168 | Annotation score: | ||
M0R1A8 | M0R1A8_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 117 | Annotation score: | ||
M0QY57 | M0QY57_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 117 | Annotation score: | ||
C9JSU3 | C9JSU3_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 62 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 129 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007283 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000441224; ENSP00000411897; ENSG00000003402 |
UCSCi | uc061rhz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007283 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | C9J408 |
PeptideAtlasi | C9J408 |
ProteomicsDBi | 8415 |
Protocols and materials databases
Antibodypediai | 19934, 924 antibodies |
Genome annotation databases
Ensembli | ENST00000441224; ENSP00000411897; ENSG00000003402 |
UCSCi | uc061rhz.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000003402.19 |
HGNCi | HGNC:1876, CFLAR |
OpenTargetsi | ENSG00000003402 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00530000064199 |
HOGENOMi | CLU_2078351_0_0_1 |
Miscellaneous databases
ChiTaRSi | CFLAR, human |
Gene expression databases
Bgeei | ENSG00000003402, Expressed in lower esophagus muscularis layer and 240 other tissues |
ExpressionAtlasi | C9J408, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 1 hit |
SMARTi | View protein in SMART SM00031, DED, 1 hit |
SUPFAMi | SSF47986, SSF47986, 2 hits |
PROSITEi | View protein in PROSITE PS50168, DED, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C9J408_HUMAN | |
Accessioni | C9J408Primary (citable) accession number: C9J408 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | October 7, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |