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Protein
Submitted name:

Ubiquitin-conjugating enzyme E2 E1

Gene

UBE2E1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiC9J2P0

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-conjugating enzyme E2 E1Imported
Gene namesi
Name:UBE2E1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000170142.11
HGNCiHGNC:12477 UBE2E1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170142

PTM / Processingi

Proteomic databases

MaxQBiC9J2P0
PeptideAtlasiC9J2P0
PRIDEiC9J2P0

Expressioni

Gene expression databases

BgeeiENSG00000170142 Expressed in 236 organ(s), highest expression level in embryo
ExpressionAtlasiC9J2P0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9J2P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 147UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST98

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

C9J2P0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDDSRAST SSSSSSSSNQ QTEKETNTPK KKESKVSMSK NSKLLSTSAK
60 70 80 90 100
RIQKELADIT LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI
110 120 130 140
TFTPEYPFKP PKVTFRTRIY HCNINSQGVI CLDILKDNWS PALTISK
Length:147
Mass (Da):16,210
Last modified:November 3, 2009 - v1
Checksum:iD15C1D9814F9B89F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P51965UB2E1_HUMAN
Ubiquitin-conjugating enzyme E2 E1
UBE2E1 UBCH6
193Annotation score:
B7Z306B7Z306_HUMAN
Ubiquitin-conjugating enzyme E2 E1
UBE2E1
167Annotation score:
H7C061H7C061_HUMAN
Ubiquitin-conjugating enzyme E2 E1
UBE2E1
151Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei147Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020626 Genomic DNA No translation available.
AC124914 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000442670; ENSP00000410652; ENSG00000170142
UCSCiuc062hmt.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020626 Genomic DNA No translation available.
AC124914 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9J2P0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiC9J2P0
PeptideAtlasiC9J2P0
PRIDEiC9J2P0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442670; ENSP00000410652; ENSG00000170142
UCSCiuc062hmt.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000170142.11
HGNCiHGNC:12477 UBE2E1
OpenTargetsiENSG00000170142
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455

Enzyme and pathway databases

SignaLinkiC9J2P0

Miscellaneous databases

ChiTaRSiUBE2E1 human

Gene expression databases

BgeeiENSG00000170142 Expressed in 236 organ(s), highest expression level in embryo
ExpressionAtlasiC9J2P0 baseline and differential

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9J2P0_HUMAN
AccessioniPrimary (citable) accession number: C9J2P0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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