UniProtKB - C9J2B5 (C9J2B5_HUMAN)
Protein
Submitted name:
Villin-1
Gene
VIL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin filament binding Source: InterPro
- calcium ion binding Source: InterPro
- phosphatidylinositol-4,5-bisphosphate binding Source: InterPro
GO - Biological processi
- actin filament capping Source: InterPro
- actin filament severing Source: InterPro
- actin nucleation Source: InterPro
Keywordsi
Molecular function | Actin-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Villin-1Imported |
Gene namesi | Name:VIL1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000127831.10 |
HGNCi | HGNC:12690, VIL1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127831, Expressed in small intestine and 121 other tissues |
ExpressionAtlasi | C9J2B5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 108 | Gelsolin-likeInterPro annotationAdd BLAST | 81 |
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160544 |
HOGENOMi | CLU_002568_4_2_1 |
Family and domain databases
Gene3Di | 3.40.20.10, 2 hits |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR030007, Villin IPR007122, Villin/Gelsolin |
PANTHERi | PTHR11977, PTHR11977, 1 hit PTHR11977:SF35, PTHR11977:SF35, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 1 hit |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
C9J2B5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKLSAQVKG SLNITTPGLQ IWRIEAMQMV PVPSSTFGSF FDGDCYIILA
60 70 80 90 100
IHKTASSLSY DIHYWIGQDS SLDEQGAAAI YTTQMDDFLK GRAVQHREVQ
110 120 130 140 150
GNESEAFRGY FKIRKGGVAS GMKHVETNSY DVQRLLHVKG KRNVVAGEVE
MSWKSFN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP09327 | VILI_HUMAN | Villin-1 | VIL1 VIL | 827 | Annotation score: | ||
B4DV78 | B4DV78_HUMAN | Villin-1 | VIL1 | 516 | Annotation score: | ||
H7C0B6 | H7C0B6_HUMAN | Villin-1 | VIL1 | 213 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 157 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021016 Genomic DNA No translation available. AC073838 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000454069; ENSP00000412657; ENSG00000127831 |
UCSCi | uc061slp.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021016 Genomic DNA No translation available. AC073838 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | C9J2B5 |
PRIDEi | C9J2B5 |
ProteomicsDBi | 8185 |
Protocols and materials databases
Antibodypediai | 1531, 652 antibodies |
Genome annotation databases
Ensembli | ENST00000454069; ENSP00000412657; ENSG00000127831 |
UCSCi | uc061slp.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000127831.10 |
HGNCi | HGNC:12690, VIL1 |
OpenTargetsi | ENSG00000127831 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160544 |
HOGENOMi | CLU_002568_4_2_1 |
Miscellaneous databases
ChiTaRSi | VIL1, human |
Gene expression databases
Bgeei | ENSG00000127831, Expressed in small intestine and 121 other tissues |
ExpressionAtlasi | C9J2B5, baseline and differential |
Family and domain databases
Gene3Di | 3.40.20.10, 2 hits |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR030007, Villin IPR007122, Villin/Gelsolin |
PANTHERi | PTHR11977, PTHR11977, 1 hit PTHR11977:SF35, PTHR11977:SF35, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 1 hit |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C9J2B5_HUMAN | |
Accessioni | C9J2B5Primary (citable) accession number: C9J2B5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | October 5, 2016 | |
Last modified: | August 12, 2020 | |
This is version 70 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |