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UniProtKB - C9IZL7 (C9IZL7_HUMAN)
Protein
Submitted name:
Non-POU domain-containing octamer-binding protein
Gene
NONO
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Non-POU domain-containing octamer-binding proteinImported |
Gene namesi | Name:NONOImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7871, NONO |
VEuPathDBi | HostDB:ENSG00000147140 |
PTM / Processingi
Proteomic databases
MaxQBi | C9IZL7 |
PeptideAtlasi | C9IZL7 |
PRIDEi | C9IZL7 |
ProteomicsDBi | 7820 |
PTM databases
SwissPalmi | C9IZL7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147140, Expressed in subventricular zone (inner) (primate) and 133 other tissues |
ExpressionAtlasi | C9IZL7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 146 | RRMInterPro annotationAdd BLAST | 73 | |
Domaini | 148 – 207 | RRMInterPro annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 51 | DisorderedSequence analysisAdd BLAST | 51 |
Phylogenomic databases
HOGENOMi | CLU_027185_0_1_1 |
Family and domain databases
CDDi | cd12588, RRM1_p54nrb, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR034552, p54nrb_RRM1 IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All
C9IZL7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSNKTFNLE KQNHTPRKHH QHHHQQQHHQ QQQQQPPPPP IPANGQQASS
60 70 80 90 100
QNEGLTIDLK NFRKPGEKTF TQRSRLFVGN LPPDITEEEM RKLFEKYGKA
110 120 130 140 150
GEVFIHKDKG FGFIRLETRT LAEIAKVELD NMPLRGKQLR VRFACHSASL
160 170 180 190 200
TVRNLPQYVS NELLEEAFSV FGQVERAVVI VDDRGRPSGK GIVEFSGKPA
ARKALDR
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ15233 | NONO_HUMAN | Non-POU domain-containing octamer-b... | NONO NRB54 | 471 | Annotation score: | ||
A0A7I2V4J2 | A0A7I2V4J2_HUMAN | Non-POU domain-containing octamer-b... | NONO | 468 | Annotation score: | ||
A0A7I2V535 | A0A7I2V535_HUMAN | Non-POU domain-containing octamer-b... | NONO | 501 | Annotation score: | ||
C9J4X2 | C9J4X2_HUMAN | Non-POU domain-containing octamer-b... | NONO | 124 | Annotation score: | ||
C9JYS8 | C9JYS8_HUMAN | Non-POU domain-containing octamer-b... | NONO | 247 | Annotation score: | ||
A0A7I2V464 | A0A7I2V464_HUMAN | Non-POU domain-containing octamer-b... | NONO | 360 | Annotation score: | ||
A0A7I2V4K9 | A0A7I2V4K9_HUMAN | Non-POU domain-containing octamer-b... | NONO | 411 | Annotation score: | ||
A0A7I2V4N2 | A0A7I2V4N2_HUMAN | Non-POU domain-containing octamer-b... | NONO | 360 | Annotation score: | ||
A0A7I2V5Y7 | A0A7I2V5Y7_HUMAN | Non-POU domain-containing octamer-b... | NONO | 476 | Annotation score: | ||
A0A7P0MRW0 | A0A7P0MRW0_HUMAN | Non-POU domain-containing octamer-b... | NONO | 515 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 207 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590762 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000454976; ENSP00000406673; ENSG00000147140 |
UCSCi | uc064zus.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590762 Genomic DNA No translation available. |
3D structure databases
SMRi | C9IZL7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | C9IZL7, 1 interactor |
PTM databases
SwissPalmi | C9IZL7 |
Proteomic databases
MaxQBi | C9IZL7 |
PeptideAtlasi | C9IZL7 |
PRIDEi | C9IZL7 |
ProteomicsDBi | 7820 |
Protocols and materials databases
Antibodypediai | 13516, 546 antibodies from 43 providers |
Genome annotation databases
Ensembli | ENST00000454976; ENSP00000406673; ENSG00000147140 |
UCSCi | uc064zus.1, human |
Organism-specific databases
HGNCi | HGNC:7871, NONO |
OpenTargetsi | ENSG00000147140 |
VEuPathDBi | HostDB:ENSG00000147140 |
GenAtlasi | Search... |
Phylogenomic databases
HOGENOMi | CLU_027185_0_1_1 |
Miscellaneous databases
ChiTaRSi | NONO, human |
Gene expression databases
Bgeei | ENSG00000147140, Expressed in subventricular zone (inner) (primate) and 133 other tissues |
ExpressionAtlasi | C9IZL7, baseline and differential |
Family and domain databases
CDDi | cd12588, RRM1_p54nrb, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR034552, p54nrb_RRM1 IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | C9IZL7_HUMAN | |
Accessioni | C9IZL7Primary (citable) accession number: C9IZL7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | May 25, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |