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Protein
Submitted name:

Patatin-like phospholipase domain-containing protein 4

Gene

PNPLA4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43NucleophilePROSITE-ProRule annotation1
Active sitei163Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation
Biological processLipid degradationPROSITE-ProRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Submitted name:
Patatin-like phospholipase domain-containing protein 4Imported
Gene namesi
Name:PNPLA4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000006757.11
HGNCiHGNC:24887 PNPLA4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000006757

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500299755925 – 190Sequence analysisAdd BLAST166

Proteomic databases

MaxQBiC9IZF6
PeptideAtlasiC9IZF6
PRIDEiC9IZF6

Expressioni

Gene expression databases

BgeeiENSG00000006757 Expressed in 212 organ(s), highest expression level in oocyte
ExpressionAtlasiC9IZF6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9IZF6
SMRiC9IZF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 176PNPLAInterPro annotationAdd BLAST171

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 45GXSXGPROSITE-ProRule annotation5
Motifi163 – 165DGA/GPROSITE-ProRule annotation3

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3773 Eukaryota
ENOG410XSQS LUCA
GeneTreeiENSGT00390000005295
HOGENOMiHOG000007467

Family and domain databases

CDDicd07222 Pat_PNPLA4, 1 hit
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR033562 PLPL
IPR033902 PNPLA4
IPR002641 PNPLA_dom
PANTHERiPTHR12406 PTHR12406, 1 hit
PTHR12406:SF39 PTHR12406:SF39, 1 hit
PfamiView protein in Pfam
PF01734 Patatin, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51635 PNPLA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

C9IZF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKHINLSFAA CGFLGIYHLG AASALCRHGK KLVKDVKAFA GASAGSLVAS
60 70 80 90 100
VLLTAPEKIE ECNQFTYKFA EEIRRQSFGA VTPGYDFMAR LRSGMESILP
110 120 130 140 150
PSAHELAQNR LHVSITNAKT RENHLVSTFS SREDLIKVLL ASSFVPIYAG
160 170 180 190
LKLVEYKGQK WVDGGLTNAL PILPVGRTVT ISPFSGRLDI
Length:190
Mass (Da):20,649
Last modified:November 3, 2009 - v1
Checksum:iB244E7B144697C64
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P41247PLPL4_HUMAN
Patatin-like phospholipase domain-c...
PNPLA4 DXS1283E, GS2
253Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei190Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005296 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000442940; ENSP00000406698; ENSG00000006757
UCSCiuc064xxg.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005296 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9IZF6
SMRiC9IZF6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiC9IZF6
PeptideAtlasiC9IZF6
PRIDEiC9IZF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442940; ENSP00000406698; ENSG00000006757
UCSCiuc064xxg.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000006757.11
HGNCiHGNC:24887 PNPLA4
OpenTargetsiENSG00000006757
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3773 Eukaryota
ENOG410XSQS LUCA
GeneTreeiENSGT00390000005295
HOGENOMiHOG000007467

Gene expression databases

BgeeiENSG00000006757 Expressed in 212 organ(s), highest expression level in oocyte
ExpressionAtlasiC9IZF6 baseline and differential

Family and domain databases

CDDicd07222 Pat_PNPLA4, 1 hit
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR033562 PLPL
IPR033902 PNPLA4
IPR002641 PNPLA_dom
PANTHERiPTHR12406 PTHR12406, 1 hit
PTHR12406:SF39 PTHR12406:SF39, 1 hit
PfamiView protein in Pfam
PF01734 Patatin, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51635 PNPLA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9IZF6_HUMAN
AccessioniPrimary (citable) accession number: C9IZF6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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