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Protein
Submitted name:

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

Gene

GCAT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialImported
Gene namesi
Name:GCATImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100116.16
HGNCiHGNC:4188 GCAT

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100116

PTM / Processingi

Proteomic databases

MaxQBiC9IZC9
PaxDbiC9IZC9
PeptideAtlasiC9IZC9
PRIDEiC9IZC9

Expressioni

Gene expression databases

BgeeiENSG00000100116 Expressed in 195 organ(s), highest expression level in body of pancreas
ExpressionAtlasiC9IZC9 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371110

Structurei

3D structure databases

ProteinModelPortaliC9IZC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 169Aminotran_1_2InterPro annotationAdd BLAST77

Phylogenomic databases

eggNOGiKOG1359 Eukaryota
COG0156 LUCA
GeneTreeiENSGT00530000063111
HOGENOMiHOG000221022

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR011282 2am3keto_CoA_ligase
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR13693:SF60 PTHR13693:SF60, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

C9IZC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPGNAWRAA LFWVPRGRRA QSALAQLRGI LEGELEGIRG AGTWKSERVI
60 70 80 90 100
TSRQGPHIRV DGVSGGPGTV IFPGLPLPHL SCCIHLLSFT SGILNFCANN
110 120 130 140 150
YLGLSSHPEV IQAGLQALEE FGAGLSSVRF ICGTQSIHKN LEAKIARFHQ
160 170
REDAILYPSC YDANAGLFES RALVQPG
Length:177
Mass (Da):19,177
Last modified:November 3, 2009 - v1
Checksum:i8FB1A1499B8B765F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O75600KBL_HUMAN
2-amino-3-ketobutyrate coenzyme A l...
GCAT KBL
419Annotation score:
H7BZ75H7BZ75_HUMAN
2-amino-3-ketobutyrate coenzyme A l...
GCAT
239Annotation score:
F2Z340F2Z340_HUMAN
2-amino-3-ketobutyrate coenzyme A l...
GCAT
91Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei177Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97630 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000445195; ENSP00000406719; ENSG00000100116
UCSCiuc062eai.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97630 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9IZC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371110

Proteomic databases

MaxQBiC9IZC9
PaxDbiC9IZC9
PeptideAtlasiC9IZC9
PRIDEiC9IZC9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445195; ENSP00000406719; ENSG00000100116
UCSCiuc062eai.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000100116.16
HGNCiHGNC:4188 GCAT
OpenTargetsiENSG00000100116
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1359 Eukaryota
COG0156 LUCA
GeneTreeiENSGT00530000063111
HOGENOMiHOG000221022

Gene expression databases

BgeeiENSG00000100116 Expressed in 195 organ(s), highest expression level in body of pancreas
ExpressionAtlasiC9IZC9 baseline and differential

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR011282 2am3keto_CoA_ligase
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR13693:SF60 PTHR13693:SF60, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9IZC9_HUMAN
AccessioniPrimary (citable) accession number: C9IZC9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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