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Protein
Submitted name:

Adenosine deaminase 2

Gene

ADA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Adenosine deaminase 2Imported
Gene namesi
Name:ADA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000093072.15
HGNCiHGNC:1839 ADA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000093072

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500299755830 – 135Sequence analysisAdd BLAST106

Proteomic databases

MaxQBiC9IZA8
PeptideAtlasiC9IZA8
PRIDEiC9IZA8

Expressioni

Gene expression databases

BgeeiENSG00000093072 Expressed in 197 organ(s), highest expression level in leukocyte
ExpressionAtlasiC9IZA8 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 102A_deaminase_NInterPro annotationAdd BLAST75

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1097 Eukaryota
COG1816 LUCA
GeneTreeiENSGT00390000012118

Family and domain databases

InterProiView protein in InterPro
IPR013659 A_deaminase_N
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF08451 A_deaminase_N, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

C9IZA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVDGPSERP ALCFLLLAVA MSFFGSALSI DETRAHLLLK EKMMRLGGRL
60 70 80 90 100
VLNTKEELAN ERLMTLKIAE MKEAMRTLIF PPSMHFFQAK HLIERSQVFN
110 120 130
ILRMMPKGAA LHLHDIGIVT MDWLVRNVTY RPHCH
Length:135
Mass (Da):15,500
Last modified:November 3, 2009 - v1
Checksum:i75E65A4C5B9F200B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NZK5ADA2_HUMAN
Adenosine deaminase 2
ADA2 ADGF, CECR1, IDGFL
511Annotation score:
B4E3Q4B4E3Q4_HUMAN
Adenosine deaminase 2
ADA2
469Annotation score:
A0A087X0I3A0A087X0I3_HUMAN
Adenosine deaminase 2
ADA2
391Annotation score:
F5H7J3F5H7J3_HUMAN
Adenosine deaminase 2
ADA2
152Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei135Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005300 Genomic DNA No translation available.
AC005399 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000441548; ENSP00000392078; ENSG00000093072
UCSCiuc062bgf.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005300 Genomic DNA No translation available.
AC005399 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiC9IZA8
PeptideAtlasiC9IZA8
PRIDEiC9IZA8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000441548; ENSP00000392078; ENSG00000093072
UCSCiuc062bgf.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000093072.15
HGNCiHGNC:1839 ADA2
OpenTargetsiENSG00000093072
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1097 Eukaryota
COG1816 LUCA
GeneTreeiENSGT00390000012118

Gene expression databases

BgeeiENSG00000093072 Expressed in 197 organ(s), highest expression level in leukocyte
ExpressionAtlasiC9IZA8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013659 A_deaminase_N
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF08451 A_deaminase_N, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9IZA8_HUMAN
AccessioniPrimary (citable) accession number: C9IZA8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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