UniProtKB - C9IZ88 (C9IZ88_HUMAN)
Protein
Submitted name:
Catenin alpha-2
Gene
CTNNA2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin filament binding Source: InterPro
- cadherin binding Source: InterPro
GO - Biological processi
- cell adhesion Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Catenin alpha-2Imported |
Gene namesi | Name:CTNNA2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000066032.18 |
HGNCi | HGNC:2510, CTNNA2 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000066032, Expressed in frontal pole and 160 other tissues |
ExpressionAtlasi | C9IZ88, baseline and differential |
Interactioni
GO - Molecular functioni
- actin filament binding Source: InterPro
- cadherin binding Source: InterPro
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 79 – 99 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the vinculin/alpha-catenin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT01010000222422 |
HOGENOMi | CLU_121716_1_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR036723, Alpha-catenin/vinculin-like_sf IPR001033, Alpha_catenin IPR006077, Vinculin/catenin |
PANTHERi | PTHR18914, PTHR18914, 1 hit |
Pfami | View protein in Pfam PF01044, Vinculin, 1 hit |
PRINTSi | PR00805, ALPHACATENIN |
SUPFAMi | SSF47220, SSF47220, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
C9IZ88-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK
60 70 80 90 100
KGRSKKAHVL AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG
110
ETMRIASSEF ADDPCSS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP26232 | CTNA2_HUMAN | Catenin alpha-2 | CTNNA2 CAPR | 953 | Annotation score: | ||
A0A0A0MRI5 | A0A0A0MRI5_HUMAN | Catenin alpha-2 | CTNNA2 | 569 | Annotation score: | ||
A0A0A0MTJ6 | A0A0A0MTJ6_HUMAN | Catenin alpha-2 | CTNNA2 | 476 | Annotation score: | ||
B9A010 | B9A010_HUMAN | Catenin alpha-2 | CTNNA2 | 190 | Annotation score: | ||
C9J144 | C9J144_HUMAN | Catenin alpha-2 | CTNNA2 | 66 | Annotation score: | ||
B8ZZE7 | B8ZZE7_HUMAN | Catenin alpha-2 | CTNNA2 | 44 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 117 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010975 Genomic DNA No translation available. AC011746 Genomic DNA No translation available. AC011754 Genomic DNA No translation available. AC016716 Genomic DNA No translation available. AC018733 Genomic DNA No translation available. AC093322 Genomic DNA No translation available. AC096573 Genomic DNA No translation available. AC096753 Genomic DNA No translation available. FJ695201 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000409971; ENSP00000387073; ENSG00000066032 |
UCSCi | uc061lco.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010975 Genomic DNA No translation available. AC011746 Genomic DNA No translation available. AC011754 Genomic DNA No translation available. AC016716 Genomic DNA No translation available. AC018733 Genomic DNA No translation available. AC093322 Genomic DNA No translation available. AC096573 Genomic DNA No translation available. AC096753 Genomic DNA No translation available. FJ695201 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | C9IZ88 |
PeptideAtlasi | C9IZ88 |
ProteomicsDBi | 7767 |
Protocols and materials databases
Antibodypediai | 8335, 118 antibodies |
Genome annotation databases
Ensembli | ENST00000409971; ENSP00000387073; ENSG00000066032 |
UCSCi | uc061lco.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000066032.18 |
HGNCi | HGNC:2510, CTNNA2 |
OpenTargetsi | ENSG00000066032 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01010000222422 |
HOGENOMi | CLU_121716_1_0_1 |
Miscellaneous databases
ChiTaRSi | CTNNA2, human |
Gene expression databases
Bgeei | ENSG00000066032, Expressed in frontal pole and 160 other tissues |
ExpressionAtlasi | C9IZ88, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR036723, Alpha-catenin/vinculin-like_sf IPR001033, Alpha_catenin IPR006077, Vinculin/catenin |
PANTHERi | PTHR18914, PTHR18914, 1 hit |
Pfami | View protein in Pfam PF01044, Vinculin, 1 hit |
PRINTSi | PR00805, ALPHACATENIN |
SUPFAMi | SSF47220, SSF47220, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C9IZ88_HUMAN | |
Accessioni | C9IZ88Primary (citable) accession number: C9IZ88 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |