We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - C8Z6M6 (MPH3_YEAS8)
Protein
Alpha-glucosides permease MPH3
Gene
MPH3
Organism
Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast)
Status
Functioni
High-affinity uptake of maltose and maltotriose. Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose (By similarity).
By similarityGO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
- maltose metabolic process Source: UniProtKB-KW
Keywordsi
Biological process | Maltose metabolism, Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-glucosides permease MPH3Alternative name(s): Maltose transport protein 3 |
Gene namesi | Name:MPH3 ORF Names:EC1118_1D22_0023g |
Organismi | Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast) |
Taxonomic identifieri | 643680 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 106 | CytoplasmicBy similarityAdd BLAST | 106 | |
Transmembranei | 107 – 127 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 128 – 142 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 143 – 163 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 164 – 178 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 179 – 199 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 200 | ExtracellularBy similarity | 1 | |
Transmembranei | 201 – 221 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 222 – 234 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 235 – 255 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 256 – 270 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 271 – 291 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 292 – 363 | CytoplasmicBy similarityAdd BLAST | 72 | |
Transmembranei | 364 – 384 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 385 – 397 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 398 – 418 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 419 – 426 | CytoplasmicBy similarity | 8 | |
Transmembranei | 427 – 447 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 448 – 459 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 460 – 480 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 481 – 492 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 493 – 513 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 514 – 525 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 526 – 546 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 547 – 602 | CytoplasmicBy similarityAdd BLAST | 56 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000391713 | 1 – 602 | Alpha-glucosides permease MPH3Add BLAST | 602 |
Expressioni
Inductioni
By maltose and maltotriose. Repressed by glucose (By similarity).By similarity
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 580 – 602 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 585 – 602 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_001265_11_5_1 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
C8Z6M6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNLSFLINR RKENTSDSNV YPGKAKSHEP SWIEMDDQTK KDGLDIVHVE
60 70 80 90 100
FSPDTRAPSD SNKVITEIFD ATEDAKEADE SERGMPLATA LNTYPKAAAW
110 120 130 140 150
SLLVSTTLIM EGYDTAILGA FYALPIFQRK FGSQNDKTGE WEISASWQIG
160 170 180 190 200
LTLCYMAGEI VGLQLTGPSV DLVGNRYTLI IALFFLAAFT FILYFCNSLG
210 220 230 240 250
MIAVGQALCG MPWGCFQCLT VSYASEICPL ALRYYLTTYS NLCWLFGQLF
260 270 280 290 300
AAGIMKNSQK KYADSELGYK LPFALQWILP VPLALGIFFA PESPWWLVKK
310 320 330 340 350
GRFDEARRSL RRTLSGKGPE KEILVTLEVD KIKVTIDKEK RLTSKEGSYS
360 370 380 390 400
DCFEDKINRR RTRITCLCWA GQATCGSILI GYSTYFYEKA GVSTEMSFTF
410 420 430 440 450
SIIQYCLGIC ATFLSWWASK YFGRYDLYAF GLAFQTIVFF IIGGLGCSST
460 470 480 490 500
HGSKMGSGSL LMAVAFFYNL GIAPVVFRLV SEMPSSRLRT KTIILARNTY
510 520 530 540 550
NVVSIICSVL ILYQLNSKKW NWGAKSGFFW GVLCFCTLIW AVVDLPETAG
560 570 580 590 600
KTFVEINELF KLGVSARKFK STKVDPFVVK NPPKDVSHND PKGDIEASIA
EE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FN393064 Genomic DNA Translation: CAY79042.1 |
Genome annotation databases
EnsemblFungii | CAY79042; CAY79042; EC1118_1D22_0023g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FN393064 Genomic DNA Translation: CAY79042.1 |
3D structure databases
SMRi | C8Z6M6 |
ModBasei | Search... |
Genome annotation databases
EnsemblFungii | CAY79042; CAY79042; EC1118_1D22_0023g |
Phylogenomic databases
HOGENOMi | CLU_001265_11_5_1 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MPH3_YEAS8 | |
Accessioni | C8Z6M6Primary (citable) accession number: C8Z6M6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 2, 2010 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 23, 2022 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |