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Protein

Lipoxygenase homology domain-containing protein 1

Gene

Loxhd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal function of hair cells in the inner ear.1 Publication

GO - Molecular functioni

GO - Biological processi

  • sensory perception of sound Source: MGI

Keywordsi

Biological processHearing

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoxygenase homology domain-containing protein 1
Gene namesi
Name:Loxhd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914609 Loxhd1

Subcellular locationi

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003933301 – 2068Lipoxygenase homology domain-containing protein 1Add BLAST2068

Proteomic databases

PaxDbiC8YR32
PRIDEiC8YR32

PTM databases

iPTMnetiC8YR32
PhosphoSitePlusiC8YR32

Expressioni

Tissue specificityi

Expressed in the inner ear, specifically in hair cells. Higher expression is detected in the cochlea.1 Publication

Gene expression databases

BgeeiENSMUSG00000032818 Expressed in 8 organ(s), highest expression level in testis
ExpressionAtlasiC8YR32 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi232198, 1 interactor
STRINGi10090.ENSMUSP00000094294

Structurei

3D structure databases

ProteinModelPortaliC8YR32
SMRiC8YR32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 160PLAT 1PROSITE-ProRule annotationAdd BLAST118
Domaini172 – 287PLAT 2PROSITE-ProRule annotationAdd BLAST116
Domaini296 – 412PLAT 3PROSITE-ProRule annotationAdd BLAST117
Domaini425 – 540PLAT 4PROSITE-ProRule annotationAdd BLAST116
Domaini553 – 673PLAT 5PROSITE-ProRule annotationAdd BLAST121
Domaini684 – 803PLAT 6PROSITE-ProRule annotationAdd BLAST120
Domaini814 – 934PLAT 7PROSITE-ProRule annotationAdd BLAST121
Domaini970 – 1088PLAT 8PROSITE-ProRule annotationAdd BLAST119
Domaini1101 – 1226PLAT 9PROSITE-ProRule annotationAdd BLAST126
Domaini1255 – 1373PLAT 10PROSITE-ProRule annotationAdd BLAST119
Domaini1422 – 1540PLAT 11PROSITE-ProRule annotationAdd BLAST119
Domaini1553 – 1668PLAT 12PROSITE-ProRule annotationAdd BLAST116
Domaini1680 – 1798PLAT 13PROSITE-ProRule annotationAdd BLAST119
Domaini1811 – 1932PLAT 14PROSITE-ProRule annotationAdd BLAST122
Domaini1949 – 2065PLAT 15PROSITE-ProRule annotationAdd BLAST117

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJEB Eukaryota
ENOG410XTDU LUCA
GeneTreeiENSGT00390000018830
HOGENOMiHOG000030975
InParanoidiC8YR32
OrthoDBiEOG091G00F7
TreeFamiTF350466

Family and domain databases

Gene3Di2.40.180.10, 11 hits
InterProiView protein in InterPro
IPR037060 Catalase_core_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PfamiView protein in Pfam
PF01477 PLAT, 15 hits
SMARTiView protein in SMART
SM00308 LH2, 13 hits
SUPFAMiSSF49723 SSF49723, 15 hits
PROSITEiView protein in PROSITE
PS50095 PLAT, 15 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

C8YR32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAQKKKRRK KDIDFLGLYE EELLNYDSED GEDELEHEYY KAKVYEVVTA
60 70 80 90 100
TGDVRGAGTD ANVFITLFGE NGLSPKLHLT SKSESAFEKA NVDVFRVRTN
110 120 130 140 150
NVGLIYKIRI EHDNTGLNAS WYLDRVIVTD MKRPHLRYYF NCNNWLSKVE
160 170 180 190 200
GDRQWCRDLL ASFDPMDMPR GNKYEIKVYT GDVIGAGTDA DVFINIFGEY
210 220 230 240 250
GDTGERRLEN EKDNFEKGAE DKFTLDAPDL GQLMKINVGH NNKGGSAGWF
260 270 280 290 300
LSKIIIEDIG NKRKYDFPLN RWLALDEDDG KIQRDILVGG AETTAITYIV
310 320 330 340 350
TVFTGDIRGA GTKSKIYLVM YGARGNKNSG KIFLEGGVFD RGRTDIFHID
360 370 380 390 400
LAVLLSPLSR VSIGHGNIGV NRGWYCEKVV ILCPFTGIQQ TFPCSNWLDE
410 420 430 440 450
KKADGLIERQ LYEMVSLRKK RLKKYPWSLW VWTTDLKKAG TNSPIFIQIY
460 470 480 490 500
GKKGRTDEIL LNPNNKWFKP GIIEKFRMEL PDLGRFYKIR AWHDRQNPGS
510 520 530 540 550
GWHLEKMTLM NTINKDKYNF NCNRWLDANE DDNEIVREMT AEGPTVRRIM
560 570 580 590 600
GMARYRVTVC TGELEGAGTD ANVYLCLFGD VGDTGERLLY NCRNNTDLFE
610 620 630 640 650
KGNADEFTIE SVTMRKVRRV RVRHDGKGSG SGWYLDRVLV REEGQPESDN
660 670 680 690 700
VEFPCLRWLD KDKDDGQLVR ELLPSDSNAT LKNFRYHISV KTGDVSGAST
710 720 730 740 750
DSRVYIKLYG EKSDTIKQVL LVSDNNLKDY FERGRVDEFT LETLNIGTIN
760 770 780 790 800
RLVIGHDSTG MHAGWFLGSV QIRVPRQGKQ YTFPANRWLD KNQADGRLEV
810 820 830 840 850
ELYPSEVVEI QKLVHYEIEI WTGDVGGAGT TSRVFVQIYG EEGKTEVLFL
860 870 880 890 900
SSRSKVFDRG SKDIFQTDTF TIYAIDLGAL TKIRIRHDNT GNRPGWFLDR
910 920 930 940 950
VDITDVNNET TYYFPCQRWL AVEEDDGQLS RELLPVDESY VLPSEDEEGG
960 970 980 990 1000
GQGDNNPLDN LALEQKDKST TFSVTIKTGD KKNAGTDANV FITLFGTQDN
1010 1020 1030 1040 1050
NGMTLLKSSK TNSDKFERDS IEIFTVETLD LGDLWKVRIG HDNTGKAPGW
1060 1070 1080 1090 1100
FVDWVEVDAP SLGKCMTFPC GRWLAKNEDD GSIVRDLFHA ELQTRLYTPF
1110 1120 1130 1140 1150
VPYEITLYTS DVFAAGTDAN IFIVIYGCDA VCTRQKFLCT NKREQKLFFE
1160 1170 1180 1190 1200
RKSASRFIVE LEDVGEIIEK IRIGHDNTGI NPGWHCSHVD IRRLLPEKDG
1210 1220 1230 1240 1250
TETLTFPCDR WLATSEDDKK TIRELVPYDI FTEKYMKDGS LRQVYKEVEE
1260 1270 1280 1290 1300
PLDIVLYSVQ IFTGNVPGAG TDAKVYITIY GDLGDTGERY LGKSENRTNK
1310 1320 1330 1340 1350
FEKGTADTFI IEAADLGVIY KIKLRHDNTK WCADWYVEKV EIWNDTNEDE
1360 1370 1380 1390 1400
FLFLCGRWLS LKKEDGRLER LFYEKEYTGD RSSNCSSPAD FWEIALSSKM
1410 1420 1430 1440 1450
ADVDIDTVTG PMVDYVQDGP VIPYYVSVTT GKHKEAATDS RAFVLLIGED
1460 1470 1480 1490 1500
DECTNRIWLD YPQGKRGFSC GSVEEFYVGG LDVGIIKKIE LGHDGASPES
1510 1520 1530 1540 1550
CWLVEELCLA VPTQGTKYTL RCNCWLAKDR GDGVTSRVFD LLDAMVVNIG
1560 1570 1580 1590 1600
KKVLYEMTVW TGDVVGGGTD SNIFMTLYGI NGSTEEVQLD KKKARFEREQ
1610 1620 1630 1640 1650
NDTFIMEILD IAPFTKMRIR IDGMGSRPEW FLERILLKNM NTGDLTMFYY
1660 1670 1680 1690 1700
GDWLSQKKGK KTLVCEICAV IDGEEMMEWT SYTVSVKTSD ILGAGTDANV
1710 1720 1730 1740 1750
FIIIFGENGD SGTLALKQSA NWNKFERNNT DTFNFSDMLS LGHLCKLRVW
1760 1770 1780 1790 1800
HDNKGIFPGW HLSYVDVKDN SRDETFRFQC DCWLSKSEGD RQTLRDFACA
1810 1820 1830 1840 1850
NNEIRDELEE TTYEIVIETG NGGETRENVW LILEGRKNRS KEFLVENSSR
1860 1870 1880 1890 1900
QRAFRKGTTD TFEFDSIFLG DIASLCVGHL AREDRFIPKR ELVWHVKTIT
1910 1920 1930 1940 1950
ITEMEYGNVY FFNCDCLIPL KRKRKYFKVF EVTKTTESFA SKIQSLVPVK
1960 1970 1980 1990 2000
YEVIVTTGYE PGAGTDANVF VTIFGANGDT GKRELKQKMR NLFERGSTDR
2010 2020 2030 2040 2050
FFLETLELGE LRKVRLEHDS SGYYSGWLVE KVEVTNTSTG VATIFSCGRW
2060
LDKSRGDGLT WRELFPSV
Length:2,068
Mass (Da):235,757
Last modified:November 3, 2009 - v1
Checksum:i65B9CEE21632016B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUR7D3YUR7_MOUSE
Lipoxygenase homology domain-contai...
Loxhd1
1,478Annotation score:
E9PVB2E9PVB2_MOUSE
Lipoxygenase homology domain-contai...
Loxhd1
996Annotation score:
F6XPZ0F6XPZ0_MOUSE
Lipoxygenase homology domain-contai...
Loxhd1
1,214Annotation score:
F6QGA9F6QGA9_MOUSE
Lipoxygenase homology domain-contai...
Loxhd1
516Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1342I → N in the samba murine model of hearing loss. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ750876 mRNA Translation: ACV52550.1
AK007091 mRNA Translation: BAC25164.1
CCDSiCCDS50326.1
RefSeqiNP_766422.2, NM_172834.2
UniGeneiMm.380247

Genome annotation databases

EnsembliENSMUST00000096547; ENSMUSP00000094294; ENSMUSG00000032818
GeneIDi240411
KEGGimmu:240411
UCSCiuc012bfd.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ750876 mRNA Translation: ACV52550.1
AK007091 mRNA Translation: BAC25164.1
CCDSiCCDS50326.1
RefSeqiNP_766422.2, NM_172834.2
UniGeneiMm.380247

3D structure databases

ProteinModelPortaliC8YR32
SMRiC8YR32
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232198, 1 interactor
STRINGi10090.ENSMUSP00000094294

PTM databases

iPTMnetiC8YR32
PhosphoSitePlusiC8YR32

Proteomic databases

PaxDbiC8YR32
PRIDEiC8YR32

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096547; ENSMUSP00000094294; ENSMUSG00000032818
GeneIDi240411
KEGGimmu:240411
UCSCiuc012bfd.1 mouse

Organism-specific databases

CTDi125336
MGIiMGI:1914609 Loxhd1

Phylogenomic databases

eggNOGiENOG410IJEB Eukaryota
ENOG410XTDU LUCA
GeneTreeiENSGT00390000018830
HOGENOMiHOG000030975
InParanoidiC8YR32
OrthoDBiEOG091G00F7
TreeFamiTF350466

Miscellaneous databases

ChiTaRSiLoxhd1 mouse
PROiPR:C8YR32
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032818 Expressed in 8 organ(s), highest expression level in testis
ExpressionAtlasiC8YR32 baseline and differential

Family and domain databases

Gene3Di2.40.180.10, 11 hits
InterProiView protein in InterPro
IPR037060 Catalase_core_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PfamiView protein in Pfam
PF01477 PLAT, 15 hits
SMARTiView protein in SMART
SM00308 LH2, 13 hits
SUPFAMiSSF49723 SSF49723, 15 hits
PROSITEiView protein in PROSITE
PS50095 PLAT, 15 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLOXH1_MOUSE
AccessioniPrimary (citable) accession number: C8YR32
Secondary accession number(s): Q8BMY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: November 3, 2009
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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