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Protein

Alanine racemase

Gene

Namu_1190

Organism
Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 / Y-104) (Microsphaera multipartita)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Namu_1190)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei58Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei283Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei331Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Namu_1190Imported
OrganismiNakamurella multipartita (strain ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 / Y-104) (Microsphaera multipartita)Imported
Taxonomic identifieri479431 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaNakamurellalesNakamurellaceaeNakamurella
Proteomesi
  • UP000002218 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi479431.Namu_1190

Structurei

3D structure databases

ProteinModelPortaliC8XCN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 389Ala_racemase_CInterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

C8XCN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTAGSTAG PTADPTPRRA GERVAAVVDL AAITANVRTL LALMRGSNPA
60 70 80 90 100
GSVMAVVKAD GYGHGAVAAA QAALAGGATW LGVATPTEAL QLRAAGVDVP
110 120 130 140 150
VLAWLWPPGE RVAPALAAGV QLAVASRAQL DRVLDQAVGA VPDIHVKVDT
160 170 180 190 200
GLGRGGVGPA EIGAVLDAVA AAQRAGRVRV AGLMSHLASA DVPDDPSVPE
210 220 230 240 250
QTATFHRILA AAADRGIDPP LRHLANTAGL IDHPATRFDL VRVGIGGYGL
260 270 280 290 300
NPVATPVPLT PAMTLRATVA LTKRVPAGHG VSYGLTYRTD RETTLALIPL
310 320 330 340 350
GYADGLPRAA SNRGEIWLAG ARRRIAGRVA MDQVVVDCGD DPVAAGDPAI
360 370 380 390
VFGPGEQGEP TARDWADYCG TIDYEIVTRI GPRVPRRNVG EAIP
Length:394
Mass (Da):40,266
Last modified:November 3, 2009 - v1
Checksum:iA1968CDDCF8020A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001737 Genomic DNA Translation: ACV77597.1

Genome annotation databases

EnsemblBacteriaiACV77597; ACV77597; Namu_1190
KEGGinml:Namu_1190

Similar proteinsi

Entry informationi

Entry nameiC8XCN2_NAKMY
AccessioniPrimary (citable) accession number: C8XCN2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: February 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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