UniProtKB - C8VQM2 (C8VQM2_EMENI)
Protein
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
Gene
ANIA_00104
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Functioni
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.UniRule annotationARBA annotation
Catalytic activityi
- α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl β-D-mannosyl phosphate = α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+UniRule annotationARBA annotationEC:2.4.1.258UniRule annotationARBA annotation
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity Source: GO_Central
GO - Biological processi
- protein glycosylation Source: GO_Central
Keywordsi
Molecular function | GlycosyltransferaseUniRule annotationImportedARBA annotation, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Names & Taxonomyi
Protein namesi | Recommended name: Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferaseUniRule annotation (EC:2.4.1.258UniRule annotation)Alternative name(s): Dol-P-Man-dependent alpha(1-3)-mannosyltransferaseUniRule annotation |
Gene namesi | ORF Names:ANIA_00104Imported |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)Imported |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 19 – 37 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 96 – 121 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 141 – 163 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 170 – 199 | HelicalUniRule annotationAdd BLAST | 30 | |
Transmembranei | 205 – 223 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 262 – 285 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 305 – 327 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 334 – 362 | HelicalUniRule annotationAdd BLAST | 29 | |
Transmembranei | 374 – 393 | HelicalUniRule annotationAdd BLAST | 20 |
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotationARBA annotation, MembraneFamily & Domainsi
Sequence similaritiesi
Belongs to the ALG3 family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG2762, Eukaryota |
HOGENOMi | CLU_035382_3_0_1 |
InParanoidi | C8VQM2 |
OMAi | AAHVYIY |
OrthoDBi | 774318at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR007873, Glycosyltransferase_ALG3 |
PANTHERi | PTHR12646, PTHR12646, 1 hit |
Pfami | View protein in Pfam PF05208, ALG3, 1 hit |
i Sequence
Sequence statusi: Complete.
C8VQM2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALTDLVSGL CSNPKHTKWI APILNIADGL LCAFIIWKVP YTEIDWTTYM
60 70 80 90 100
QQVKLYLSGE RDYTLIKGST GPLVYPAAHV YSYSLFHHLT DEGRDIVFGQ
110 120 130 140 150
IIFAFLYLIC LTVVMACYRR VGAPPYLFPL LVLSKRLHSV YMLRLFNDGL
160 170 180 190 200
AALAMWGSIW LFINRKWTPA VVLWSLGLGV KMTLILLVPA VMVVLALSLD
210 220 230 240 250
IGRCIRLAGL ALGIQILLAI PFLKTNPSGY FERAFEFGRQ FMFKWTVNWR
260 270 280 290 300
FVGEDIFLSK GFWAGLIVLH LLILVVLGFT CFLNPSGTSL PDFAGRFLTG
310 320 330 340 350
QHRGIALHPS FIMSALLTSL SVGLLCARSL HYQFFAYLSW ATPFLLWQAG
360 370 380 390 400
YHPILVYALW LVQEWAWNVY PSTNLSSAAV VLLLGAQVLG VLVNRDRAFP
410
SSPPTPKAKQ HVQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BN001308 Genomic DNA Translation: CBF90192.1 |
Genome annotation databases
EnsemblFungii | CBF90192; CBF90192; ANIA_00104 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BN001308 Genomic DNA Translation: CBF90192.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 162425.CADANIAP00002645 |
Genome annotation databases
EnsemblFungii | CBF90192; CBF90192; ANIA_00104 |
Phylogenomic databases
eggNOGi | KOG2762, Eukaryota |
HOGENOMi | CLU_035382_3_0_1 |
InParanoidi | C8VQM2 |
OMAi | AAHVYIY |
OrthoDBi | 774318at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Family and domain databases
InterProi | View protein in InterPro IPR007873, Glycosyltransferase_ALG3 |
PANTHERi | PTHR12646, PTHR12646, 1 hit |
Pfami | View protein in Pfam PF05208, ALG3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C8VQM2_EMENI | |
Accessioni | C8VQM2Primary (citable) accession number: C8VQM2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |