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Entry version 67 (12 Aug 2020)
Sequence version 1 (03 Nov 2009)
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Protein

Nonribosomal peptide synthetase easA

Gene

easA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of emericellamides, secondary metabolites acting as antibiotics (PubMed:18559263). The biosynthesis of emericellamides initiates from the highly reducing polyketide synthase easB which catalyzes the formation of the linear polyketide chain (PubMed:18559263). EasB produces several polyketides that can be further processed by the downstream enzymes (PubMed:18559263). The polyketides are released from easB as linear polyketide carboxylic acids, which are converted to CoA thioesters by the acyl-CoA ligase easD (PubMed:18559263). The substrates are then loaded onto the acyltransferase easC, which shuttles them to the first thiolation (T) domain of the nonribosomal peptide synthetase easA (PubMed:18559263). EasA then performs condensation of the polyketides with one glycine, two alanine, one valine and one leucine residues (PubMed:18559263). A last step of cyclization leads to the production of emericellamides (PubMed:18559263).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Antibiotic biosynthesis

This protein is involved in Antibiotic biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Antibiotic biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthetase easA1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Emericellamide biosynthesis protein A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:easA1 Publication
ORF Names:AN2545
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impairs the production of emerecellamide A, C, D, E and F (PubMed:18559263).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004389691 – 6919Nonribosomal peptide synthetase easAAdd BLAST6919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei54O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1569O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3104O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4188O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei5296O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei6381O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00009275

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C8VPS9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 93Carrier 1PROSITE-ProRule annotation1 PublicationAdd BLAST77
Domaini1531 – 1608Carrier 2PROSITE-ProRule annotation1 PublicationAdd BLAST78
Domaini3067 – 3143Carrier 3PROSITE-ProRule annotation1 PublicationAdd BLAST77
Domaini4151 – 4228Carrier 4PROSITE-ProRule annotation1 PublicationAdd BLAST78
Domaini5260 – 5337Carrier 5PROSITE-ProRule annotation1 PublicationAdd BLAST78
Domaini6344 – 6421Carrier 6PROSITE-ProRule annotation1 PublicationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni123 – 427Epimerization 1Sequence analysis1 PublicationAdd BLAST305
Regioni604 – 981Condensation 1Sequence analysis1 PublicationAdd BLAST378
Regioni1003 – 1394Adenylation 1Sequence analysis1 PublicationAdd BLAST392
Regioni1617 – 2031Epimerization 2Sequence analysis1 PublicationAdd BLAST415
Regioni2072 – 2509Condensation 2Sequence analysis1 PublicationAdd BLAST438
Regioni2541 – 2930Adenylation 2Sequence analysis1 PublicationAdd BLAST390
Regioni3188 – 3599Condensation 3Sequence analysis1 PublicationAdd BLAST412
Regioni3620 – 4018Adenylation 3Sequence analysis1 PublicationAdd BLAST399
Regioni4282 – 4708Condensation 4Sequence analysis1 PublicationAdd BLAST427
Regioni4732 – 5133Adenylation 4Sequence analysis1 PublicationAdd BLAST402
Regioni5380 – 5775Condensation 5Sequence analysis1 PublicationAdd BLAST396
Regioni5824 – 6216Adenylation 5Sequence analysis1 PublicationAdd BLAST393

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The NRPS easA is a multimodular enzymatic assembly that contains 18 domains grouped into five modules corresponding to each of the five amino acid monomers incorporated (PubMed:18559263). The second to the fifth modules contain the three core domains, the condensation (C) domain responsible for catalyzing peptide bond formation, adenylation (A) domain responsible for selecting the amino acid monomer substrate, and the thiolation (T) domain (PubMed:18559263). The first module in the NRPS contains a unique T-E-C-A-T-E structure where (E) domains are epimerization domains (PubMed:18559263). The NRPS does not contain a TE domain at the end of module 5, presumably suggesting that TE is not necessary for the cyclization of the emericellamides (PubMed:18559263).1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1176, Eukaryota
KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_60_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C8VPS9

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPINAHG

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 6 hits
3.30.559.10, 8 hits
3.40.50.12780, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 5 hits
PF00668, Condensation, 8 hits
PF00550, PP-binding, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 6 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 5 hits
PS50075, CARRIER, 6 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C8VPS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQSTFATAG SPNRTVTNNE VVEKDIREIC AEVLRRPVGK IKLDKSFIAQ
60 70 80 90 100
GGDSLLAIKL MARCGEAGYT ITINDMLQAT SIRELCQSVK LAEGSSAPGK
110 120 130 140 150
LSSGPVLDGP AQPAEIRTKP LTEAQKLYAS TKAWDAKVFK LEGGIAESTL
160 170 180 190 200
YAALKLLVSH HPILRANFTT LENNDLGLTY NDTIDAFAHR RIEIPTISTQ
210 220 230 240 250
AEQGYLTVGW EADGKREDGL FAATVFVQKD RDHGTCLARY LRLDFHRAII
260 270 280 290 300
DVSSWDILQR DLDHAVLGKP LARGYPETSF DSWASTHNLS DFTFRRSTPV
310 320 330 340 350
ESTNDERNTN ERQHNRHQND GKIELADVVI LETDAAGLAK LEDESIHSVL
360 370 380 390 400
RTQPEDFIVA ALHIALKGVT RSEETLSFGI ISNGRHSGGP KLSATVGCFD
410 420 430 440 450
NIIRRSVERA EEDGGLGFLR KVKDTRMGFF NVSRISGVED RSRYVLLHMG
460 470 480 490 500
QLGRTTAPIA DTLHELFHQD DFSILPHGCL AFVEPFLEQQ QLKLRLRSRS
510 520 530 540 550
AELGREKLGQ LAGLFRAALK ELIAECEMSE VQGTLSDFPF LKLTYSELDN
560 570 580 590 600
LVSSRLKAVT GDPFRDVEAV FPCGPRQEAF LVAQAVYPDL YQCSFVIKLS
610 620 630 640 650
SEDLNVELDC GRLRDAWVRL VARHPALRTV FIESPNRQGH FDQVVMKQGI
660 670 680 690 700
SSITFLENEG EEAARRLACR RPVTFKSYGQ THQVTFCRIS PSSVYLRLDM
710 720 730 740 750
SHAVVDGLSA LVLMRDLFQL YSKQKLASRV MAYQDFVNYQ SRLPMQESMT
760 770 780 790 800
YWSNYLAGAQ PSHFPLYGDQ LSREDLRTVR SNIQLGSDVL GEFCAWALVL
810 820 830 840 850
RSYTGLEDVC FSYATSGRDV PLKGINNTVG AFLNAVVCRI KLPPTATVPQ
860 870 880 890 900
ALVKARNDFV ESLSHQYYLA LDDAQSGDFA RFKSNTLMSC QRKAATELAG
910 920 930 940 950
SGLAFELVDA ANPNEYDMSI NIQVGHEGLE VMIDYWNSRI GQRTVESVAQ
960 970 980 990 1000
SFRQALLNIV KEEDAVLGEI DISTTQEINQ LREWAKEIPP KADYRIHDKV
1010 1020 1030 1040 1050
YEQRLRRPDA WAVQGWDGDL TYQQLDDTAN QLASYLIRLG VQPETKIPIC
1060 1070 1080 1090 1100
FEKSKWAVIS QLAILKAGGC VVPLGTTQPA SRTRLILKDL QATIILTSGK
1110 1120 1130 1140 1150
FASRFMDLVT HTVVIDEAFM AELPPSEMVP CLATVDNAAF IIYTSGSTGV
1160 1170 1180 1190 1200
PKGVVLPHAS LCTSLEHMGA RFKLSPDTRT VQFSAYTFDI SIQDIYTTWH
1210 1220 1230 1240 1250
YGGCLIILSE EDRISNLAPE MVKYQVNCAG LTSTVAGTIF PQDVPTLKKL
1260 1270 1280 1290 1300
VLLGEAVKQA VVDQWIGHVE VYNAYGPSEC SMQASINRLT PGCNALNIGW
1310 1320 1330 1340 1350
AFAGALWVVD PNDYNRLVPI GAPGELLIEG PLQARGYLNS PEKTAAAFVV
1360 1370 1380 1390 1400
DAAWMIKNGF GSGRRLYRTG DLVQQNPDGS ITYIGRRDTQ IKVRGQRVEV
1410 1420 1430 1440 1450
GEIEHHLLQQ DAVLDAAIIY PKQGPCKDRL VGLLTLRDFF CGKRPGQDII
1460 1470 1480 1490 1500
PIPSGKLSHT KSQLAAASEE LSNHVPEHMV PKIWIPLESM MPQNDSSKLD
1510 1520 1530 1540 1550
RKKLGVWLEA IDTAFLEALT KSSDAGSESR EPETLLERQV QQAWADVLRL
1560 1570 1580 1590 1600
PPTQIPIEHK SFLSVGGDSI TAMHVVSWLR VRGITVAVRD VLESKSVAQL
1610 1620 1630 1640 1650
AQTAEVKDEK TEGHQSLLSP MQKWYFESIA DPELPLKSSG AHRYNSNICL
1660 1670 1680 1690 1700
VPRKLFEYSE LAQAVGALVD RHPILRSRFQ RHNVAGWQQS LHSDGDQPFA
1710 1720 1730 1740 1750
LRHYTVSTSE EAEALIVEAQ GSLDLEQGPV FFVEYIQVED ARNTDLLFMT
1760 1770 1780 1790 1800
AHRLVVDEVS WDIIRRDISV LLEGQQFPTS NPLSFQTWIK LQAQRSQNLE
1810 1820 1830 1840 1850
GIVFRSDLPP ADFKYWGLND GNTYEDETVE EVIFNSHDTN AYFRDANRAL
1860 1870 1880 1890 1900
RTERVEILLA ALLKSFQKTF PNRRLPAVFE INDGRNVGDS GLDFSNTVGN
1910 1920 1930 1940 1950
FECMTPIHIF LDEPHNGLDI VRQTKDARRS AFGRVLSDGQ QAFTDRWVEV
1960 1970 1980 1990 2000
LFQYSEGLAS ETIFETVDLT GPGTSPVGKS TRRGCVFNVN VIAYPDKLRI
2010 2020 2030 2040 2050
RFKFNRNMKY QEKIRDWADS YANAISALGT ELSGASPTLT VTDFPLLHLT
2060 2070 2080 2090 2100
SESLRVLQDE ILPDAGLNCS DVEDIYPCSP IQQGILISQV KSPSEYYIQQ
2110 2120 2130 2140 2150
SFEIIPTTSS GKLDHTRLLA AWQVLINRHP MLRTRFVRSA SGSSERLFDQ
2160 2170 2180 2190 2200
VVLKSCKAEA EHVECTDDDL FRNLAVKATL DERHIDKRIG HKLTIYSTSS
2210 2220 2230 2240 2250
NRTFGNIIIS HALVDASSLM IIQAELAQAY DGKLAPDTIG AAYSEYISHL
2260 2270 2280 2290 2300
QKIPADQALD YWAKRLADAE PCYLRGMTED GMQPATADDS TPRRPMQTVS
2310 2320 2330 2340 2350
IDINCIEKLH SFTETYGVTI ANVFQLVWAM VLAQYTGSPN VSFGYLSSGR
2360 2370 2380 2390 2400
DVPVKDVETM VGPLINMMVT HIKLDMEASA QNTLKQIQEN FFESFNYQRA
2410 2420 2430 2440 2450
PLVEIWHALQ LQGRSLFNTA LSYRHIVSAE KHQLSLALEQ ITGEDPTEYD
2460 2470 2480 2490 2500
VTVSVFASPE KISASLQYSP DFLSYDSANR LLGCVRQGIQ SLVTNGDTHV
2510 2520 2530 2540 2550
GQLNTVTPKD ILQVRAWNDK IPAVDGYCLI HDLFNEQRLL RPNATAVCAW
2560 2570 2580 2590 2600
DGDLTYQQLD EMSNALAHHL VTLGIGPEVM VALCLDKSKF AIIAQLSVLK
2610 2620 2630 2640 2650
AAGVVVSINP KHPTQRLELV LKDINAKVML TSHQYSSQFR NLVPHILHMD
2660 2670 2680 2690 2700
ETLFSALSSQ PQPPSTNVTP NNAAFIIYTS GSTGMPKGVI LTHLSLCSSF
2710 2720 2730 2740 2750
RAHGKIYEMS PSTRSLQFAA YTFDASISDI WGTMSHGGCV CVISEEERMN
2760 2770 2780 2790 2800
NLQGVIEAYG ATHAQVTPTV ASLLDIANIK CLTTLILGGE AVREAMIEEH
2810 2820 2830 2840 2850
AKAAGRVKVL NGYGPSECSI YTTCSAALVQ KKQALNIGRP LVGSVWVIAN
2860 2870 2880 2890 2900
GESICPIGAV GELWVEGPLL ARGYHNDPKK TKAAFVTNPK WAKAIRLEGH
2910 2920 2930 2940 2950
RFYNTGDLVR QSPNGDLIYQ ARKDSQVKVR GQRVEIGEIE YRVKKLLPAV
2960 2970 2980 2990 3000
KSLVASLITP GGNSPNIMIS VAMELSDDFL QRHLLSAPFH EIFLPNAPHL
3010 3020 3030 3040 3050
RDAFSQLHAS LLEVLPSYMV PRLFVPVVHL PQTTSSKLDR RTIKQMLENL
3060 3070 3080 3090 3100
PGDVLFQYSL STSLSVAPST FMEKKLQSLW ATVLNVDQDH VGVQDHFLHC
3110 3120 3130 3140 3150
GGDSFTAMRL VSLANAKDIP ISVADVFRYP KLQEMAAHLE AQMGRRRDVQ
3160 3170 3180 3190 3200
DIPRFGLWKE AQQTEASVSE RELLRVAKLC DVAVHDIEDV YPCTPLQEGL
3210 3220 3230 3240 3250
MAITTQQPGS YIGRWVFRIQ EAVDTNAFKR AWSSLTQKAP ILRTRIAPSQ
3260 3270 3280 3290 3300
SGGLQVVVRE SVAWGGDLNL KQYLDKDLQQ SFGYGQPLVR QALIYSGNKR
3310 3320 3330 3340 3350
YFVLTAHHSV YDGYSLRKLF DAVALLYDGK ELAPTPAFSR FISYIGQQDL
3360 3370 3380 3390 3400
KAAKSFWQSQ IKRKVGAPFP SLHKLSYRPQ PTQKLSSSVE IRPVGGPNTL
3410 3420 3430 3440 3450
ASSLRAAWAL AISAYGGNDV LFGVALSGRS APVPGILDMA APTITTVPVH
3460 3470 3480 3490 3500
VHINPEQTIN QYLTMVHKQS VDMIPFEHTG LQNIRRFVGQ IDLPHLFAVQ
3510 3520 3530 3540 3550
PAQERESSVH GKLLAYEHGH VPELNLDGYA LTVECVTSDI SDIPVTIEAH
3560 3570 3580 3590 3600
FDERMISASQ TNDLLSRFSH IVTQLVTNGR DQTQLKYLDL LSKDEARRLF
3610 3620 3630 3640 3650
QFNQGIPPVK QALVHELVSQ HVSTNPYAPA VCAWDGDLTR EELDRLANKL
3660 3670 3680 3690 3700
ALYLTTLGVI PETMVALCFE KSKWALVANL AVLKAGGAVV PIRADPIQRV
3710 3720 3730 3740 3750
QNILQQTGIT TILASEGFAS ALEGLVPNVI TIGDDLIQSL PSPVTQPIST
3760 3770 3780 3790 3800
VTPSNAAFVI FTSGSTGNPK GVVVEHGAMS TSMQAHGKKF GMNSETRAFN
3810 3820 3830 3840 3850
FAHFTFDISL HDIISTLQFG GCVCMPSERE RVNNMADAMN RMGVNYSFLP
3860 3870 3880 3890 3900
PRVIHTIKPS DVPGLKTLVV GGEAVQPEYL EPWLNGVRVF NAYGPAECSI
3910 3920 3930 3940 3950
AATCNEVANK ADVPNIGRAI AGGLWVVDEN NYNRLLPLGA VGELLIEGPL
3960 3970 3980 3990 4000
LARGYLNDPI KTANAFICNP AWISRYSEHD HCSQRRERRM YRTGDLVRQM
4010 4020 4030 4040 4050
EDGSLIYVGR RDGQVKIRGQ RVEIGEIEHH VTEHPSVVEN VIVYPHCGPA
4060 4070 4080 4090 4100
QLQLVGILTL HGFISSDADE GIQTTPLDQL PHALQQASSV RDHLHSCIPE
4110 4120 4130 4140 4150
YMVPNSWISL AAMPHNSSDK IDRRRLTQWL ETMEVEHFKI LTQSYTEGTT
4160 4170 4180 4190 4200
TPSTSEEKNI QAVWADVLHA SIGKVPMSRP FLAVGGDSVT AMQVVSKCRS
4210 4220 4230 4240 4250
QYSIYVTVRD VLQCESISQL AKKAVIKTTS PNTDTQLSTS SIDQAPAATS
4260 4270 4280 4290 4300
APTAFDINAS DLSKLETDVL PRTGVENLSA IESIYYCSPI QQGILMSQIK
4310 4320 4330 4340 4350
DHTTYQVRQA GEIRAADSSP VDMNRLLRAW QLVVQRHAIL RTFFVPSPSG
4360 4370 4380 4390 4400
RELFYQVVLK RYTPTIPVLQ SCSSDDFLAQ FEGLERPEYA PGQPPYQLTL
4410 4420 4430 4440 4450
AQASTGQVYA QVDVNHVLMD ASSMDLILND LILAYDNMLP DSPAPSYGIY
4460 4470 4480 4490 4500
VSFLQQTFAF DSLNYWTNHL AGAEPSCLPA SSNLDSGKRS LRTVSLEVDN
4510 4520 4530 4540 4550
IKPLQDFRDT HGVTIANITQ LAWATVLSRY LGSRDVSFGY ISNGRDAPID
4560 4570 4580 4590 4600
GIHEMCGPMI NLMVSRVQLA HPGTTVAEAA KQVQHNFLDA FNHQRTSLSD
4610 4620 4630 4640 4650
IQHALHLSER GLFNTTMIYK PKPMMDTHEK RSLVIESLAG EDPTEYDVQV
4660 4670 4680 4690 4700
KIVSDDKSLS LDLEYATTFI DEPSARRLLG SFGRALSSIA ANPDANIDEI
4710 4720 4730 4740 4750
DVIPTGDVEV LHIWNSTVGE TVPGSIHDKI HEQALSQPGA QAVCGWDGEL
4760 4770 4780 4790 4800
TYAELTGMSD RLAHHLRNLG VREEVMVGLC FDKSMWTIVS MIAVLKSGGV
4810 4820 4830 4840 4850
IVPLGVQMPV QRLQHILNEI TAPVVLTMDK HASKLRDITS ANVLTIDGGF
4860 4870 4880 4890 4900
IATLPNPCHP PSESSLTSES AAVVIYTSGS TGTPKGVVLT HGTICTSIES
4910 4920 4930 4940 4950
HGPKLQMGPN TRALQYSAYV FDLSLLDILS TLRFGGCVCV VSEEDRVDTN
4960 4970 4980 4990 5000
SLTTKMEAMA VNFAVLTPTV ASLIDPRTVP TLSTLVLAGE VVPHSAVETW
5010 5020 5030 5040 5050
ASHVTLFNGY GPAESTILAT TNGPIIEKEQ ASSVGTALAG AIWVVDTQDH
5060 5070 5080 5090 5100
NRLVPLGVVG ELLISGPLVA RGYLNDTERT SQSFITDPAF VSKYGFHSWA
5110 5120 5130 5140 5150
GKRIYKTGDL VRQDPTDGSI MFVGRADGQI KIRGQRVEVG EIEYWLRQHF
5160 5170 5180 5190 5200
DTQTVAVDVI GASTGDVALV AAIELRKDRS SNECVFLDVN HQLRESFLQL
5210 5220 5230 5240 5250
QAALLKALPS YMVPSKYIPI KNMPNTASGK LDRRALRTLI GGLKEEQLAQ
5260 5270 5280 5290 5300
YSLADGGNVA LSTETERRLA RVWVAALNTS KEFGANAHFF RVGGDSVTAM
5310 5320 5330 5340 5350
RLVALARTAQ PPILLSVSDV FKHPVLSDMA NTIANSESTE NCQYDNDVPP
5360 5370 5380 5390 5400
FLLLPYPQHE RQARLQEIAS QCKVEVDVIE DAYPCTPLQQ GLMAITAQHP
5410 5420 5430 5440 5450
QAYISRWVFR LEDTIDESRF CQAWRTLVEL NPILRTRIIQ DPKAGGMQVV
5460 5470 5480 5490 5500
LQQQITWNNV LSELPSYIAE DSAKPMGFGD PLVRLAVVTS RQARFFVWTA
5510 5520 5530 5540 5550
HHSTYDGWTA RKLMEAAFAL YSNNPAPSFH PFTRFVQYLQ SNSAEETRDY
5560 5570 5580 5590 5600
WKSQLEGGIG PSFPGSPKNG SPRKLRIQSC RIPANNSNDF TLSTLLRATW
5610 5620 5630 5640 5650
ALILSQETGS QIVGFPTALS GRTAPVDGIL DVLGPTITTV PIRVSVDPAQ
5660 5670 5680 5690 5700
SLSAYLASIQ QQATEMLPFE HAGLHNISRM TSLPLNFQHL FVVQPAVDRL
5710 5720 5730 5740 5750
DQANSGFQGL TPVPFETYGF HNYPLVIECS TNMTDTDSAV DLQLQFDPAV
5760 5770 5780 5790 5800
LSVEKATTIL ERFTHVFGQL QSAANEATCE VLVSDVIFMT PEDLGRIQKW
5810 5820 5830 5840 5850
NHFDERMTMA DGCIHDLVHH QLLSCPDAQA VHAFDGHLTY RELHRLATRL
5860 5870 5880 5890 5900
AYHLEGLGVG PQVPVATIFE KTKWVVVTYL AVLKAGGTIV PVNHQHPKQR
5910 5920 5930 5940 5950
MQALVQSIGT RVILTSQDPG RLQGLVTGPV LKVDQDFFTQ LPDSDNPHPV
5960 5970 5980 5990 6000
VQATDSAFII FTSGSTGTSK AVVLQHGAIV SSMVQGHGSL YASPDTRAIQ
6010 6020 6030 6040 6050
FSALNFDISI AEIFTTLSFG GCVCVISEDD RVSRLAEAME EAAVNFAILT
6060 6070 6080 6090 6100
PTVASLLKPE QVPSLRRLLL VGEALRPEVA EPWSSSHVEL HNAYGPAESS
6110 6120 6130 6140 6150
ILTTFSQRIR DPVQAPNIGF PLAHSNLFVV DPSNYHNLLP VGMVGELLIE
6160 6170 6180 6190 6200
GPLLAREYLG DAKKTAEAFV TDPAWLQQYD LGPVSGRRFY RTGDLVQQKL
6210 6220 6230 6240 6250
DGSFIYIGRR DTQVKIHGQR VEIGEIEFWV KNKLPDVREV VAGLFKPIYE
6260 6270 6280 6290 6300
EDEPLLAVAM EVPSSSVESS GLLSLSDELR EAFGELRRNL LTVVPSYMVP
6310 6320 6330 6340 6350
QLYLPFAKLP LTDSGKLNRR ATWEMIHSCG SWSQYFLVDD IKAEPATVTE
6360 6370 6380 6390 6400
RLLQSLWATV LKVPASSIGA KDDFFRSGGD SISAMRLVAS AREDAHISLK
6410 6420 6430 6440 6450
VADVFRHPIL SDMATLIDRK TTVTKPAYCP FSTMTDDYAI RDSIKPLLSV
6460 6470 6480 6490 6500
PSEIIDVAPT TDLQSLSIAT SLRPSRDLMA YVSIDGIGSP NFARWRASCL
6510 6520 6530 6540 6550
EVVKKHDILR TAYVVYKNQL LQVVLRDYAP AVTHYQTDQS IEEFTKEFIA
6560 6570 6580 6590 6600
HDMHRPPQLG YPFLEFAIIC SPVANRHRVL FRLSHAEYDA ISLSYFVNSL
6610 6620 6630 6640 6650
REIYQRQSTT EYVGFPQYIS SLANQDTWSS REYWRSLLKG CTMPAISSSS
6660 6670 6680 6690 6700
QPRRLPSRQV YHDSRRVSFK TLPAGITLST IVRSAWALTL GQHVGNPDVL
6710 6720 6730 6740 6750
FGEVVSGRNG DPIAERAAGC CANLVPVRAT IHPAWTTHDL LRSVQQQLVS
6760 6770 6780 6790 6800
RLPHESLGFR DLMRNCTDMP VGTVFTSLLN HLDQASEWTL DLDDGKYNVS
6810 6820 6830 6840 6850
VAKTEGAGDV SDVSVTSTAS TDYVEIAMAY LEDGVTVEVA EKLLSQLCET
6860 6870 6880 6890 6900
VDAFMNGALD AELPTVDCVS ELNAQGVNEA PKFEGDLVDA SLVAFELQKR
6910
GHEVTVDEVV DRGLSLSGV
Length:6,919
Mass (Da):764,631
Last modified:November 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i001A0679156709E6
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAA64650 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AACD01000043 Genomic DNA Translation: EAA64650.1 Sequence problems.
BN001307 Genomic DNA Translation: CBF87069.1

NCBI Reference Sequences

More...
RefSeqi
XP_660149.1, XM_655057.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CBF87069; CBF87069; ANIA_02545
EAA64650; EAA64650; AN2545.2

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2875600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN2545.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000043 Genomic DNA Translation: EAA64650.1 Sequence problems.
BN001307 Genomic DNA Translation: CBF87069.1
RefSeqiXP_660149.1, XM_655057.1

3D structure databases

SMRiC8VPS9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00009275

Genome annotation databases

EnsemblFungiiCBF87069; CBF87069; ANIA_02545
EAA64650; EAA64650; AN2545.2
GeneIDi2875600
KEGGiani:AN2545.2

Phylogenomic databases

eggNOGiKOG1176, Eukaryota
KOG1178, Eukaryota
HOGENOMiCLU_000022_60_0_1
InParanoidiC8VPS9
OMAiLPINAHG
OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 6 hits
3.30.559.10, 8 hits
3.40.50.12780, 5 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 5 hits
PF00668, Condensation, 8 hits
PF00550, PP-binding, 6 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 6 hits
SUPFAMiSSF47336, SSF47336, 6 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 5 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 5 hits
PS50075, CARRIER, 6 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEASA_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C8VPS9
Secondary accession number(s): Q5BA85
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: November 3, 2009
Last modified: August 12, 2020
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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