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Entry version 60 (02 Dec 2020)
Sequence version 1 (03 Nov 2009)
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Protein

Purine-cytosine permease fcyB

Gene

fcyB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This permease has a broad specificity towards purines, and also transports cytosine, but neither uracil nor thymine. Contributes very little in purine uptake. Its major role may be the uptake of cytosine.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7 µM for adenine1 Publication
  2. KM=11.5 µM for guanine1 Publication
  3. KM=20 µM for hypoxanthine1 Publication
  4. KM=20 µM for cytosine1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    • purine nucleobase transport Source: AspGD

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processTransport

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.39.2.4, the nucleobase:cation symporter-1 (ncs1) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Purine-cytosine permease fcyB
    Short name:
    PCP fcyB
    Alternative name(s):
    Cytosine/purine transport protein fcyB
    Fluorocytosine resistance protein fcyB
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:fcyB
    ORF Names:AN10767
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I
    • UP000005890 Componenti: Unassembled WGS sequence

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 72CytoplasmicSequence analysisAdd BLAST72
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
    Topological domaini94 – 104ExtracellularSequence analysisAdd BLAST11
    Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
    Topological domaini126 – 147CytoplasmicSequence analysisAdd BLAST22
    Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
    Topological domaini169 – 177ExtracellularSequence analysis9
    Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
    Topological domaini199 – 200CytoplasmicSequence analysis2
    Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
    Topological domaini222 – 243ExtracellularSequence analysisAdd BLAST22
    Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
    Topological domaini265 – 278CytoplasmicSequence analysisAdd BLAST14
    Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
    Topological domaini300 – 323ExtracellularSequence analysisAdd BLAST24
    Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
    Topological domaini345 – 374CytoplasmicSequence analysisAdd BLAST30
    Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
    Topological domaini396 – 404ExtracellularSequence analysis9
    Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
    Topological domaini426 – 442CytoplasmicSequence analysisAdd BLAST17
    Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
    Topological domaini464 – 477ExtracellularSequence analysisAdd BLAST14
    Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
    Topological domaini499 – 508CytoplasmicSequence analysis10

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004131731 – 508Purine-cytosine permease fcyBAdd BLAST508

    Keywords - PTMi

    Phosphoprotein

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Highly induced during germination and drops to a low constant level throughout vegetative development. Repressed by ammonium. Down-regulated by endocytosis in responde to ammonia or the presence of cytosine.1 Publication

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    162425.CADANIAP00007001

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502QQ8Y, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_019836_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    C8V329

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ASWQIAF

    Database of Orthologous Groups

    More...
    OrthoDBi
    488201at2759

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.4160.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001248, Pur-cyt_permease
    IPR026030, Pur-cyt_permease_Fcy2/21/22
    IPR038271, Pur-cyt_permease_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR31806, PTHR31806, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02133, Transp_cyt_pur, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF002744, Pur-cyt_permease, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    C8V329-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAGAFDFDLE KNPPVVQSTA DNSSDGAVPG ETFTYGDSTY AKIQRLAAEL
    60 70 80 90 100
    NIEQRGIERV PAAEQTDTSV FNIGSMWLAA NMVVSSFAIG VLGKSVYSLG
    110 120 130 140 150
    FVDAILTVLF FNLLGIMTVC FFSCFGPFGL RQMVFSRLWF GWYVTKGFAV
    160 170 180 190 200
    LNILACLGWS AANAIVGAQM LHAVNSDVPG FAAILIISIC TLLVTFAGYK
    210 220 230 240 250
    VVHLYEYWSW IPTFIVFMII LGTFAHSGDF QNIPMGVGTS EMGSVLSFGS
    260 270 280 290 300
    AVYGFATGWT SYAADYTVYQ PANRSKRKIF LSTWLGLIVP LLFVEMLGVA
    310 320 330 340 350
    VMTATDIKGS KYDVGYATSG NGGLIAAVLQ PLGGFGDFCL VILALSIVAN
    360 370 380 390 400
    NCPNFYSVAL TVQVLSRYAQ RVPRFIWTLF GTGVSIAIAI PGYSHFETVL
    410 420 430 440 450
    ENFMNFIAYW LAIYSAIAIM DHFVFKRGFS GYVVENFDKR EKLPVGIAAT
    460 470 480 490 500
    IAFGFGVAGM ITGMSQPWYV GPIARHAAGG DVGFELGFAF AAFSYLCLRP

    FEIKFFGR
    Length:508
    Mass (Da):55,197
    Last modified:November 3, 2009 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84E1E168D6CF3D4A
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence EAA57658 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN6017 has been split into 2 genes: AN10765 and AN10767.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    EU502921 mRNA Translation: ACA81792.1
    AACD01000103 Genomic DNA Translation: EAA57658.1 Sequence problems.
    BN001301 Genomic DNA Translation: CBF70354.1

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_663621.1, XM_658529.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    CBF70354; CBF70354; ANIA_10767
    EAA57658; EAA57658; AN6017.2

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2870983

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ani:AN6017.2

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    EU502921 mRNA Translation: ACA81792.1
    AACD01000103 Genomic DNA Translation: EAA57658.1 Sequence problems.
    BN001301 Genomic DNA Translation: CBF70354.1
    RefSeqiXP_663621.1, XM_658529.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00007001

    Protein family/group databases

    TCDBi2.A.39.2.4, the nucleobase:cation symporter-1 (ncs1) family

    Genome annotation databases

    EnsemblFungiiCBF70354; CBF70354; ANIA_10767
    EAA57658; EAA57658; AN6017.2
    GeneIDi2870983
    KEGGiani:AN6017.2

    Phylogenomic databases

    eggNOGiENOG502QQ8Y, Eukaryota
    HOGENOMiCLU_019836_0_0_1
    InParanoidiC8V329
    OMAiASWQIAF
    OrthoDBi488201at2759

    Family and domain databases

    Gene3Di1.10.4160.10, 1 hit
    InterProiView protein in InterPro
    IPR001248, Pur-cyt_permease
    IPR026030, Pur-cyt_permease_Fcy2/21/22
    IPR038271, Pur-cyt_permease_sf
    PANTHERiPTHR31806, PTHR31806, 1 hit
    PfamiView protein in Pfam
    PF02133, Transp_cyt_pur, 1 hit
    PIRSFiPIRSF002744, Pur-cyt_permease, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCY2_EMENI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C8V329
    Secondary accession number(s): B1PXD0, Q5B0B3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: November 3, 2009
    Last modified: December 2, 2020
    This is version 60 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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