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Protein

Lipoate--protein ligase

Gene

lplA

Organism
Cardiobacterium hominis (strain ATCC 15826 / DSM 8339 / NCTC 10426 / 6573)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate.SAAS annotation

Pathwayi: protein lipoylation via exogenous pathway

This protein is involved in step 2 of the subpathway that synthesizes protein N(6)-(lipoyl)lysine from lipoate.SAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Lipoate--protein ligase (lplA)
This subpathway is part of the pathway protein lipoylation via exogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from lipoate, the pathway protein lipoylation via exogenous pathway and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported, TransferaseImported
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00537;UER00595

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoate--protein ligaseSAAS annotation (EC:6.3.1.20SAAS annotation)
Gene namesi
Name:lplAImported
ORF Names:HMPREF0198_0777Imported
OrganismiCardiobacterium hominis (strain ATCC 15826 / DSM 8339 / NCTC 10426 / 6573)Imported
Taxonomic identifieri638300 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeCardiobacterium
Proteomesi
  • UP000004870 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi638300.HMPREF0198_0777

Structurei

3D structure databases

ProteinModelPortaliC8N8F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 209BPL/LPL catalyticInterPro annotationAdd BLAST183

Phylogenomic databases

eggNOGiENOG4107RMF Bacteria
COG0095 LUCA
OrthoDBiPOG091H03KP

Family and domain databases

InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR019491 Lipoate_protein_ligase_C
IPR004562 LipoylTrfase_LipoateP_Ligase
PANTHERiPTHR12561 PTHR12561, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PF10437 Lip_prot_lig_C, 1 hit
TIGRFAMsiTIGR00545 lipoyltrans, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

C8N8F0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFVDNQEIT DPRTNIALET YLVENRLCDE PLLLFYINEP SIIIGRNQNT
60 70 80 90 100
VEEVNQAYVD AHGIHVVRRM SGGGAVYHDL GNFSFCFIQD ENSLSRDFSV
110 120 130 140 150
FTKPVIEALH QMGVAGAKLE GRNDLLIDGK KFSGNAMYVK NGRMTAHGTI
160 170 180 190 200
LFDADLDAVT QALKPRADKI ESKGIKSVRS RVTNIKPFVA PEYKSLTTRQ
210 220 230 240 250
FRDALLLYIF GVKDRAQVPE YFLTDADWEK IAQIRAERFA NWDWNYGKSP
260 270 280 290 300
AFSSERYCKF PQGAVDFRFS VERGVVQSLK IYGDFFGMGD IADVEKWLTG
310 320 330
IPYRREAVEL AFKQFDARHY FGGIEAEALV DLLVG
Length:335
Mass (Da):38,028
Last modified:November 3, 2009 - v1
Checksum:iB4645FD0A70A0CB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACKY01000034 Genomic DNA Translation: EEV89103.1
RefSeqiWP_004140177.1, NZ_GG694025.1

Genome annotation databases

EnsemblBacteriaiEEV89103; EEV89103; HMPREF0198_0777

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACKY01000034 Genomic DNA Translation: EEV89103.1
RefSeqiWP_004140177.1, NZ_GG694025.1

3D structure databases

ProteinModelPortaliC8N8F0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi638300.HMPREF0198_0777

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEEV89103; EEV89103; HMPREF0198_0777

Phylogenomic databases

eggNOGiENOG4107RMF Bacteria
COG0095 LUCA
OrthoDBiPOG091H03KP

Enzyme and pathway databases

UniPathwayi
UPA00537;UER00595

Family and domain databases

InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR019491 Lipoate_protein_ligase_C
IPR004562 LipoylTrfase_LipoateP_Ligase
PANTHERiPTHR12561 PTHR12561, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PF10437 Lip_prot_lig_C, 1 hit
TIGRFAMsiTIGR00545 lipoyltrans, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC8N8F0_CARH6
AccessioniPrimary (citable) accession number: C8N8F0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 7, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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