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Protein
Submitted name:

Bone morphogenetic protein 2

Gene

BMP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Bone morphogenetic protein 2Imported
Gene namesi
Name:BMP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000125845.6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25379

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501011076824 – 396Sequence analysisAdd BLAST373

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiC8C060

Expressioni

Gene expression databases

BgeeiENSG00000125845 Expressed in 186 organ(s), highest expression level in thyroid gland
ExpressionAtlasiC8C060 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiC8C060
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini279 – 396TGF_BETA_2InterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
KOiK21283
OMAiQGVSKRH
OrthoDBiEOG091G0K7Z

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

C8C060-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL
60 70 80 90 100
SEFELRLLSM FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE
110 120 130 140 150
RAASRANTVR SFHHEESLEE LPETSGKTTR RFFFNLSSIP TEEFITSAEL
160 170 180 190 200
QVFREQMQDA LGNNSSFHHR INIYEIIKPA TANSKFPVTR LLDTRLVNQN
210 220 230 240 250
ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS KRHVRISRSL
260 270 280 290 300
HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP
310 320 330 340 350
LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN
360 370 380 390
SVNSKIPKAC CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR
Length:396
Mass (Da):44,702
Last modified:October 13, 2009 - v1
Checksum:i20653A3987B25E60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ335529 Genomic DNA Translation: ACV32585.1
GQ335531 Genomic DNA Translation: ACV32587.1
RefSeqiNP_001191.1, NM_001200.3
UniGeneiHs.73853

Genome annotation databases

GeneIDi650
KEGGihsa:650

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ335529 Genomic DNA Translation: ACV32585.1
GQ335531 Genomic DNA Translation: ACV32587.1
RefSeqiNP_001191.1, NM_001200.3
UniGeneiHs.73853

3D structure databases

SMRiC8C060
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiC8C060

Protocols and materials databases

DNASUi650
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi650
KEGGihsa:650

Organism-specific databases

CTDi650
EuPathDBiHostDB:ENSG00000125845.6
PharmGKBiPA25379

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
KOiK21283
OMAiQGVSKRH
OrthoDBiEOG091G0K7Z

Miscellaneous databases

ChiTaRSiBMP2 human
GenomeRNAii650

Gene expression databases

BgeeiENSG00000125845 Expressed in 186 organ(s), highest expression level in thyroid gland
ExpressionAtlasiC8C060 baseline and differential

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC8C060_HUMAN
AccessioniPrimary (citable) accession number: C8C060
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 12, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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