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Entry version 49 (02 Jun 2021)
Sequence version 1 (13 Oct 2009)
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Protein

Phosphatidylethanolamine N-methyltransferase

Gene

CHO2

Organism
Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) (Fusarium solani subsp. pisi)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in the pathway phosphatidylcholine biosynthesis, which is part of Phospholipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00753

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylethanolamine N-methyltransferaseUniRule annotation (EC:2.1.1.17UniRule annotation)
Short name:
PE methyltransferaseUniRule annotation
Short name:
PEAMTUniRule annotation
Short name:
PEMTUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHO2
ORF Names:NECHADRAFT_76384
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) (Fusarium solani subsp. pisi)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri660122 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complexFusarium vanettenii
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005206 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 87LumenalUniRule annotationAdd BLAST87
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei88 – 108HelicalUniRule annotationAdd BLAST21
Topological domaini109 – 113CytoplasmicUniRule annotation5
Transmembranei114 – 134HelicalUniRule annotationAdd BLAST21
Topological domaini135 – 200LumenalUniRule annotationAdd BLAST66
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Topological domaini222 – 228CytoplasmicUniRule annotation7
Transmembranei229 – 249HelicalUniRule annotationAdd BLAST21
Topological domaini250 – 278LumenalUniRule annotationAdd BLAST29
Transmembranei279 – 299HelicalUniRule annotationAdd BLAST21
Topological domaini300 – 305CytoplasmicUniRule annotation6
Transmembranei306 – 326HelicalUniRule annotationAdd BLAST21
Topological domaini327 – 393LumenalUniRule annotationAdd BLAST67
Transmembranei394 – 414HelicalUniRule annotationAdd BLAST21
Topological domaini415 – 421CytoplasmicUniRule annotation7
Transmembranei422 – 442HelicalUniRule annotationAdd BLAST21
Topological domaini443 – 468LumenalUniRule annotationAdd BLAST26
Transmembranei469 – 489HelicalUniRule annotationAdd BLAST21
Topological domaini490 – 501CytoplasmicUniRule annotationAdd BLAST12
Transmembranei502 – 522HelicalUniRule annotationAdd BLAST21
Topological domaini523 – 577LumenalUniRule annotationAdd BLAST55
Transmembranei578 – 598HelicalUniRule annotationAdd BLAST21
Topological domaini599 – 975CytoplasmicUniRule annotationAdd BLAST377

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004058981 – 975Phosphatidylethanolamine N-methyltransferaseAdd BLAST975

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
C7Z7C3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
140110.NechaP76384

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C7Z7C3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 58DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 58Polar residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRGH, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005987_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C7Z7C3

Database of Orthologous Groups

More...
OrthoDBi
170424at2759

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03217, PEMT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007318, Phopholipid_MeTrfase
IPR016219, Phosphatid-EA_MeTrfase_fun

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04191, PEMT, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000383, PEAMT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51598, SAM_CHO2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C7Z7C3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAADLPST GPGLRLRQPG VEPLVDQDKL PSQPGHSRES SDANADANVS
60 70 80 90 100
SDKASKTYGR TPDGTVFIVP TTHDMVSQLL DPRQPKNFSD AIVLTILGLH
110 120 130 140 150
ILAAYFLPSS YKRIVFAFVF LFWRACYNIG IGVLLQIQSN HRRLVTWARR
160 170 180 190 200
WKLFENPATG KNPRPWLYNL LKNELETKIE EDYEFEKAPI EYNTWLVFRR
210 220 230 240 250
VVDLILMCDF VSYCLFAIVC GHSPEGENPL IGFSRWAIGI SLIGFNLWVK
260 270 280 290 300
LDAHRVVKDF AWYWGDFFYL IDQDLTFDGV FEMAPHPMYS IGYAGYYGIS
310 320 330 340 350
MMAASYEVLF ISILAHLAQF AFLVIVENPH IEKTYNPPPP RKRTASESQG
360 370 380 390 400
DVVPADVKSL EGAFDQQTLA PTHKESPAPV HNLVGLNNID LFRVPDFTVI
410 420 430 440 450
VLPSYVAVLT FVTPETPVWQ AIFVLHALAW RVWYHLGLGL ILDKQSKTKM
460 470 480 490 500
WTRHFLKFGE SAGEAWRQWK GLHHISMIMC NTAFIAACWK MYSPPEDWAY
510 520 530 540 550
GLVMLKHVLG AGLVALQLWT AFSVYDSLGE FGWFCGDFFF DQQAKLTYKS
560 570 580 590 600
IYRFLNNPDR FFGTAGVWGA ALITWSRSIF LMALVTQILT VFYISYIERP
610 620 630 640 650
HMQKIYGRSL RREAGLTKFI KRSLPPPVKG WQESVDKVLD DTTQFVEDFL
660 670 680 690 700
DTARPKFAAG VKTIVRDTSA LFNMAPARLT ITRIAPDLQG HDPKLYSLSV
710 720 730 740 750
QGTPSMGTSI DDKFTGKESL TGRFPKQIKT MIYEYGAPLR VKWRAPAGHS
760 770 780 790 800
KKDWIGLYMV TDNRSRETTE VPSLGRWAPT NAGVYDSLTA DVSIAVEEHP
810 820 830 840 850
VSTTEATEID MVEGEVEFRG DKLWWTQGVF EFRYHHDGHH TALSISEPFE
860 870 880 890 900
IRISKFDEED VDVGAKGLYE QAVESALLPV VQNCLDRDPD IAPNQPEEPF
910 920 930 940 950
GGHVERDTKY AKRIVYAIRE MFGIEFAPPV VAADGSVRKL AWRVSNAKEV
960 970
LAPYSMSRSR GTTTPAIQDF PAEKA
Length:975
Mass (Da):110,272
Last modified:October 13, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i855B2630F7270997
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GG698910 Genomic DNA Translation: EEU40846.1

NCBI Reference Sequences

More...
RefSeqi
XP_003046559.1, XM_003046513.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
NechaT76384; NechaP76384; NechaG76384

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9668269

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nhe:NECHADRAFT_76384

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698910 Genomic DNA Translation: EEU40846.1
RefSeqiXP_003046559.1, XM_003046513.1

3D structure databases

SMRiC7Z7C3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi140110.NechaP76384

Proteomic databases

PRIDEiC7Z7C3

Genome annotation databases

EnsemblFungiiNechaT76384; NechaP76384; NechaG76384
GeneIDi9668269
KEGGinhe:NECHADRAFT_76384

Phylogenomic databases

eggNOGiENOG502QRGH, Eukaryota
HOGENOMiCLU_005987_0_1_1
InParanoidiC7Z7C3
OrthoDBi170424at2759

Enzyme and pathway databases

UniPathwayiUPA00753

Family and domain databases

HAMAPiMF_03217, PEMT, 1 hit
InterProiView protein in InterPro
IPR007318, Phopholipid_MeTrfase
IPR016219, Phosphatid-EA_MeTrfase_fun
PfamiView protein in Pfam
PF04191, PEMT, 2 hits
PIRSFiPIRSF000383, PEAMT, 1 hit
PROSITEiView protein in PROSITE
PS51598, SAM_CHO2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHO2_FUSV7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C7Z7C3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: October 13, 2009
Last modified: June 2, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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