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Entry version 69 (05 Jun 2019)
Sequence version 1 (13 Oct 2009)
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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:103013 Cacna1c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei158 – 175HelicalSequence analysisAdd BLAST18
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei227 – 245HelicalSequence analysisAdd BLAST19
Transmembranei298 – 320HelicalSequence analysisAdd BLAST23
Transmembranei379 – 400HelicalSequence analysisAdd BLAST22
Transmembranei412 – 434HelicalSequence analysisAdd BLAST23
Transmembranei580 – 598HelicalSequence analysisAdd BLAST19
Transmembranei706 – 728HelicalSequence analysisAdd BLAST23
Transmembranei782 – 808HelicalSequence analysisAdd BLAST27
Transmembranei956 – 975HelicalSequence analysisAdd BLAST20
Transmembranei987 – 1009HelicalSequence analysisAdd BLAST23
Transmembranei1029 – 1052HelicalSequence analysisAdd BLAST24
Transmembranei1073 – 1106HelicalSequence analysisAdd BLAST34
Transmembranei1198 – 1224HelicalSequence analysisAdd BLAST27
Transmembranei1275 – 1292HelicalSequence analysisAdd BLAST18
Transmembranei1304 – 1326HelicalSequence analysisAdd BLAST23
Transmembranei1414 – 1437HelicalSequence analysisAdd BLAST24
Transmembranei1507 – 1531HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
C7TQ58 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1665 – 1699Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni103 – 128DisorderedSequence analysisAdd BLAST26
Regioni478 – 501DisorderedSequence analysisAdd BLAST24
Regioni819 – 916DisorderedSequence analysisAdd BLAST98
Regioni1787 – 1828DisorderedSequence analysisAdd BLAST42
Regioni1995 – 2021DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1626 – 1646Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi486 – 501PolyampholyteSequence analysisAdd BLAST16
Compositional biasi819 – 864PolyampholyteSequence analysisAdd BLAST46
Compositional biasi881 – 897PolyampholyteSequence analysisAdd BLAST17
Compositional biasi2002 – 2017Pro-richSequence analysisAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231529

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005451 VDCC_L_a1csu
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01635 LVDCCALPHA1C

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062 Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C7TQ58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRAFVQPST PPYQPLSSHS SEETERKFKG KVVHEAQLNC FYISPGGSNY
60 70 80 90 100
GSPRPAHANM NANAAAGLAP EHIPTPGAAL SWQAAIDAAR QAKLMGSAGN
110 120 130 140 150
ATISTVSSTQ RKRQQYGKPK KQGGTTATRP PRALLCLTLK NPIRRACISI
160 170 180 190 200
VEWKPFEIII LLTIFANCVA LAIYIPFPED DSNATNSNLE RVEYLFLIIF
210 220 230 240 250
TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA ILEQATKADG
260 270 280 290 300
ANALGGKGAG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH
310 320 330 340 350
IALLVLFVII IYAIIGLELF MGKMHKTCYN QEGIIDVPAE EDPSPCALET
360 370 380 390 400
GHGRQCQNGT VCKPGWDGPK HGITNFDNFA FAMLTVFQCI TMEGWTDVLY
410 420 430 440 450
WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV LGVLSGEFSK EREKAKARGD
460 470 480 490 500
FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK PRNRGAPAGL
510 520 530 540 550
HDQKKGKFAW FSHSTETHMS MPTSETESVN TENVAGGDIE GENCGARLAH
560 570 580 590 600
RISKSKFSRY WRRWNRFCRR KCRAAVKSNV FYWLVIFLVF LNTLTIASEH
610 620 630 640 650
YNQPHWLTEV QDTANKALLA LFTAEMLLKM YSLGLQAYFV SLFNRFDCFI
660 670 680 690 700
VCGGILETIL VETKIMSPLG ISVLRCVRLL RIFKITRYWN SLSNLVASLL
710 720 730 740 750
NSVRSIASLL LLLFLFIIIF SLLGMQLFGG KFNFDEMQTR RSTFDNFPQS
760 770 780 790 800
LLTVFQILTG EDWNSVMYDG IMAYGGPSFP GMLVCIYFII LFICGNYILL
810 820 830 840 850
NVFLAIAVDN LADAESLTSA QKEEEEEKER KKLARTASPE KKQEVMEKPA
860 870 880 890 900
VEESKEEKIE LKSITADGES PPTTKINMDD LQPSENEDKS PHSNPDTAGE
910 920 930 940 950
EDEEEPEMPV GPRPRPLSEL HLKEKAVPMP EASAFFIFSP NNRFRLQCHR
960 970 980 990 1000
IVNDTIFTNL ILFFILLSSI SLAAEDPVQH TSFRNHILFY FDIVFTTIFT
1010 1020 1030 1040 1050
IEIALKMTAY GAFLHKGSFC RNYFNILDLL VVSVSLISFG IQSSAINVVK
1060 1070 1080 1090 1100
ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIVIV TTLLQFMFAC
1110 1120 1130 1140 1150
IGVQLFKGKL YTCSDSSKQT EAECKGNYIT YKDGEVDHPI IQPRSWENSK
1160 1170 1180 1190 1200
FDFDNVLAAM MALFTVSTFE GWPELLYRSI DSHTEDKGPI YNYRVEISIF
1210 1220 1230 1240 1250
FIIYIIIIAF FMMNIFVGFV IVTFQEQGEQ EYKNCELDKN QRQCVEYALK
1260 1270 1280 1290 1300
ARPLRRYIPK NQHQYKVWYV VNSTYFEYLM FVLILLNTIC LAMQHYGQSC
1310 1320 1330 1340 1350
LFKIAMNILN MLFTGLFTVE MILKLIAFKP KGYFSDPWNV FDFLIVIGSI
1360 1370 1380 1390 1400
IDVILSETNP AEHTQCSPSM SAEENSRISI TFFRLFRVMR LVKLLSRGEG
1410 1420 1430 1440 1450
IRTLLWTFIK SFQALPYVAL LIVMLFFIYA VIGMQVFGKI ALNDTTEINR
1460 1470 1480 1490 1500
NNNFQTFPQA VLLLFRCATG EAWQDIMLAC MPGKKCAPES EPSNSTEGET
1510 1520 1530 1540 1550
PCGSSFAVFY FISFYMLCAF LIINLFVAVI MDNFDYLTRD WSILGPHHLD
1560 1570 1580 1590 1600
EFKRIWAEYD PEAKGRIKHL DVVTLLRRIQ PPLGFGKLCP HRVACKRLVS
1610 1620 1630 1640 1650
MNMPLNSDGT VMFNATLFAL VRTALRIKTE GNLEQANEEL RAIIKKIWKR
1660 1670 1680 1690 1700
TSMKLLDQVV PPAGDDEVTV GKFYATFLIQ EYFRKFKKRK EQGLVGKPSQ
1710 1720 1730 1740 1750
RNALSLQAGL RTLHDIGPEI RRAISGDLTA EEELDKAMKE AVSAASEDDI
1760 1770 1780 1790 1800
FRRAGGLFGN HVTYYQSDSR GNFPQTFATQ RPLHINKTGN NQADTESPSH
1810 1820 1830 1840 1850
EKLVDSTFTP SSYSSTGSNA NINNANNTAL GRFPHPAGYS STVSTVEGHG
1860 1870 1880 1890 1900
PPLSPAVRVQ EAAWKLSSKR CHSRESQGAT VNQEIFPDET RSVRMSEEAE
1910 1920 1930 1940 1950
YCSEPSLLST DMFSYQEDEH RQLTCPEEDK REIQPSPKRS FLRSASLGRR
1960 1970 1980 1990 2000
ASFHLECLKR QKDQGGDISQ KTALPLHLVH HQALAVAGLS PLLQRSHSPT
2010 2020 2030 2040 2050
TFPRPCPTPP VTPGSRGRPL RPIPTLRLEG AESSEKLNSS FPSIHCSSWS
2060 2070 2080 2090 2100
EETTACSGSS SMARRARPVS LTVPSQAGAP GRQFHGSASS LVEAVLISEG
2110 2120 2130 2140 2150
LGQFAQDPKF IEVTTQELAD ACDMTIEEME NAADNILSGG AQQSPNGTLL
2160 2170 2180 2190
PFVNCRDPGQ DRAVAPEDES CAYALGRGRS EEALADSRSY VSNL
Length:2,194
Mass (Da):246,283
Last modified:October 13, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CDE5C48B042923E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FM872410 mRNA Translation: CAS06713.1

NCBI Reference Sequences

More...
RefSeqi
NP_001242927.1, NM_001255998.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12288

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM872410 mRNA Translation: CAS06713.1
RefSeqiNP_001242927.1, NM_001255998.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12288

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
775
MGIiMGI:103013 Cacna1c

Phylogenomic databases

HOGENOMiHOG000231529
OrthoDBi172471at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cacna1c mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiC7TQ58 MM

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005451 VDCC_L_a1csu
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01635 LVDCCALPHA1C
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC7TQ58_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C7TQ58
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 5, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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