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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Accumulibacter phosphatis (strain UW-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotationSAAS annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotationSAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processCell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotationSAAS annotation (EC:2.4.1.227UniRule annotationSAAS annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:CAP2UW1_0571Imported
OrganismiAccumulibacter phosphatis (strain UW-1)Imported
Taxonomic identifieri522306 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaCandidatus Accumulibacter
Proteomesi
  • UP000001619 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Protein-protein interaction databases

STRINGi522306.CAP2UW1_0571

Structurei

3D structure databases

ProteinModelPortaliC7RLM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 142Glyco_transf_28InterPro annotationAdd BLAST137
Domaini182 – 344Glyco_tran_28_CInterPro annotationAdd BLAST163

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218321
KOiK02563
OMAiHQTKNAM
OrthoDBiPOG091H02FX

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

C7RLM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKTLLVMAG GTGGHVFPGL AVADLLRSRD WKVVWMGAPD GMEARLVPAR
60 70 80 90 100
GYEMAWVRFA ALRGKGLLRK LLLPFHLFSA CWQARREIRR VSPDVVLGMG
110 120 130 140 150
GYVSFPGGMM AALLGCPLLI HEQNSIAGLA NRVLARVADR VACGFPDVLP
160 170 180 190 200
KGIWVGNPLR PEMTRLPPPT TRLADRQGPV RLLVLGGSQG ASALNDVVPR
210 220 230 240 250
GLALIDADAR PQVVHQAGEK HLEALQHNYA AAGVQAHCAA FIEDMAGAYE
260 270 280 290 300
WADLVICRAG ALTVAELAAT GVASVLVPFP YAVDDHQTAN ARFLSLAGGA
310 320 330 340 350
VLLPQAELTP ETISRLCHTP VGQLRAMAEK AREMARPEAT EEVARMCEEL

AK
Length:352
Mass (Da):37,677
Last modified:October 13, 2009 - v1
Checksum:i27229A37B65EFD54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001715 Genomic DNA Translation: ACV33920.1

Genome annotation databases

EnsemblBacteriaiACV33920; ACV33920; CAP2UW1_0571
KEGGiapp:CAP2UW1_0571

Similar proteinsi

Entry informationi

Entry nameiC7RLM6_ACCPU
AccessioniPrimary (citable) accession number: C7RLM6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 27, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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