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Protein

3-dehydroquinate synthase

Gene

aroB'

Organism
Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.UniRule annotation

Catalytic activityi

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

BioCyciMFER573064:G1GFN-379-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate synthaseUniRule annotation (EC:1.4.1.24UniRule annotation)
Short name:
DHQ synthaseUniRule annotation
Alternative name(s):
3-dehydroquinate synthase IIUniRule annotation
Gene namesi
Name:aroB'UniRule annotation
Ordered Locus Names:Mefer_0373Imported
OrganismiMethanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)Imported
Taxonomic identifieri573064 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000001495 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi573064.Mefer_0373

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili167 – 187Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the archaeal-type DHQ synthase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG04353 Archaea
COG1465 LUCA
HOGENOMiHOG000015603
KOiK11646
OMAiGDRVCID
OrthoDBiPOG093Z0481

Family and domain databases

HAMAPiMF_01244 Arch_DHQ_synthase, 1 hit
InterProiView protein in InterPro
IPR002812 DHQ_synth
PANTHERiPTHR33563 PTHR33563, 1 hit
PfamiView protein in Pfam
PF01959 DHQS, 1 hit
PIRSFiPIRSF006655 DHQ_synth, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD017907 DHQ_synth_pro-type, 1 hit

Sequencei

Sequence statusi: Complete.

C7P6M5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFGWVNVVG DDWEDKKEIV TMALESSIPV VVAQPDDIEK IKELGNIKVA
60 70 80 90 100
SHSLDADIVL INKDDDIEFL KEAKNMGKET AIYIPIESKD DEEFASEVAR
110 120 130 140 150
FGFVDNIILE GRDWTIIPLE NLIADLFHRD VKIIASVDSV DEVKVAYEIL
160 170 180 190 200
EKGTDGVLLT PKNLEDIKEL SKLIEEMNKE KVALDVATIT RVEPIGSGDR
210 220 230 240 250
VCIDTCSLMN IGEGMLIGSY SRALFLVHSE TVENPYVATR PFRVNAGPVH
260 270 280 290 300
AYILCPGNKT KYLSELKAGD KVLIVDKDGN AREAIVGRVK IERRPLILIE
310 320 330 340 350
AEYKGDIVRT ILQNAETIRL VNENGEPVSV VDLKPGDKVL IKPEEHARHF
360
GMAIKETIIE K
Length:361
Mass (Da):40,242
Last modified:October 13, 2009 - v1
Checksum:i6627BCDF710B2E22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA Translation: ACV24207.1
RefSeqiWP_015790947.1, NC_013156.1

Genome annotation databases

EnsemblBacteriaiACV24207; ACV24207; Mefer_0373
GeneIDi8365042
KEGGimfe:Mefer_0373

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA Translation: ACV24207.1
RefSeqiWP_015790947.1, NC_013156.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573064.Mefer_0373

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV24207; ACV24207; Mefer_0373
GeneIDi8365042
KEGGimfe:Mefer_0373

Phylogenomic databases

eggNOGiarCOG04353 Archaea
COG1465 LUCA
HOGENOMiHOG000015603
KOiK11646
OMAiGDRVCID
OrthoDBiPOG093Z0481

Enzyme and pathway databases

BioCyciMFER573064:G1GFN-379-MONOMER

Family and domain databases

HAMAPiMF_01244 Arch_DHQ_synthase, 1 hit
InterProiView protein in InterPro
IPR002812 DHQ_synth
PANTHERiPTHR33563 PTHR33563, 1 hit
PfamiView protein in Pfam
PF01959 DHQS, 1 hit
PIRSFiPIRSF006655 DHQ_synth, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD017907 DHQ_synth_pro-type, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC7P6M5_METFA
AccessioniPrimary (citable) accession number: C7P6M5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 7, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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